Functional analysis of sFRP1 and b-catenin for development of therapeutic agents on skeletal dysplasia
| Project/Area Number |
25670852
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical University (2014)
The University of Tokyo (2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAYASU Mari 東京大学, 医学部附属病院, 特任臨床医 (10610941)
KURABAYASHI Kumiko 東京大学, 医学部附属病院, 特任臨床医 (40586757)
KANNO Yuki 東京大学, 医学部附属病院, 助教 (80451813)
INAKI Ryoko 東京大学, 医学部附属病院, 助教 (90632456)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ｓFRP1 / b-catenin / ｂ－catenin / Wnt / sFRP1 |
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| Outline of Final Research Achievements |
We studied the functional analysis of sFRP1 and b-catenin in mice brain for development of therapeutic agents on skeletal dysplasia. In the results, sFRP1 and b-catenin were highly expression in the VZ of embryonic and postnatal cortices suggesting that sFRP1 may regulate b-catenin and neural stem cell development. Moreover, sFRP1 may promote neuronal migration by stimulating neurite growth.
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Report
(3 results)
Research Products
(4 results)
