| Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|
|---|
| Outline of Final Research Achievements |
ATR is a kinase that regulates the DNA damage response and maintains genome stability. ATR has been shown to respond to a wider range of DNA damage and exhibit diverse functions. In this study, we aimed to clarify the mechanism underlying DNA structure-dependent activation of ATR and to identify the direct substrate of ATR. As a result, we found a novel ATR activation mechanism at the DNA double strand break site. We also made analog susceptible ATR mutants and successfully detected and identified many unknown substrates.
|
