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Investigation of microRNA as a biomarker in recurrence and metastasis of oral cancer

Research Project

Project/Area Number 25670867
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionHyogo Medical University

Principal Investigator

Urade Masahiro  兵庫医科大学, 医学部, 特別招聘教授 (70104883)

Co-Investigator(Kenkyū-buntansha) NOGUCHI Kazuma  兵庫医科大学, 医学部, 准教授 (50309473)
ZUSHI Yusuke  兵庫医科大学, 医学部, 助教 (80581206)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords口腔癌 / マイクロRNA / 原発巣 / 転移巣 / 培養癌細胞 / 患者血清 / バイオマーカー / 培養口腔癌細胞
Outline of Final Research Achievements

The aim of this study is to examine the expression of microRNA (miRNA) that exists in oral cancer tissues and serum, and is non-coding RNA regulating expression of oncogenes and tumor suppressor genes, and to investigate the possibility to become a biomarker of oral cancer.
The microRNA expression was examined using microarray for primary tumor, metastatic tumor, cultured tumor cells (OSCC) derived from lymph node metastasis, and serum of the first visit of the same tongue cancer patient. Consequently, it was found that miR-365a-5p and miR-4756-5p were down-regulated in all samples as compared to oral keratinocyte as control, and strongly involved in growth and invasiveness of OSCC. These results indicated that these two miRs are potent biomarker of oral cancer.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2014

All Presentation (2 results)

  • [Presentation] MicroRNA expression profiling in primary and metastatic lesions, its cultured cancer cells and serum of an oral cancer patient2014

    • Author(s)
      M.Urade, K.Noguchi, Y.Zushi, H.Sei, H.Kishimoto
    • Organizer
      22nd European Association of Cranio-Maxillo-Facial Surgery
    • Place of Presentation
      Prague Congress Center, Prague, (Czech Republic)
    • Year and Date
      2014-09-23 – 2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 口腔癌患者の原発巣、転移巣、培養癌細胞、血清におけるマイクロRNA2014

    • Author(s)
      浦出雅裕、野口一馬、頭司雄介、清 仁美、岸本裕充
    • Organizer
      第22回 欧州頭蓋顎顔面外科学会議
    • Place of Presentation
      プラハ、チェコスロバキア
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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