Reversing Aging: Regeneration of Aged Tissues using Adult Stem Cells Inside a Tissue exposed to Hydrogen Sulfide
Project/Area Number |
25670898
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Social dentistry
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Research Institution | The Nippon Dental University |
Principal Investigator |
Yaegaki Ken 日本歯科大学, 生命歯学部, 教授 (40166468)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 再生医療 / 若返り / 膵臓 / 肝臓 / β細胞 / インスリン / 歯髄 / 幹細胞 / tooth / stem cell / insulin / pancreas / 硫化水素 / 骨髄幹細胞 / 乳歯幹細胞 |
Outline of Final Research Achievements |
This study had shown that hydrogen sulfide increases the number of b-cells and also insulin secretion from the cells reproduced from human tooth pulp. However high glucose decreased the number of cells and insulin secretion because of apoptosis. Hence we revised the protocol of regeneration of b-cells from human tooth pulp, and increased hydrogen sulfide concentration to 10 times, and glucotoxicities were almost disappeared, and the cells produced large amount of insulin. Thus exposing human tissue to hydrogen sulfide may cause reversing aging of the pancreas.
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Report
(4 results)
Research Products
(7 results)