| Project/Area Number |
25670860
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Ehime University |
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Principal Investigator |
MURASE RYUICHI 愛媛大学, 医学部附属病院, 講師 (70452696)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Id / 脱ユビキチン化酵素 / USP-1 / 分化誘導療法 / Id-1 / 口腔扁平上皮癌 |
|---|
| Outline of Final Research Achievements |
The transcriptional factor Id is known to regulate several malignant phenotypes in oral cancers. In this study, we revealed that the expression of Id is mainly mediated by certain types of deubiquitinating enzymes, and that USP-1, known as one of deubiquitinases, promotes cell proliferation and invasion. Downregulation of USP-1 suppressed Id expression, which directly lead to tumor suppression in in vivo experiments. These results suggest that a certain type of deubiquitinases, which potentially modulate transcripitional factors, might be established as a novel therapeutic method for oral cancer patients.
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