| Project/Area Number |
25670833
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
ATSUTA Ikiru 九州大学, 歯学研究科(研究院), 教授 (50195872)
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| Co-Investigator(Kenkyū-buntansha) |
ATSUTA Ikiru 九州大学, 大学院歯学研究院口腔機能修復学講座インプラント・義歯補綴科 (30423487)
AYUKAWA Yasunori 九州大学, 大学院歯学研究院口腔機能修復学講座インプラント・義歯補綴科 (50304697)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 間葉系幹細胞 / 歯科インプラント治療 / 歯科インプラント / ニッチ / Niche / 創傷治癒 / インプラント周囲上皮 |
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| Outline of Final Research Achievements |
Dental implant therapy is one of the most important prosthodontic therapy options for partially and completely edentulous patients. Dental implants based on the concept of “osseointegration”, a term explaining the fixation of a titanium implant in the bone (Branemark et al., 1983), have shown dramatic continual improvement. However, the peri-implant tissue is always exposed to the possibility of inflammation because the titanium body penetrates into the oral mucosa.Therefore, the improvement of local defense in mucosa is strongly expected to enable successful outcomes in oral implant patients. In this study, we showed that systemic MSC transplantation may be effective for enhancing epithelial sealing around titanium implants.
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