| Project/Area Number |
25670845
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Chiba University |
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Principal Investigator |
UZAWA KATSUHIRO 千葉大学, 医学(系)研究科(研究院), 准教授 (30302558)
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| Co-Investigator(Kenkyū-buntansha) |
TANZAWA Hideki 千葉大学, 大学院医学研究院, 教授 (50236775)
KASAMATSU Atsushi 千葉大学, 医学部付属病院, 助教 (60375730)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 唾液腺萎縮 / direct reprogramming / 唾液腺再生 |
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| Outline of Final Research Achievements |
Various studies aimed for functional recovery of salivary glands have been performed, but is not able to establish the specific treatment. For salivary gland functional recovery, we performed microarray analysis of adipose derived stem cells after treatment with gibberellic acid, and identified six up-regulated genes, transcriptional factors. We transfected six genes into the human fetal fibroblast and cultured in the differentiation medium for salivary glands . Consequently, we found the amylase expression and changing in F-actin fibers. Therefore, we suggested that our data might be fruitful to establish the induction method for salivary gland differentiation.
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