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The molecular basis of the relationship between Alzheimer's disease and tooth loss

Research Project

Project/Area Number 25670820
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionOhu University

Principal Investigator

AKAGAWA YASUMASA  奥羽大学, 歯学部, 教授 (00127599)

Co-Investigator(Kenkyū-buntansha) MICHIKAWA Makoto  名古屋市立大学, 大学院医学研究科, 教授 (40270912)
KORETAKE Katsunori  広島大学, 大学院医歯薬保健学研究院, 助教 (50346508)
宮本 泰成  広島大学, その他の研究科, 助教 (00555146)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsアルツハイマー病 / 歯の喪失 / 咬合
Outline of Final Research Achievements

We tested the effect of tooth loss on learning and memory and on the molecular pathogenesis of Alzheimer's disease (AD) in an aged AD model mice.
We divided 14-month-old AD model mice into upper molar extracted group (experimental) and molar intact group (control). At 18 months old, we analysed the changes of amyloid-beta (Aβ), pyramidal cells in the brain and the learning and memory ability.
The amount of Aβ and the number of pyramidal cells in the hippocampus were not significantly different between the experimental and control group. Similarly, the difference of learning and memory ability could not be distinguished between the groups. Neither molecular pathogenesis of AD nor associated learning and memory were aggravated by tooth loss in these mice. The limited results of this study which used the aged mice may help the dental profession to plan and explain treatments to patients with AD, which must be designed while taking into account the severity of the AD symptoms.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Tooth loss might not alter molecular pathogenesis in an aged transgenic Alzheimer's disease model mouse2015

    • Author(s)
      Oue H, Miyamoto Y, Koretake K, Okada S, Doi K, Jung CG, Michikawa M and Akagawa Y
    • Journal Title

      Gerodontology

      Volume: in press Issue: 3 Pages: 308-14

    • DOI

      10.1111/ger.12153

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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