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Functional analysis of sFRP1 and b-catenin for development of therapeutic agents on skeletal dysplasia

Research Project

Project/Area Number 25670852
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionTokyo Medical University (2014)
The University of Tokyo (2013)

Principal Investigator

KAWASE-KOGA Yoko  東京医科大学, 医学部, 講師 (10392408)

Co-Investigator(Kenkyū-buntansha) OKAYASU Mari  東京大学, 医学部附属病院, 特任臨床医 (10610941)
KURABAYASHI Kumiko  東京大学, 医学部附属病院, 特任臨床医 (40586757)
KANNO Yuki  東京大学, 医学部附属病院, 助教 (80451813)
INAKI Ryoko  東京大学, 医学部附属病院, 助教 (90632456)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordssFRP1 / b-catenin / b-catenin / Wnt / sFRP1
Outline of Final Research Achievements

We studied the functional analysis of sFRP1 and b-catenin in mice brain for development of therapeutic agents on skeletal dysplasia. In the results, sFRP1 and b-catenin were highly expression in the VZ of embryonic and postnatal cortices suggesting that sFRP1 may regulate b-catenin and neural stem cell development. Moreover, sFRP1 may promote neuronal migration by stimulating neurite growth.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2014 2013

All Presentation (4 results)

  • [Presentation] Clinical study of the complications at proximal segment with intraoral vertical ramus osteotomy (IVRO); related to the osteotomy line?2014

    • Author(s)
      Yoko Kawase-Koga, Yoshiyuki Mori, Yuki Kanno, Yasuyuki Fujii, Takafumi Susami, Kazuto Hoshi, and Tsuyoshi Takato
    • Organizer
      AAOMS 96th Annual Meeting
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, U.S.A.
    • Year and Date
      2014-09-08 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 下顎枝垂直骨切り術(IVRO)における近位骨片に関する偶発症の検討2014

    • Author(s)
      古賀陽子、森良之、藤居泰行、菅野勇樹、末永英之、安部貴大、 西條英人、井口隆人、岡安麻里、大久保和美、須佐美隆史、高戸毅
    • Organizer
      第24回日本顎変形症学会総会・学術大会
    • Place of Presentation
      アクロス福岡、福岡
    • Year and Date
      2014-06-10 – 2014-06-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 25 mmを超える上下顎不調和と下顎非対称を呈した片側性唇顎口蓋裂の1例2013

    • Author(s)
      古賀陽子ら
    • Organizer
      第23回日本顎変形症学会会総会・学術大会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 過去5年間の下顎枝垂直骨切り術(IVRO)症例における近位骨片の偏位に関する臨床的検討2013

    • Author(s)
      古賀陽子ら
    • Organizer
      第58回日本口腔外科学会総会・学術大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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