| Project/Area Number |
25670873
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
NOMURA Ryota 大阪大学, 歯学研究科(研究院), 准教授 (90437385)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Michiyo 岡山大学, 医歯(薬)学総合研究科, 教授 (30359848)
ASAI Fumitoshi 麻布大学, 獣医学部, 教授 (00511677)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯周病原性細菌 / 伴侶動物 / Porphyromonas gulae / 犬 / FimA / 僧帽弁閉鎖不全症 / 線毛型 / 伝播 / PCR 法 / リコンビナントタンパク / カイコモデル / 歯周病 |
|---|
| Outline of Final Research Achievements |
Information regarding transmission of periodontitis-related bacterial species between dogs and their owners is limited. In the present study, we detected periodontitis-related species in both dogs and their owners including Porphyromonas gulae, known to be a major bacterial pathogen of periodontitis in dogs. P. gulae possesses approximately 41-kDa filamentous appendages (FimA), which have been classified into three major genotypes; A, B, and C. Our results showed that P. gulae with FimA genotype C was associated with mitral regurgitation in dogs.
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