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Impairment of masticatory ability would induce the metabolic syndrome.

Research Project

Project/Area Number 25670813
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionTohoku University

Principal Investigator

TSUCHIYA Masahiro  東北大学, 歯学研究科(研究院), 大学院非常勤講師 (60372322)

Co-Investigator(Kenkyū-buntansha) SASAKI Keiichi  東北大学, 大学院歯学研究科, 教授 (30178644)
KUROISHI Toshinobu  東北大学, 大学院歯学研究科, 助教 (30400261)
NISHIOKA Takashi  東北大学, 大学院歯学研究科, 助教 (50641875)
Co-Investigator(Renkei-kenkyūsha) ENDO Yasuo  東北大学, 大学院歯学研究科, 教育支援者 (50005039)
YAOITA Fukie  東北薬科大学, 薬学部, 助教 (00382672)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords咀嚼 / メタボリックシンドローム / グライセミックインデックス / 咀嚼障害 / 食育 / 糖尿病 / Soft food / 咀嚼機能
Outline of Final Research Achievements

The hyperglycemia associated with long-term powdered-food feeding may lead to certain systemic illness signs, such as elevations of blood glucose and hypertension in mice. Mastication is very important for the maintenance of systemic health, via reduction in the levels of blood glucose and/or stress hormones .
Chewing dysfunction was reported as a risk factor for metabolic syndrome. Our results suggest that the dietary habits of patients are as important as the nutritional dietary information that they receive. Diet therapy is critically important in the management of diabetes. Meanwhile, chewing ability is often neglected in the care of diabetic patients. Considering that people who are losing their teeth tends to prefer a soft diet, patients with chewing dysfunctions such as edentulous patients could not properly undergo diet therapy. With decreased chewing function, dental care, including implants, should be an effective choice compared with simple medication management.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (10 results)

  • [Journal Article] Chondrogenic and fibrotic process in the ligamentum flavum of patients with lumbar spinal canal stenosis.2015

    • Author(s)
      Yabe Y, Hagiwara Y, Ando A, Tsuchiya M, Minowa T, Takemura T, Honda M, Hatori K, Sonofuchi K, Kanazawa K, Koide M, Sekiguchi T, Itoi E.
    • Journal Title

      Spine

      Volume: 40 Issue: 7 Pages: 429-435

    • DOI

      10.1097/brs.0000000000000795

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous evaluation of articular cartilage and subchondral bone from immobilized knee in rats by photoacoustic imaging system.2015

    • Author(s)
      Hagiwara Y, Izumi T, Yabe Y, Sato M, Sonofuchi K, Kanazawa K, Koide M, Saijo Y, Itoi E.
    • Journal Title

      J Orthop Sci.

      Volume: 20 Issue: 2 Pages: 397-402

    • DOI

      10.1007/s00776-014-0692-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deterioration of polymethyl methacrylate dentures in the oral cavity2015

    • Author(s)
      Matsuo H, Suenaga H, Takahashi M, Suzuki O, Sasaki K, Takahashi N.
    • Journal Title

      Dental Materials Journal

      Volume: 34 Issue: 2 Pages: 234-239

    • DOI

      10.4012/dmj.2014-089

    • NAID

      130005062412

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term feeding on powdered food causes hyperglycemia and signs of systemic illness in mice.2014

    • Author(s)
      Tsuchiya M, Niijima-Yaoita F, Yoneda H, Chiba K, Tsuchiya S, Hagiwara Y, Sasaki K, Sugawara S, Endo Y, Tan-No K, Watanabe M.
    • Journal Title

      Life Sci.

      Volume: 103 Issue: 1 Pages: 8-14

    • DOI

      10.1016/j.lfs.2014.03.022

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Resin monomers act as adjuvants in Ni-induced allergic dermatitis in vivo.2014

    • Author(s)
      Bando K, Takahashi H, Kinbara M, Tanaka Y, Kuroishi T, Sasaki K, Takano-Yamamoto T, Sugawara S, Endo Y.
    • Journal Title

      journal of dental research

      Volume: 93 Issue: 11 Pages: 1101-1107

    • DOI

      10.1177/0022034514552674

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Roles played by histamine in strenuous or prolonged masseter muscle activity in mice.2013

    • Author(s)
      Yoneda H, Niijima-Yaoita F, Tsuchiya M, Kumamoto H, Watanabe M, Ohtsu H, Yanai K, Tadano T, Sasaki K, Sugawara S, Endo Y.
    • Journal Title

      Clin Exp Pharmacol Physiol.

      Volume: 40 Issue: 12 Pages: 848-855

    • DOI

      10.1111/1440-1681.12167

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extracellular ATP inhibits IL-1-induced MMP-1 expression through the action of CD39/nucleotidase triphosphate dephosphorylase-1 on human gingival fibroblasts.2013

    • Author(s)
      Nemoto E, Gotoh K, Tsuchiya M, Sakisaka Y, Shimauchi H.
    • Journal Title

      Int Immunopharmacol.

      Volume: 17 Issue: 3 Pages: 513-518

    • DOI

      10.1016/j.intimp.2013.07.014

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of a long-term powdered diet on the social interaction test and dopaminergic systems in mice.2013

    • Author(s)
      Niijima-Yaoita F, Tsuchiya M, Saito H, Nagasawa Y, Murai S, Arai Y, Nakagawasai O, Nemoto W, Tadano T, Tan-No K.
    • Journal Title

      Neurochem Int.

      Volume: 63 Issue: 4 Pages: 309-315

    • DOI

      10.1016/j.neuint.2013.07.004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Physiological distal drift in rat molars contributes to acellular cementum formation.2013

    • Author(s)
      Tsuchiya S, Tsuchiya M, Nishioka T, Suzuki O, Sasano Y, Igarashi K.
    • Journal Title

      Anat Rec.

      Volume: 296 Issue: 8 Pages: 1255-1263

    • DOI

      10.1002/ar.22731

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 第一世代抗ヒスタミン薬の鎮痛効果2014

    • Author(s)
      高橋萌、島和弘、土谷昌広、渡邉誠、菅原俊二、遠藤康男
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] N-BPsはalkyl 型・heterocyclic 型を問わずリン酸トランスポーター SLC20/34 を介して細胞内に取り込まれ炎症壊死を起こす2014

    • Author(s)
      佐藤衣莉,、土谷昌広、木山朋美、大泉丈史、山口晃史、菅原俊二、遠藤康男
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 窒素含有 bisphosphonates(N-BPs)治療患者での顎骨壊死:N-BPs の etidronate(non-N-BP)への置換の試み2014

    • Author(s)
      大泉丈史,、山口晃史、鈴木飛佳理、土谷昌広、菅原俊二、高橋哲、遠藤康男
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 粉末食長期飼育はマウス糖代謝機構を障害し社会性行動の変化をもたらす2014

    • Author(s)
      千葉航、土谷昌広、渡邉誠、菅原俊二、遠藤康男
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 長期飼育における粉末食のマウス糖代謝機構への影響と行動異常の誘発に関する研究2014

    • Author(s)
      千葉 航,土谷昌広,渡邉 誠,佐々木啓一,坪井明人,服部佳功
    • Organizer
      日本補綴歯科学会第123回学術大会
    • Place of Presentation
      仙台
    • Year and Date
      2014-05-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Roles played by IL-1 in prolonged masseter muscle activity in mice2014

    • Author(s)
      Chiba K, Tsuchiya M, Sasaki K, Tsuboi A, Hattori Y, Sugawara S, Endo Y
    • Organizer
      The 5th international symposium for interface oral health symposium
    • Place of Presentation
      Sendai
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス咬筋長時間活動におけるヒスタミンの役割2013

    • Author(s)
      米田博行,土谷昌広,八百板(新島)富紀枝,佐々木啓一,渡邉 誠,菅原俊二, 遠藤康男
    • Organizer
      日本顎口腔機能学会 第50回記念学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 粉末食飼育はマウスの糖代謝機構を障害し,行動異常を誘発する2013

    • Author(s)
      千葉航,土谷昌広,八百板(新島)富紀枝,米田博行,渡邉誠,佐々木啓一
    • Organizer
      日本老年歯科医学会 第24回 学術大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 粉末食飼育マウスにおけるSocial interactionの障害について

    • Author(s)
      八百板富紀枝,荒井香,下道麻夏,齊藤貴之,土谷昌広,斉藤弘子,村井繁夫,荒井裕一朗,根本亙,中川西修,只野武,丹野孝一
    • Organizer
      平成25年度東北薬科大学創薬研究センターシンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 骨粗鬆症・変形性関節症でのジフェンヒドラミン軟膏の鎮痛作用:skin impedance による評価

    • Author(s)
      藤田拓男,大植睦,藤井芳夫,常徳剛,宮内章光,高木康行,土谷昌広,遠藤康男
    • Organizer
      第17回日本ヒスタミン学会
    • Place of Presentation
      松江
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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