A preliminary study of an ecological treatment for Bacterial Vaginosis by activated charcoal vaginal washing

• Project/Area Number: 25670951
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Clinical nursing
• Research Institution: Iwate Medical University
• Principal Investigator: Tominaga Kunihiko 岩手医科大学, 医学部, 講師 (50254032)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 細菌性腟症 / 活性炭洗浄法 / 乳酸菌 / バクテロイデス / 薬用活性炭洗浄法 / 危険因子 / 防御因子 / 薬用活性炭による腟内洗浄療法 / Bacteroides / 新種のLactobacillus属 / 腟内細菌叢 / 抗生物質 / 薬用活性炭 / 臨床的有益性 / PCR-DGGE解析法

Outline of Final Research Achievements

The　difference　of　therapeutic　effect　of　the　both　group　(activated　charcoal　vs.　metronidazole)　was　not　statistically　significant　(P=0.241,　Fisher's　exact　test).Results　from　multiple　logistic　regression　analysis　showed　there　were　no　significant　independent　prognostic　factors　for　the　effect　of　treatment　(p>0.05).　Bacteroides　species　which　has　long　been　acknowledged　as　a　predominant　species　of　BV,　was　not　identified　at　all..　The　absence　of　Lactobacillus　species　was　observed　in　the　26　%　of　the　subjects.　In　the　additional　survey　for　healthy　volunteers　showed　that　96%　of　the　subjects　were　without　Bacteroides　species　in　the　vagina.