Higher order cognitive functions and their neural bases, and genetic, environmental and physical factors that affect them

• Project/Area Number: 25700012
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Cognitive science
• Research Institution: Tohoku University
• Principal Investigator: TAKEUCHI Hikaru 東北大学, 加齢医学研究所, 准教授 (50598399)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000); Fiscal Year 2014: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000); Fiscal Year 2013: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
• Keywords: 高次認知機能 / 神経系 / 脳イメージング / 可塑性 / 認知訓練

Outline of Final Research Achievements

We investigated the neural mechanisms of individual differences of higher order cognitive functions, genetic polymorphisms, and body mineral that affect them, and effects of higher order cognitive training on neural mechanisms. Through longitudinal studies, we revealed the effects of training on multitasking and training on working memory on various neural mechanisms. Through cross-sectional studies, we investigated higher cognitive functions such as creativity and neural mechanisms underlying them, genetic polymorphism, and body mineral that affect them.

Research Products

• [Journal Article] Brain structures in the sciences and humanities. (2015)
  • Author(s): Takeuchi H, Taki Y, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Sassa Y, Kawashima R.
  • Journal Title: Brain Structure and Function Volume: Epub ahead of publication Issue: 6 Pages: 1-11
  • DOI: 10.1007/s00429-014-0857-y
  • Peer Reviewed / Open Access
• [Journal Article] The structure of the amygdala associates with human sexual permissiveness: evidence from voxel-based morphometry. (2015)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R.
  • Journal Title: Human Brain Mapping Volume: 36 Issue: 2 Pages: 440-448
  • DOI: 10.1002/hbm.22638
  • Peer Reviewed / Open Access
• [Journal Article] Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity-related temperaments in young healthy adults (2015)
  • Author(s): Takeuchi H, Taki Y, Sekiguchi A, Hashizume H, Nouchi R, Sassa Y, Kotozaki Y, Miyauchi CM, Yokoyama R, Iizuka K, Nakagawa S, Nagase T, Kunitoki K, Kawashima R.
  • Journal Title: Human Brain Mapping Volume: 36 Issue: 5 Pages: 1808-1827
  • DOI: 10.1002/hbm.22739
  • Peer Reviewed / Open Access
• [Journal Article] Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele (2015)
  • Author(s): Takeuchi H, Tomita H, Taki Y, Kikuchi Y, Ono C, Yu Z, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Kunitoki K, Sassa Y, Kawashima R
  • Journal Title: Neuroimage Volume: 110 Pages: 124-135
  • DOI: 10.1016/j.neuroimage.2015.01.053
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Working memory training impacts the mean diffusivity in the dopaminergic system. (2014)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R.
  • Journal Title: Brain Structure and Function Volume: Epub ahead of publication Issue: 6 Pages: 1-11
  • DOI: 10.1007/s00429-014-0845-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association between resting-state functional connectivity and empathizing/systemizing. (2014)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Sekiguchi A, Hashizume H, Sassa Y, Kotozaki Y, Miyauchi CM, Yokoyama R, Iizuka K, Nakagawa S, Nagase T, Kunitoki K, Kawashima R.
  • Journal Title: Neuroimage Volume: 99 Pages: 312-322
  • DOI: 10.1016/j.neuroimage.2014.05.031
  • Peer Reviewed / Open Access
• [Journal Article] Creativity measured by divergent thinking is associated with two axes of autistic characteristics. (2014)
  • Author(s): Takeuchi H, Taki Y, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Sassa Y, Kawashima R.
  • Journal Title: Frontiers in Psychology Volume: 5 Pages: 1-8
  • DOI: 10.3389/fpsyg.2014.00921
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Working memory training improves emotional states of healthy individuals. (2014)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R.
  • Journal Title: Frontiers in Systems Neuroscience Volume: 8 Pages: 1-14
  • DOI: 10.3389/fnsys.2014.00200
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association between gray matter volume in the caudate nucleus and financial extravagance : findings from voxel-based morphometry (2014)
  • Author(s): Yokoyama R, Nozawa T, Takeuchi H, Taki Y, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Shinada T, Yamamoto Y, Hanawa S, Araik T, Hashizume H, Kunitoki K, Hanihara M, Sassa Y, Kawas hima R
  • Journal Title: Neuroscience Letters Volume: 563 Pages: 28-32
  • DOI: 10.1016/j.neulet.2014.01.026
  • Peer Reviewed
• [Journal Article] Association of hair iron levels with creativity and psychological variables related to creativity. (2013)
  • Author(s): Takeuchi H, Taki Y, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Kunitoki K, Sassa Y, Kawashima R.
  • Journal Title: Frontiers in Human Neuroscience Volume: 7 Pages: 875-875
  • DOI: 10.3389/fnhum.2013.00875
  • Peer Reviewed
• [Journal Article] Effects of multitasking-training on gray matter structure and resting state neural mechanisms. (2013)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R.
  • Journal Title: Human Brain Mapping Volume: Epub ahead of publication Issue: 8 Pages: 1-15
  • DOI: 10.1002/hbm.22427
  • Peer Reviewed
• [Presentation] Effects of working memory-training on apparent diffusion coefficient of dopaminergic system. (2013)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R
  • Organizer: Society for Neuroscience 43nd Annual Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] 平等主義的性役割態度と脳の局所灰白質濃度の関連 (2013)
  • Author(s): 竹内光
  • Organizer: 日本パーソナリティ心理学会第22回大会, 千葉
  • Place of Presentation: 千葉
• [Presentation] The effects of working memory training on neural systems (2013)
  • Author(s): Takeuchi H, Taki Y, Kawashima R
  • Organizer: The 121st American Psychological Association Annual Convention
  • Place of Presentation: Honolulu, Hawaii, US
  • Invited