| Project/Area Number |
25670805
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
NEMOTO EIJI 東北大学, 歯学研究科(研究院), 准教授 (40292221)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHATA HIROSHI 東北大学, 大学院歯学研究科, 助教 (40261523)
TSUCHIYA MASAHIRO 東北大学, 大学院歯学研究科, 大学院非常勤講師 (60372322)
KANAYA SOUSUKE 東北大学, 大学院歯学研究科, 助教 (80375097)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 歯内療法 / 低出力超音波パルス / 歯髄細胞 / オステオポンチン / 象牙質 |
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| Outline of Final Research Achievements |
It is one of the big aims of dentistry to regenerate a tooth substance (dentin), which is lost by dental caries. We demonstrated that LIPUS exposure to dental pulp cells induces the expression of BMP-2, which is known to be a powerful osteogenic growth factor. Moreover, the expression of osteopontin, an osteogenic differentiation marker, was enhanced by LIPUS, where extracellular ATP released from cell acts on purinergic receptors on dental pulp cells. These findings suggest that LIPUS exposure can be an effective and non-invasive endodontic therapy for dentin regeneration.
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