| Project/Area Number |
25670836
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
DEZAWA Mari 東北大学, 大学院医学系研究科, 教授 (50272323)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Muse細胞 / 臍帯 / 臍帯由来間葉系細胞 / 歯周組織再生 / 再生医学・医療 / 歯学 / 再生医工学 / ゼラチンハイドロゲル / MUSE細胞 |
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| Outline of Final Research Achievements |
It has been reported that human stem tissues contain Muse cells, which have multilineage potential but do not have neoplasm generating characteristics. The purpose of this study is the development of tissue-engineering, periodontal regenerative therapy by using Muse cells in umbilical cord tissue, which is medical waste, and a gelatine hydrogel.
As a result of sorting the cells, which were obtained from an umbilical cord by a method that we have reported on in the past, using SSEA-3, CD105 according to cytohistology protocols at the Graduate School of Medicine, Tohoku University, it was observed that the umbilical cord tissue had Muse cells with multilineage potential. In addition, the effectiveness of a gelatine hydrogel was confirmed as a result of human clinical studies. This study was performed under the authorization of the ethical review committee of the Faculty of Dentistry, Tsurumi University (receipt number: No.1203).
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