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Development of treatment for occlusal dysethesia with botulinum toxin

Research Project

Project/Area Number 25670821
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionThe University of Tokushima

Principal Investigator

MATSUKA Yoshizo  徳島大学, 大学院医歯薬学研究部, 教授 (90243477)

Co-Investigator(Kenkyū-buntansha) KAJI Ryuji  徳島大学, 大学院医歯薬学研究部, 教授 (00214304)
SHIGEMOTO Shuji  徳島大学, 大学院医歯薬学研究部, 助教 (20294704)
SUZUKI Yoshitaka  徳島大学, 大学院医歯薬学研究部, 助教 (40581393)
OKURA Kazuo  徳島大学, 大学院医歯薬学研究部, 講師 (70304540)
TAKEUCHI Hisahiro  徳島大学, 病院, 講師 (10222093)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords咬合感覚異常 / ボツリヌス毒素 / ブラキシズム / 口腔顔面痛 / 咬合異常感覚
Outline of Final Research Achievements

Occlusal dysethesia patient (1. complain occlusal contact abnormality at central occlusion more than 6 months, 2. patient can point the problem tooth) who agreed the boltulinum toxin treatment was injected botulinum toxin after masseter muscle activity recording. The occlusal abnormal sensation was measured with Visual Analogue Scale(VAS). After boltulinum toxin injection, orofacial pain was decreased but occlusal dysethesia sensation was not decreased significantly.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (24 results)

All 2016 2015 2014 2013 2011

All Journal Article (13 results) (of which Peer Reviewed: 12 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (11 results)

  • [Journal Article] Japan Prosthodontic Society position paper on ‘‘occlusal discomfort syndrome''2016

    • Author(s)
      Tamaki K, Ishigaki S, Ogawa T, Oguchi H, Kato T, Suganuma T, Shimada A, Sadamori S, Tsukiyama Y, Nishikawa Y, Masumi S, Yamaguchi T, Aita H, Ono T, Kondo H, Tsukasaki H, Fueki K, Fujisawa M, Matsuka Y, Baba K, Koyano K
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 60 Issue: 3 Pages: 156-166

    • DOI

      10.1016/j.jpor.2015.11.002

    • NAID

      130005172104

    • ISSN
      1883-1958, 1883-9207
    • Year and Date
      2016-07-25
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A preliminary investigation of reproducibility of EMG signals during daytime masticatory muscle activity using a portable EMG logging device2015

    • Author(s)
      Omoto K, Shigemoto S, Suzuki Y, Nakamura M, Okura K, Nishigawa K, Goto N, Rodis OM, Matsuka Y
    • Journal Title

      J Electromyogr Kinesiol.

      Volume: 25 Issue: 4 Pages: 603-11

    • DOI

      10.1016/j.jelekin.2015.04.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of an exclusion range of jaw movement data from theintercuspal positionon the estimation of the kinematic axis point2014

    • Author(s)
      Shuji Shigemoto, Nobuyuki Bando, Keisuke Nishigawa, Yoshitaka Suzuki, Toyoko Tajima, Kazuo Okura, Yoshizo Matsuka
    • Journal Title

      Medical Engineering & Physics

      Volume: 36 Issue: 9 Pages: 1162-1167

    • DOI

      10.1016/j.medengphy.2014.06.013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case report of recurrent temporomandibular joint open lock associated with abrupt reduction of displaced articular disk2014

    • Author(s)
      Nishigawa K, Nakano M, Ishikawa T, Bando E, Matsuka Y
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 58 Issue: 3 Pages: 184-190

    • DOI

      10.1016/j.jpor.2014.04.001

    • NAID

      130004953503

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systematic review and recommendations for nonodontogenic toothache2014

    • Author(s)
      Yatani H, Komiyama O, Matsuka Y, Wajima K, Muraoka W, Ikawa M, Sakamoto E, De Laat A , Heir GM
    • Journal Title

      J Oral Rehabil

      Volume: 41 Issue: 11 Pages: 843-852

    • DOI

      10.1111/joor.12208

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of platelet serotonin transporter activity in subjects with severe sleep bruxism and control2014

    • Author(s)
      Hajime Minakuchi, Chiharu Sogawa C, Emilio Satoshi Hara, Haruna Miki, Kenji Maekawa, Norio Sogawa, Shigeo Kitayama, Yoshizo Matsuka, Glenn T Clark, Takuo Kuboki
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 58 Issue: 4 Pages: 217-222

    • DOI

      10.1016/j.jpor.2014.06.003

    • NAID

      130004714111

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 歯の6自由度運動を視覚的に理解する手法の開発2014

    • Author(s)
      田島登誉子,重本修伺,鈴木善貴,大倉一夫,ロディス オマー,松香芳三
    • Journal Title

      日本口腔リハビリテーション学会雑誌

      Volume: 27 Pages: 17-23

    • NAID

      40020380074

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A multi-institution investigation of the status of patients who complain of occlusal discomfort2014

    • Author(s)
      澁谷智明,和気裕之, 玉置勝司, 島田淳,古谷野潔,鱒見進一, 窪木拓男,皆木省吾,貞森紳丞, 矢谷博文,藤澤政紀,林 勝彦, 玉井和樹,成田紀之,原 節宏, 馬場一美,尾口仁志,金村清孝, 山口泰彦,西川洋二,塚原宏泰, 松香芳三,葉山莉香
    • Journal Title

      Journal of the Japanese Society for the Temporomandibular Joint

      Volume: 26 Issue: 3 Pages: 196-203

    • DOI

      10.11246/gakukansetsu.26.196

    • NAID

      130004843350

    • ISSN
      0915-3004, 1884-4308
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 摂食・咀嚼・嚥下過程における各種生体情報の記録解析法の開発―測定システムの開発―2014

    • Author(s)
      重本修伺,田島登誉子,鈴木善貴,大倉一夫, 井川知子, 小川 匠, 松香芳三
    • Journal Title

      日本口腔リハビリテーション学会雑誌

      Volume: 27 Pages: 29-37

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Self-reported aural symptoms, headache and temporomandibular disorders in Japanese young adults2013

    • Author(s)
      Akhter R et al
    • Journal Title

      BMC Musculoskelet Disord

      Volume: 14 Issue: 1 Pages: 58-64

    • DOI

      10.1186/1471-2474-14-58

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 非歯原性歯痛の発症機序,診断,治療2013

    • Author(s)
      松香芳三
    • Journal Title

      四国歯学会雑誌

      Volume: 25 Pages: 29-38

    • NAID

      120005832453

    • Related Report
      2013 Research-status Report
  • [Journal Article] Roles of dental pulp fibroblasts in the recognition of bacterium-related factors and subsequent development of pulpitis2011

    • Author(s)
      Nakanishi T, Takegawa D, Hirao K, Takahashi K, Yumoto H, Matsuo T
    • Journal Title

      Jap Dent Sci Rev

      Volume: 47 Issue: 2 Pages: 161-166

    • DOI

      10.1016/j.jdsr.2011.02.001

    • NAID

      10029548123

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bleaching Effect of Blue-Violet-Diode-Laser Irradiation to Tooth Enamel with TiO2 Application2011

    • Author(s)
      玉置勝司,石垣尚一,小川 匠,尾口仁志,加藤隆史,菅沼岳史, 島田 淳,貞森紳丞,築山能大, 西川洋二,鱒見進一,山口泰彦, 會田英紀,小野高裕,近藤尚知, 塚崎弘明,笛木賢治,藤澤政紀, 松香芳三,馬場一美,古谷野 潔
    • Journal Title

      Annals of Japan Prosthodontic Society

      Volume: 3 Issue: 1 Pages: 26-31

    • DOI

      10.2186/ajps.3.26

    • NAID

      130004544530

    • ISSN
      1883-4426, 1883-6860
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 骨伝道センサを用いた歯列接触検出装置の開発2015

    • Author(s)
      西川啓介,大本勝弘,重本修伺,葉山莉香,細木真紀,松香芳三
    • Organizer
      日本顎関節学会・日本口腔顔面痛学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 顎機能異常者における運動論的基準軸の検討2015

    • Author(s)
      平井真也,井川知子,平林里大, 安藤栄里子,重田優子,重本修伺, 小川 匠,松香芳三
    • Organizer
      日本顎関節学会・日本口腔顔面痛学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 末梢知覚神経節における神経伝達物質遊離抑制と鎮痛効果2014

    • Author(s)
      田中紗友里,大本勝弘,丸濱功太郎,杉本朋貞,松香芳三
    • Organizer
      日本補綴歯科学会中国・四国、関西支部合同学術大会
    • Place of Presentation
      倉敷市芸文館(岡山県・倉敷市)
    • Year and Date
      2014-09-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 簡易貼付型睡眠時ブラキシズム測定装置の測定制度の検討2014

    • Author(s)
      三木春奈, 水口 一, 上枝麻友, 重本修伺, 鈴木善貴, 前川賢治, 松香芳三, 窪木拓男
    • Organizer
      日本顎関節学会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県・福岡市)
    • Year and Date
      2014-07-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 連続24時間咬筋筋電図記録によるTCH検査法の検討2014

    • Author(s)
      大本勝弘, 重本修伺, 松香芳三
    • Organizer
      日本顎関節学会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県・福岡市)
    • Year and Date
      2014-07-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 連続 24 時間筋電図記録による覚醒時と睡眠時の咬筋活動の比較2014

    • Author(s)
      大本勝弘,重本修伺,後藤奈美,鈴木善貴,上枝麻友,髙橋陽光,松香芳三
    • Organizer
      日本補綴歯科学会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 携帯型筋電計を用いた終日咬筋活動測定2014

    • Author(s)
      大本勝弘, 重本修伺,鈴木善貴,田島登誉子, 松香芳三
    • Organizer
      日本顎口腔機能学会
    • Place of Presentation
      岡山大学(岡山県・岡山市)
    • Year and Date
      2014-04-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 携帯型筋電計測定による覚醒時と睡眠時の筋活動比較2014

    • Author(s)
      岩田こころ, 黒厚子璃佳, 大本勝弘,鈴木善貴,高田奈美, 重本修伺, 松香芳三
    • Organizer
      四国歯学会
    • Place of Presentation
      徳島大学(徳島県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Botulinum toxin endocytosed trigeminal neurons alleviates neuropathic pain2013

    • Author(s)
      Omoto K, Suzuki Y, Maruhama K, Yamamoto Y, Terayama R, Spigelman I, Kamioka H, Maekawa K, Sugimoto T, Matsushita O, Kuboki T, Matsuka Y
    • Organizer
      Asia Academic Congress for Temporomandibular Joint
    • Place of Presentation
      International Communication Branch (China)
    • Related Report
      2013 Research-status Report
  • [Presentation] The pattern of jaw movements in rhythmic masticatory muscle activity2013

    • Author(s)
      Suzuki Y, Okura K, Shigemoto S, Abe S, Matsuka Y
    • Organizer
      International Association for Dental Research Asia Pacific Region
    • Place of Presentation
      Plaza Athenee (Tahiland)
    • Related Report
      2013 Research-status Report
  • [Presentation] 日中の咬筋活動様式2013

    • Author(s)
      大本勝弘,重本修伺,高田奈美, 鈴木善貴,大倉一夫,細木真紀,田島登誉子,神原佐知子,松香芳三
    • Organizer
      日本補綴歯科学会 中国・四国支部学術大会
    • Place of Presentation
      高知あんしんセンター(高知県)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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