Mechanisms of osseointegration induced by enhanced osteocyte network via mechanical repetitive loading
| Project/Area Number |
25670824
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Nagasaki University |
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Principal Investigator |
SAWASE Takashi 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (80253681)
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| Co-Investigator(Kenkyū-buntansha) |
KUROSHIMA Shinichiro 長崎大学, 病院(歯学系), 講師 (40443915)
WATAMOTO Takao 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (60420444)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | デンタルインプラント / 骨細胞 / 荷重 / オステオネットワーク / 生体力学 / 細胞死 / オートファジー / 培養細胞 / 歯科補綴学 / インプラント / オッセオインテグレーション / 骨芽細胞 / 破骨細胞 |
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| Outline of Final Research Achievements |
Implant therapy is one of available options for replacing missing teeth. The clarification of load effect on bone around dental implants plays an important role in Long-term success for implant treatment. However, studies to address the load effect on bone around implants have not been developed. The aim of this study was to investigate the influence of mechanical repetitive loading on osteocyte network around dental implants in vivo and in vitro.
Mechanical repetitive loading developed osteocyte networks and suppressed osteocyte apoptosis, affecting bone formation and bone microstructure around implants.
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Report
(3 results)
Research Products
(27 results)
