development of functional regenerative bone as a stem cell reserver
| Project/Area Number |
25670847
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HOSHI Kazuto 東京大学, 医学部附属病院, 准教授 (30344451)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIHARA Yuko 東京大学, 医学(系)研究科(研究院), 特任助教 (50466744)
MORI Yoshiyuki 自治医科大学, 医学部, 教授 (70251296)
TAKATO Tsuyoshi 東京大学, 医学部附属病院, 教授 (90171454)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ステムセル・レザバー / 間葉系幹細胞 / 造血幹細胞 / 骨再生 / 再生医療 / 異所性骨化 / 異所性骨 / BMP-2 / VEGF |
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| Outline of Final Research Achievements |
For development of functional regenerative bone as a stem cell reserver, we examined the factor to maintain a mesenchymal stem cells and hematopoietic stem cells in rhBMP-2-induced regenerative bone, and its optimal dose. Based on this condition, we prepared a scaffold containing the factor to maintain hematopoietic stem cells within it, and also made a prototype of functional regenerative bone enclosing the rhBMP-2 into the scaffold, Finally, we established manufacturing condition of functional regenerative bone through animal experimental models using mice or others.
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] Open Journal of Stomatology Abe T, Abe M, Suenaga H, Kanno Y, Sugiyama S, Hoshi K: Preclinical and clinical research on bone and cartilage regenerative medicine in oral and maxillofacial region2014
Author(s)
Takato T, Mori Y, Fujihara Y, Asawa Y, Nishizawa S, Kanazawa S, Ogasawara T, Saijo T, Open Journal of Stomatology Abe T, Abe M, Suenaga H, Kanno Y, Sugiyama S, Hoshi K: Preclinical and clinical research on bone and cartilage regenerative medicine in oral and maxillofacial region
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Journal Title
Oral Sci Int
Volume: 11
Issue: 2
Pages: 45-51
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein(BMP) signaling.2013
Author(s)
Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, and Hoshi K
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Journal Title
J Cell Physiol
Volume: (in press)
Issue: 1
Pages: 163-71
DOI
Related Report
Peer Reviewed
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