| Project/Area Number |
25670882
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Tomoyuki 新潟大学, 医歯学総合病院, 医員 (30447635)
中村 昇太 大阪大学, 微生物病研究所, 助教 (90432434)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Shota 大阪大学, 微生物病研究所, 助教 (90432434)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯周病 / 全身疾患 / 腸内細菌叢 / Porhyromonas gingivalis / メタボリックシンドローム / ペリオドンタルメディスン / Porphyromonas gingivalis / 腸内細菌 / 内毒素血症 |
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| Outline of Final Research Achievements |
We revealed that oral adinistration of P. gingivalis induced the inflammatory changes in the adipose tissue, liver, and gut. These chages were associated with insulin resistance. Furthermore, oral administration of P. gingivalis induced an alteration of the gut microbiota, a decreased gut barrier function, and an elevation of blood endotoxin levels in a mouse model. Our study showing that swallowing large amounts of oral bacteria alters the gut microbiota provides a rationale for the biological basis of a causal association between periodontal disease and systemic diseases.
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