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Development of the therapeutic targets for salivary gland carcinoma using virtual pathology and antibody-based proteomics

Research Project

Project/Area Number 25670868
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionNational Cancer Center Japan

Principal Investigator

HONDA Kazufumi  独立行政法人国立がん研究センター, 研究所, ユニット長 (10260936)

Co-Investigator(Kenkyū-buntansha) MORI Taisuke  国立研究開発法人国立がん研究センター中央病院, 病理科 (00296708)
野村 武史  東京歯科大学, オーラルメディシン・口腔外科学講座, 教授 (60328268)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords唾液腺がん / 組織マイクロアレイ / プロテオミクス / 仮想病理画像 / 定量抗体プロテオミクス / 抗体基盤プロテオミクス / 画像解析ソフトウエア / 国際研究者交流 / 国際情報交換
Outline of Final Research Achievements

To identify the biomarker for decision of therapeutic strategy in salivary gland carcinoma, we made tissue microarray of the salivary gland carcinoma, and searched it by antibody-based proteomics. We identified overexpression of actiin-4 (ACTN4) that is associated with cancer metastasis in salivary gland carcinoma. To confirm the gene amplification of ACTN4, we investigated the copy number of ACTN4 by FISH analysis. FISH (fluorescence in situ hybridization) revealed that overall survival time of patients with gene amplification of ACTN4 was significantly shorter than it of patients with normal copy number. The multivariate Cox regression analysis revealed that gene amplification of ACTN4 remained as an independent prognostic factor. The gene amplification of ACTN4 is a potential prognostic biomarker for salivary gland carcinoma.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (48 results)

All 2015 2014 2013 Other

All Journal Article (27 results) (of which Peer Reviewed: 24 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (21 results) (of which Invited: 17 results)

  • [Journal Article] The Alternatively Spliced Actinin-4 Variant as a Prognostic Marker for Metastasis in Small-cell Lung Cancer.2015

    • Author(s)
      Okamoto N, Suzuki H, Kawahara K, Honda K, Miura N, Hirashima T, Tamiya M, Morishita N, Shiroyama T, Tanaka A, Tani E, Hamaguchi M, Kitani M, Yamada T, and Kawase
    • Journal Title

      Anticancer Res

      Volume: 35(3) Pages: 1663-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ACTN4 copy number increase as a predictive biomarker for chemoradiotherapy of locally advanced pancreatic cancer.2015

    • Author(s)
      Watanabe T, Ueno H, Watabe Y, Hiraoka N, Morizane C, Itami J, Okusaka T, Miura N, Kakizaki T , Kakuya T, Kamita M, Tsuchida A, Nagakawa Y, Wilber H, Yamada T and Honda K
    • Journal Title

      Br J Cancer

      Volume: Feb 17;112(4) Issue: 4 Pages: 704-13

    • DOI

      10.1038/bjc.2014.623

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] プロテオーム解析による膵癌診断方法の開発2015

    • Author(s)
      三 浦奈美、紙田正博、本田一文、山田哲司
    • Journal Title

      膵癌治療 up-to-date 2015

      Volume: 2015 Pages: 91-98

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Histological growth pattern of and alpha-actinin-4 expression in thyroid cancer.2014

    • Author(s)
      Tanaka N, Yamashita T, Yamamoto S, Matsunobu T, Tsuda H, Honda K, Yamada T, Tamai S, Shiotani A.
    • Journal Title

      Anticancer Res.

      Volume: Jun;34(6) Pages: 3157-63

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alternative mammalian target of rapamycin (mTOR) signal activation in sorafenib-resistant hepatocellular carcinoma cells revealed by array-based pathway profiling.2014

    • Author(s)
      Masuda M, Chen WY, Miyanaga A, Nakamura Y, Kawasaki K, Sakuma T, Ono M, Chen CL, Honda K, Yamada T
    • Journal Title

      Mol Cell Proteomics.

      Volume: Jun;13(6) Issue: 6 Pages: 1429-38

    • DOI

      10.1074/mcp.m113.033845

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome.2014

    • Author(s)
      Arai E, Sakamoto H, Ichikawa H, Totsuka H, Chiku S, Gotoh M, Mori T, Nakatani T, Ohnami S, Nakagawa T, Fujimoto H, Wang L, Aburatani H, Yoshida T, Kanai Y.
    • Journal Title

      Int J Cancer.

      Volume: On line Issue: 3 Pages: 613-22

    • DOI

      10.1002/cam4.214

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 臨床材料を用いたアレイ基盤プロテオミクスを用いた創薬標的・バイオマーカーの開発,2014

    • Author(s)
      小林信, 山田哲司, 本田一文
    • Journal Title

      医学のあゆみ

      Volume: 251 (10), Pages: 980-983

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 肺がんの予後予測と遺伝子シグナチャー (特集 がん分子診断のパラダイムシフト)2014

    • Author(s)
      山田哲司, 野呂林太郎, 本田一文
    • Journal Title

      最新医学

      Volume: 69 (12) Pages: 2512-2519

    • NAID

      40020289928

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Narrow-band imaging system with magnifying endoscopy for early oral cancer.2014

    • Author(s)
      Shibahara T, Yamamoto N, Yakushiji T, Nomura T, Sekine R, Muramatsu, K, Ohata, H.
    • Journal Title

      The -Bulletin of Tokyo Dental College.

      Volume: 55(2): Pages: 87-94

    • NAID

      130004868700

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular biological change in oral cancer, summary of our researches2014

    • Author(s)
      Yamamoto N, Onda T, Sugahara K, Nomura T, Shibahara, T.
    • Journal Title

      Japanese Dental Science Review

      Volume: 51(1): Issue: 1 Pages: 25-33

    • DOI

      10.1016/j.jdsr.2014.09.003

    • NAID

      50009645831

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔扁平上皮癌周囲に広がる上皮性異形成に対する切除範囲の決定法2014

    • Author(s)
      野村武史, 柴原孝彦.
    • Journal Title

      歯科学報

      Volume: 114(6) Pages: 195-202

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of EpCAM and prognosis in early-stage glottic cancer treated by radiotherapy2014

    • Author(s)
      Murakami N, Mori T, Yoshimoto S, Ito Y, Kobayashi K, Ken H, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Inaba K, Morota M, Sumi M, Itami J.
    • Journal Title

      Laryngoscope.

      Volume: Nov;124(11): Issue: 11 Pages: 431-436

    • DOI

      10.1002/lary.24839

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of PAX8 mouse monoclonal antibody in the diagnosis of thyroid, thymic, pleural, and lung tumors: a comparison with polyclonal PAX8 antibody.2014

    • Author(s)
      Toriyama A, Mori T, Sekine S, Yoshida A, Hino O, Tsuta K.
    • Journal Title

      Histopathology

      Volume: On line Issue: 4 Pages: 465-72

    • DOI

      10.1111/his.12405

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Secondary osteosarcoma developing 10 years after chemoradiotherapy for non-small-cell lung cancer.2014

    • Author(s)
      Yagishita S, Horinouchi H, Yorozu T, Kitazono S, Mizugaki H, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Mori T, Tsuta K, Sumi M, Tamura T.
    • Journal Title

      Jpn J Clin Oncol

      Volume: Feb;44(2): Issue: 2 Pages: 191-4

    • DOI

      10.1093/jjco/hyt192

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alternative mTOR signal activation in sorafenib-resistant hepatocellular carcinoma cells revealed by array-based pathway profiling.2014

    • Author(s)
      Masuda M, Chen WY, Miyanaga A, Nakamura Y, Kawasaki K, Sakuma T, Ono M, Chen CL, Honda K, Yamada T.
    • Journal Title

      Mol Cell Proteomics

      Volume: In press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] MicroRNA expression and functional profiles of osteosarcoma.2014

    • Author(s)
      Kobayashi E, Satow R, Ono M, Masuda M, Honda K, Sakuma T, Kawai A, Morioka H, Toyama Y, Yamada T.
    • Journal Title

      Oncology

      Volume: 86(2): Issue: 2 Pages: 94-103

    • DOI

      10.1159/000357408

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemical actinin-4 expression in infiltrating gliomas: association with WHO grade and differentiation.2014

    • Author(s)
      Fukushima S, Yoshida A, Honda K, Maeshima AM, Narita Y, Yamada T, Shibui S, Tsuda H.
    • Journal Title

      Brain Tumor Pathol.

      Volume: Jan;31(1): Issue: 1 Pages: 11-6

    • DOI

      10.1007/s10014-013-0139-z

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Basic study of soft tissue augmentation by adipose-inductive biomaterial2014

    • Author(s)
      Yazawa M, Mori T, Kishi K
    • Journal Title

      Journal of Biomedical Materials Research: Part B - Applied Biomaterials.

      Volume: In press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome2014

    • Author(s)
      Arai E, Sakamoto H, Ichikawa H, Totsuka H, Chiku S, Gotoh M, Mori T, Nakatani T, Ohnami S, Nakagawa T, Fujimoto H, Wang L, Aburatani H, Yoshida T, Kanai Y.
    • Journal Title

      Int J Cancer

      Volume: 135 Issue: 6 Pages: 1330

    • DOI

      10.1002/ijc.28768

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histopathological characteristics of hypervascular cholangiocellular carcinoma as an early stage of cholangiocellular carcinoma.2014

    • Author(s)
      Sato Y, Ojima H, Onaya H, Mori T, Hiraoka N, Kishi Y, Nara S, Esaki M, Shimada
    • Journal Title

      Hepatol Res.

      Volume: Sept 6 Issue: 11 Pages: 1119-1129

    • DOI

      10.1111/hepr.12236

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Junctional Rab13-binding protein (JRAB) re requires cell spreading via filamins.2013

    • Author(s)
      Sakane, A
    • Journal Title

      Genes Cells

      Volume: 18 Issue: 9 Pages: 810-822

    • DOI

      10.1111/gtc.12078

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Soluble interleukin-6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy.2013

    • Author(s)
      Makuuchi Y, Honda K, Osaka Y, Kato K, Kojima T, Daiko H, Igaki H, Ito Y, Hoshino S, Tachibana S, Watanabe T, Furuta K, Sekine S, Umaki T, Watabe Y, Miura N, Ono M, Tsuchida A, Yamada T.
    • Journal Title

      Cancer Sci.

      Volume: Aug;104(8): Issue: 8 Pages: 1045-51

    • DOI

      10.1111/cas.12187

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: A clue to the histogenesis and diagnosis2013

    • Author(s)
      Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima M, Akazawa C, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H
    • Journal Title

      Modern Pathology

      Volume: Aug;26(8): Issue: 8 Pages: 1041-50

    • DOI

      10.1038/modpathol.2013.54

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distinct outcome of stage I lung adenocarcinoma with ACTN4 cell motility gene amplification.2013

    • Author(s)
      Noro R1, Honda K, Tsuta K, Ishii G, Maeshima AM, Miura N, Furuta K, Shibata T, Tsuda H, Ochiai A, Sakuma T, Nishijima N, Gemma A, Asamura H, Nagai K, Yamada T.
    • Journal Title

      Ann Oncol

      Volume: Oct;24(10): Issue: 10 Pages: 2594-600

    • DOI

      10.1093/annonc/mdt293

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stem cell self-renewal factors Bmi1 and HMGA2 in head and neck squamous cell carcinoma: clues for diagnosis.2013

    • Author(s)
      Yamazaki H, Mori T, Yazawa M, Maeshima AM, Matsumoto F, Yoshimoto S, Ota Y, Kaneko A, Tsuda H, Kanai Y.
    • Journal Title

      Lab Invest.

      Volume: Dec;93(12): Issue: 12 Pages: 1331-8

    • DOI

      10.1038/labinvest.2013.120

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms.2013

    • Author(s)
      Nishikawa G, Sekine S, Ogawa R, Matsubara A, Mori T, Taniguchi H, Kushima R, Hiraoka N, Tsuta K, Tsuda H, Kanai Y.
    • Journal Title

      Br J Cancer.

      Volume: Mar 5;108(4): Issue: 4 Pages: 951-8

    • DOI

      10.1038/bjc.2013.47

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bisphosphonate-related osteonecrosis of jaw (BRONJ) in Japanese population: a case series of 13 patients at our clinic.2013

    • Author(s)
      Nomura T
    • Journal Title

      Bull Tokyo Dent Coll.

      Volume: 54 Pages: 117-125

    • NAID

      130004868681

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 「口腔がん治療の均てん化・標準化」特別講演 「がん個別化医療・早期診断バイオマーカーの開発と実用化」2015

    • Author(s)
      本田一文
    • Organizer
      文部科学省 がんプロフェッショナル養成基盤推進プラン-高度がん医療開発を先導する専門家の養成-4大学合同事業:慶應義塾大学・東海大学・東京歯科大学・信州大学 公開講座
    • Place of Presentation
      新宿NSビル東京都
    • Year and Date
      2015-02-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 口腔癌の性質を反映する分子診断2015

    • Author(s)
      森 泰昌
    • Organizer
      文部科学省 がんプロフェッショナル養成基盤推進プラン-高度がん医療開発を先導する専門家の養成-4大学合同事業:慶應義塾大学・東海大学・東京歯科大学・信州大学 公開講座
    • Place of Presentation
      新宿NSビル東京都
    • Year and Date
      2015-02-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「シスプラチン耐性克服に向けた創薬を目指して-進行卵巣がんのシスプラチン耐性腫瘍に対する創薬-」2015

    • Author(s)
      本田一文
    • Organizer
      日本医療研究開発機構設立準備委員会、医薬基盤研、理化学研究所、産業総合研究所主催【オールジャパンの創薬支援-創薬立国日本に向けて】創薬支援ネットワーク・シンポジウム
    • Place of Presentation
      グランフロント大阪 ナレッジシアター 大阪市
    • Year and Date
      2015-01-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] トランスオミクスワークショップ 「プロテオミクス総括」2014

    • Author(s)
      本田一文
    • Organizer
      第1回トランスオミクス研究会
    • Place of Presentation
      東北メディカルメガバンク 仙台市
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 頭頸部における稀少がんの病理2014

    • Author(s)
      森 泰昌
    • Organizer
      第59回 日本口腔外科学会総会 シンポジウム
    • Place of Presentation
      幕張国際会議場 千葉市
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 唾液腺がん組織マイクロアレイを用いた予後予測バイオマーカーの同定2014

    • Author(s)
      本田一文
    • Organizer
      日本口腔外科学会・日本口腔病理学会・日本歯科放射線学会、口腔3学会シンポジウム
    • Place of Presentation
      幕張国際会議場 千葉市
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Possible Detection of Early-Stage Pancreatic Cancer by Measuring Plasma Apolipoprotein-AII isoforms2014

    • Author(s)
      Kazufumi Honda1, Michimoto Kobayashi2, Giman Jung2, Tesshi Yamada1
    • Organizer
      Scientific Workshop, National Cancer Institute (NCI), Early Detection Research Network (EDRN),
    • Place of Presentation
      Hyatt Regency Bethesda ML, USA.
    • Year and Date
      2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 膵臓がんの早期発見;膵がん検診の効率化を目指した血液バイオマーカーの実用化-2014

    • Author(s)
      本田一文
    • Organizer
      パープルリボン医療セミナージャパン東京2014
    • Place of Presentation
      星陵会館
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「がん個別化医療バイオマーカーの開発と実用化」2014

    • Author(s)
      本田一文
    • Organizer
      第62回重粒子医科学センター研究交流会
    • Place of Presentation
      独立行政法人 放射線医学研究所 千葉市
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] がん個別化医療選択のためのバイオマーカー開発と実用化2014

    • Author(s)
      本田一文
    • Organizer
      27回青森呼吸器研究会 特別講演
    • Place of Presentation
      ホテル青森 青森市
    • Year and Date
      2014-08-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] アレイ技術・抗体基盤・質量分析基盤プロテオミクスの融合-がんバイオマーカー探索と検証に向けて-2014

    • Author(s)
      本田一文
    • Organizer
      日本プロテオーム学会2014年大会 シンポジウム
    • Place of Presentation
      つくば国際会議場 つくば市
    • Year and Date
      2014-07-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Gene amplification of ACTN4 is a predictor of cancer metastasis.2014

    • Author(s)
      Kazufumi Honda, and Tesshi Yamada.
    • Organizer
      15th International Biennial Congress of the Metastasis Research Society
    • Place of Presentation
      German Cancer Research Center. Dkfz. Heidelberg Germany.
    • Year and Date
      2014-06-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Actinin-4 expression is a predictive biomarker for late metastasis of cervical lymph nodes in early-stage tongue cancer2013

    • Author(s)
      Yukio Watabe1,2, Kazufumi Honda1, Taisuke Mori3, Nami Miura1, Takeshi Nomura2, Takahiko Shibahara2, and Tesshi Yamada1
    • Organizer
      21st international conference on oral and maxillofacial surgery-
    • Place of Presentation
      Barcelona Spein
    • Related Report
      2013 Research-status Report
  • [Presentation] Actinin-4 is a predictive biomarker for late metastasis of stage I-II tongue cancer

    • Author(s)
      Kazufumi Honda, Yukio Watabe, Takeshi Nomura, Takahiko Shibahara, Wilber Huang, Wei-Yu Chen, Chi-Long Chen Tesshi Yamada
    • Organizer
      2014 Annual Congress of ROC Association of Oral and Maxillofacial Surgeons, Taiwan, March 8th 2014.
    • Place of Presentation
      Tainan Taiwan
    • Related Report
      2013 Research-status Report
  • [Presentation] Rapid biomarker validation by high-density plasma protein array

    • Author(s)
      Kazufumi Honda, Masaya Ono, Masahiro Kamita, Tomohiko Kakizaki, Tesshi Yamada
    • Organizer
      3rd Global Reverse Phase Protein Microarray Workshop
    • Place of Presentation
      Kobe Japan
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 難治がん早期診断血液バイオマーカーの開発と多施設共同研究による迅速検証法の構築

    • Author(s)
      本田一文、山田哲司
    • Organizer
      第60回日本臨床検査医学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] シスタチオニンγリアーゼ(CSE)の阻害は、シスプラチンの効果を増強する

    • Author(s)
      本田一文
    • Organizer
      第1回 がんと代謝研究会
    • Place of Presentation
      鶴岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] The mechanism of resistance for chemotherapy in advanced stage of ovarian cancer

    • Author(s)
      Kazufumi Honda1, Sohei Yamamoto2, Hitoshi Tsuda2,3, Nami Miura1, Mitsuyo Omura4, Yoshihiro Izumi5, Masashi Takano6, Takahiro Kasamatsu7, Masaru Yoshida5, Makoto Suematsu4 & Tesshi Yamada1
    • Organizer
      第86回日本生化学学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 個別化医療バイオマーカーの同定と実用化

    • Author(s)
      本田一文
    • Organizer
      第58回日本口腔外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 肺がんの相別化バイオマーカーについて

    • Author(s)
      本田一文
    • Organizer
      The 4th meeting Society of Basic and Translational Research in Oncology and Respirology
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] がん個別化医療選択のためのバイオマーカー開発と実用化

    • Author(s)
      本田一文
    • Organizer
      国際癌治療増感研究会 次世代がん治療推進専門家養成プラン シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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