| Project/Area Number |
25670847
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HOSHI Kazuto 東京大学, 医学部附属病院, 准教授 (30344451)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIHARA Yuko 東京大学, 医学(系)研究科(研究院), 特任助教 (50466744)
MORI Yoshiyuki 自治医科大学, 医学部, 教授 (70251296)
TAKATO Tsuyoshi 東京大学, 医学部附属病院, 教授 (90171454)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ステムセル・レザバー / 間葉系幹細胞 / 造血幹細胞 / 骨再生 / 再生医療 / 異所性骨化 / 異所性骨 / BMP-2 / VEGF |
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| Outline of Final Research Achievements |
For development of functional regenerative bone as a stem cell reserver, we examined the factor to maintain a mesenchymal stem cells and hematopoietic stem cells in rhBMP-2-induced regenerative bone, and its optimal dose. Based on this condition, we prepared a scaffold containing the factor to maintain hematopoietic stem cells within it, and also made a prototype of functional regenerative bone enclosing the rhBMP-2 into the scaffold, Finally, we established manufacturing condition of functional regenerative bone through animal experimental models using mice or others.
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