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Mechanisms of osseointegration induced by enhanced osteocyte network via mechanical repetitive loading

Research Project

Project/Area Number 25670824
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionNagasaki University

Principal Investigator

SAWASE Takashi  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (80253681)

Co-Investigator(Kenkyū-buntansha) KUROSHIMA Shinichiro  長崎大学, 病院(歯学系), 講師 (40443915)
WATAMOTO Takao  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (60420444)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsデンタルインプラント / 骨細胞 / 荷重 / オステオネットワーク / 生体力学 / 細胞死 / オートファジー / 培養細胞 / 歯科補綴学 / インプラント / オッセオインテグレーション / 骨芽細胞 / 破骨細胞
Outline of Final Research Achievements

Implant therapy is one of available options for replacing missing teeth. The clarification of load effect on bone around dental implants plays an important role in Long-term success for implant treatment. However, studies to address the load effect on bone around implants have not been developed. The aim of this study was to investigate the influence of mechanical repetitive loading on osteocyte network around dental implants in vivo and in vitro.
Mechanical repetitive loading developed osteocyte networks and suppressed osteocyte apoptosis, affecting bone formation and bone microstructure around implants.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (27 results)

All 2015 2014 2013

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Invited: 1 results)

  • [Journal Article] Structural and Qualitative Bone Remodeling around Repetitive Loaded Implants in Rabbits2015

    • Author(s)
      S. Kuroshima, M. Yasutake, K. Tsuiki, T. Nakano, T. Sawase
    • Journal Title

      Clinical Implant Dentistry and Related Research

      Volume: in press Issue: S2

    • DOI

      10.1111/cid.12318

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 骨質評価が変えるオッセオインテグレーションの新展開2015

    • Author(s)
      黒嶋伸一郎
    • Journal Title

      日本口腔インプラント学会誌

      Volume: 28 Pages: 4-10

    • NAID

      130005065626

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical evaluation of chlorine dioxide for disinfection of dental instruments.2014

    • Author(s)
      Watamoto T, Egusa H, Sawase T, Yatani H.
    • Journal Title

      Int J Prosthodont.

      Volume: 26 Issue: 6 Pages: 541-544

    • DOI

      10.11607/ijp.3465

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of polishing and finishing procedures on the surface integrity on restorative ceramics2013

    • Author(s)
      Odatsu T, Jimbo R, Wennerberg A, Watanabe I, Sawase T
    • Journal Title

      Am J Dent

      Volume: 26 Pages: 51-55

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative study between laser sintering and casting for retention of resin composite veneers to cobalt-chromium alloy2013

    • Author(s)
      Muratomi R, Kamada K, Taira Y, Higuchi S, Watanabe I, Sawase T
    • Journal Title

      Dent Mater J

      Volume: 32 Pages: 939-945

    • NAID

      10031203551

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of sandblasting, H2SO4/HCl etching, and phosphate primer application on bond strength of veneering resin composite to commercially pure titanium grade 42013

    • Author(s)
      Egoshi T, Taira Y, Soeno K, Sawase T
    • Journal Title

      Dent Mater J

      Volume: 32 Pages: 219-227

    • NAID

      10031151404

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Factors affecting bond strength of denture base and reline acrylic resins to base metal materials2013

    • Author(s)
      N. Tanoue, Y. Matsuda, H. Yanagida, H. Matsumura, T. Sawase
    • Journal Title

      Journal of Applied Oral Science

      Volume: 21 Issue: 4 Pages: 320-326

    • DOI

      10.1590/1678-775720130134

    • NAID

      120006986077

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of four silane primers and an isocyanate primer for bonding of tri-<i>n</i>-butylborane resin to a leucite-reinforced glass ceramic2013

    • Author(s)
      Taira Y, Sakai M, Soeno K, Sawase T
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 57 Issue: 2 Pages: 88-92

    • DOI

      10.1016/j.jpor.2012.09.002

    • NAID

      130004546665

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of a fluoride etchant and a phosphate primer on bonding of veneering composite to Ti&ndash;6Al&ndash;4V alloy for CAD/CAM restorations2013

    • Author(s)
      Taira Y, Odatsu T, Sawase T
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 57 Issue: 1 Pages: 30-35

    • DOI

      10.1016/j.jpor.2012.08.002

    • NAID

      130004679555

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemotherapeutic and antiresorptive combination therapy suppressed lymphangiogenesis and induced osteonecrosis of the jaw-like lesions in mice2013

    • Author(s)
      Kuroshima S, Yamashita J
    • Journal Title

      Bone

      Volume: 56 Issue: 1 Pages: 101-109

    • DOI

      10.1016/j.bone.2013.05.013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intra-oral PTH administration promotes tooth extraction socket healing2013

    • Author(s)
      Kuroshima S, Kozloff KM, McCauley LK, Yamashita J.
    • Journal Title

      Journal of Dental Research

      Volume: 92 Issue: 6 Pages: 553-559

    • DOI

      10.1177/0022034513487558

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of zoledronate on the responses of osteocytes to acute parathyroid hormone2013

    • Author(s)
      Kuroshima S, Elliot EK, Yamashita J
    • Journal Title

      Calcif Tissue Int

      Volume: 92 Issue: 6 Pages: 576-585

    • DOI

      10.1007/s00223-013-9720-z

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Parathyroid hormone related to bone regeneration in grafted and non-grafted tooth extraction sockets in rats2013

    • Author(s)
      Kuroshima S, Salihi ZA, Yamashita J
    • Journal Title

      Implant Dent

      Volume: 22 Issue: 1 Pages: 71-76

    • DOI

      10.1097/id.0b013e318278f94d

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Altered Osteocyte Communications under Mechanical Loading via Integrated Dental Implants in Rabbits.2015

    • Author(s)
      Kuroshima S, Sasaki M, Sawase T
    • Organizer
      93rd General Session & Exhibition of the IADR
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] メカニカルストレスに対するインプラント周囲骨細胞の反応2014

    • Author(s)
      佐々木宗輝,黒嶋伸一郎,澤瀬 隆
    • Organizer
      第22回顎顔面バイオメカニクス学会学術大会
    • Place of Presentation
      Nagasaki, Japan
    • Year and Date
      2014-11-22 – 2014-11-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨質評価が変えるオッセオインテグレーションの新展開 New perspectives in osseointegration by evaluating bone quality around dental implants2014

    • Author(s)
      黒嶋伸一郎
    • Organizer
      第44回公益社団法人日本口腔インプラント学会
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2014-09-12 – 2014-09-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Mecahnical repetitive loading enhances bone quality around dental implatns in rabbits.2014

    • Author(s)
      Kuroshima S, Nakano T, Yasutake M, Sasaki M, Sawase T.
    • Organizer
      The 9th congress of the Asian Academy of Osseointegration
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2014-07-04 – 2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] An in vivo new assessment of load distribution around dental implant2013

    • Author(s)
      Sawase T, Nakano T
    • Organizer
      Biennial Joint Congress of CPS-JPS-KAP
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Evaluation of dual-functional treatments applied for bonding reline materials to base metals2013

    • Author(s)
      Matsuda Y, Tanoue N, Sawase T
    • Organizer
      The 5th international Congress of Dental Technology
    • Place of Presentation
      Daejeon, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Repetitive loading enhances bone quality and quality around implant in rabbits2013

    • Author(s)
      Kuroshima S, Yasutake M, Ishimoto T, Nakano T, Sawase T
    • Organizer
      European Association for Osseointegration
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2013 Research-status Report
  • [Presentation] Parathyroid Hormone Rescues Impaired Tooth Extraction Healing Associated with Bisphosphonates2013

    • Author(s)
      Yamashita J, Mccauley L.K, Kuroshima S
    • Organizer
      ASBMR 2013 Annual Meeting
    • Place of Presentation
      Baltimore, MD, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] リンパ管形成と顎骨壊死2013

    • Author(s)
      黒嶋伸一郎,山下潤朗
    • Organizer
      公益社団法人日本歯科補綴学会 設立80周年記念 第122回学術大会
    • Place of Presentation
      福岡、国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 規則的荷重負荷で達成されるオッセオインテグレーションと骨微細構造の適応変化2013

    • Author(s)
      黒嶋伸一郎,安武宗徳,宮原健治,中野貴由,澤瀬 隆
    • Organizer
      公益社団法人日本歯科補綴学会 設立80周年記念 第122回学術大会
    • Place of Presentation
      福岡、国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] インプラントデザインの相違がインプラント周囲の骨形成に与える影響2013

    • Author(s)
      安武宗徳,黒嶋伸一郎,宮原健治,小野大輔,澤瀬 隆
    • Organizer
      公益社団法人日本補綴歯科学会九州支部学術大会
    • Place of Presentation
      佐賀、アバンセ
    • Related Report
      2013 Research-status Report
  • [Presentation] インプラントの繰り返し荷重がもたらすオッセオインテグレーションの亢進と周囲骨組織の骨質向上2013

    • Author(s)
      黒嶋伸一郎,安武宗徳,宮原健治,中野貴由,澤瀬 隆
    • Organizer
      公益社団法人日本口腔インプラント学会第43回学術大会
    • Place of Presentation
      福岡、国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] チタン合金へのマイクログルーブ付与は骨組織の形成を促進する2013

    • Author(s)
      綿本隆生,宮原健治,澤瀬 隆
    • Organizer
      第43回公益社団法人日本口腔インプラント学会学術大会
    • Place of Presentation
      福岡、国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 繰り返し荷重によるインプラント周囲骨組織の骨質向上2013

    • Author(s)
      黒嶋伸一郎,安武宗徳,宮原健治,中野貴由,澤瀬 隆
    • Organizer
      第21回顎顔面バイオメカニクス学会学術大会
    • Place of Presentation
      東京、東京工業大学
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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