| Budget Amount *help |
¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
(1)Traversing combinatorial space with brand-and-bound search and rigorous multiple testing correction. A combinatorial space spanned by combination of genes contains a large number of false positives. We devised to remove them by employing Tarone’s correction, which resulted in a faster search with higher statistical power.
(2)Estimating the size of combinatorial space by kernel methods: In our computational experiments equipped with polynomial kernels and kernel ridge regression, we have shown that detection of up-to-six degrees interaction was possible. By applying the same method to mouse genotype/phenotype data, we have successfully detected the region in a chromosome that harbors causal genes.
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