| Project/Area Number |
25670855
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Mie University |
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Principal Investigator |
MURATA TAKU 三重大学, 医学部附属病院, 講師 (80242965)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Kasumi 三重大学, 医学部附属病院, 助教 (20378368)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 唾液腺 / cAMP / phosphodiesterase / 鳥インフルエンザ / 唾液 |
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| Outline of Final Research Achievements |
There is possibility of the explosion infection (pandemic) by the mutation of avian influenza virus. Therefore, we studied relationship between phosphodiesterase (PDE) and antivirus salivary proteins. As the sublingual gland does not have action of the adrenergic nerve, we had thought that there was little PDE activity in the sublingual gland. However, the PDE activity in the sublingual gland was like other salivary glands. And it was suggested that there was the specific PDE action in the sublingual gland. In submandibular acini cells, PDE3 inhibitor stimulated the expressions of amylase and aquaporin. We did not found the difference knockout and wild mouse in the further detailed studies.
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