Accumulation features and blood-brain transfer of organohalogen metabolites in mammals and effects on thyroid hormones homeostasis

• Project/Area Number: 25701014
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Environmental risk control and evaluation
• Research Institution: Ehime University
• Principal Investigator: Nomiyama Kei 愛媛大学, 沿岸環境科学研究センター, 准教授 (30512686)
• Co-Investigator(Renkei-kenkyūsha): TANABE Shinsuke 愛媛大学, 沿岸環境科学研究センター, 教授 (60116952) ; KUNISUE Tatsuya 愛媛大学, 沿岸環境科学研究センター, 教授 (90380287)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000); Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 有機ハロゲン化合物 / 水酸化代謝物 / 体内動態 / 脳 / 蓄積 / 甲状腺ホルモン / 毒性 / 野生生物 / PCBs / 脳移行 / イヌ / メタボローム / プロテオーム / ミトコンドリア / 代謝 / OH-PCBs / ハロゲン化フェノール類 / 動態

Outline of Final Research Achievements

Wildlife are chronically exposed of and bioaccumulate environmental contaminants such as PCBs and PBDEs, as well as their metabolic products (OH-PCBs and OH-PBDEs). A part of OH-PCBs and OH-PBDEs congeners structurally resemble thyroid hormones which are essential for normal brain development. Over the past decade, in vitro and in vivo studies on rodents and human epidemiological studies have been revealed the link between the exposure of OH-PCBs and/or OH-PBDEs and effects on the brain function and development. However, there are only few reports on the levels of the hydroxylated metabolites in the brains of terrestrial and marine mammals.
In this study, residual levels and patterns of PCBs, PBDEs, OH-PCBs and OH-PBDEs in the blood and brain of finless porpoises, dog, cat and Japanese monkey. The levels in the brain were compared to the laboratory determined effect threshold levels of OH-PCBs and OH-PBDEs, and possible effects on the wildlife are discussed.

Research Products

• [Int'l Joint Research] 韓国安全性評価研究所(韓国)
• [Journal Article] Organohalogen compounds in pet dog and cat: Do pets biotransform natural brominated products in food to harmful hydroxlated substances? (2016)
  • Author(s): Mizukawa H, Nomiyama K, Nakatsu S, Iwata H, Yoo J, Kubota A, Yamamoto M, Ishizuka M, Ikenaka Y, Nakayama M.M.S, Kunisue T, Tanabe S
  • Journal Title: Environmental Science & Technology Volume: 50 Issue: 1 Pages: 444-452
  • DOI: 10.1021/acs.est.5b04216
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] In vitro and in silico analyses for predicting hepatic cytochrome p450-dependent metabolic potencies of polychlorinated biphenyls in the Baikal seal (2015)
  • Author(s): Jean Yoo, Masashi Hirano, Hazuki Mizukawa, Kei Nomiyama, Tetsuro Agusa, Eun-Young Kim, Shinsuke Tanab, Hisato Iwata
  • Journal Title: Environmental Science and Technology Volume: 49 Issue: 24 Pages: 14588-14596
  • DOI: 10.1021/acs.est.5b03890
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Uptake and tissue distribution of pharmaceuticals and personal care products in wild fish from treated-wastewater-impacted streams (2015)
  • Author(s): Tanoue, R., Nomiyama, K., Nakamura, H., Kim, J. W., Isobe, T., Shinohara, R., Kunisue, T. and Tanabe, S.
  • Journal Title: Environmental Science and Technology Volume: 49(19) Issue: 19 Pages: 11649-11658
  • DOI: 10.1021/acs.est.5b02478
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] UGT Xenobiotic metabolizing activity and genetic evolution in Pinniped species (2015)
  • Author(s): Kakehi M, Ikenaka Y, Nakayama M.M.S, Kawai Y.K, Watanabe K.P, Mizukawa H, Nomiyama K, Tanabe S, Ishizuka M
  • Journal Title: Toxicological Sciences Volume: 147 Issue: 2 Pages: 360-369
  • DOI: 10.1093/toxsci/kfv144
  • NAID: 120005817898
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Residue profiles of anthropogenic and naturally produced organohalogen compounds and thyroid hormone levels in human serum from e-waste recycling sites in Vietnam. (2015)
  • Author(s): Eguchi, A., Nomiyama, K., Tue, N.M., Trang, P.T.K., Viet, P.H., Takahashi, S., Tanabe, S.
  • Journal Title: Environmental Research Volume: 137 Pages: 440-449
  • DOI: 10.1016/j.envres.2015.01.007
  • Peer Reviewed
• [Journal Article] Organohalogens and their hydroxylated metabolites in the blood of pigs from an open waste dumping site in south India: Association with hepatic cytochrome P450 (2015)
  • Author(s): Mizukawa H, Nomiyama K, Kunisue T, Watanabe MX, Subramanian A, Iwata H, Ishizuka M, Tanabe S
  • Journal Title: Environ Res Volume: 138 Pages: 255-263
  • DOI: 10.1016/j.envres.2015.02.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Toxicological Assessment of Polychlorinated Biphenyls and Their Metabolites in the Liver of Baikal Seal (Pusa sibirica). (2014)
  • Author(s): Nomiyama K, Hirakawa S., Eguchi A., Kanbara C., Imaeda D., Yoo J., Kunisue T., Kim E.Y, Iwata H, Tanabe S.
  • Journal Title: Environmental Science and Technology Volume: 48 Issue: 22 Pages: 13530-13539
  • DOI: 10.1021/es5043386
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Blood levels of polychlorinated biphenyls and their hydroxylated metabolites in Baikal seals (Pusa sibirica): Emphasis on interspecies comparison, gender difference and association with blood thyroid hormone levels (2014)
  • Author(s): Imaeda D., Nomiyama K., Kunisue T., Iwata H., Tsydenova O., Amano M., Petrov E.A., Batoev V.B, Tanabe S.
  • Journal Title: Chemosphere Volume: 114 Pages: 1-8
  • DOI: 10.1016/j.chemosphere.2014.03.089
  • Peer Reviewed
• [Journal Article] Simultaneous Determination of Polar Pharmaceuticals and Personal Care Products in Biological Organs and Tissues (2014)
  • Author(s): Rumi Tanoue, Kei Nomiyama, Haruna Nakamura, Terutake Hayashi, Joon-Woo Kim, Tomohiko Isobe, Ryota Shinohara, Shinsuke Tanabe
  • Journal Title: Journal of Chromatography A Volume: 1355 Pages: 193-205
  • DOI: 10.1016/j.chroma.2014.06.016
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Simultaneous detection of multiple hydroxylated polychlorinated polyc hlorinated biphenyls from a complex tissue matrix using gas chromat ography / isotope dilution mass spectrometry accumulation of hydroxy lated polychlorinated biphenyls (2014)
  • Author(s): Akifumi Eguchi, Kei Nomiyama, Mari Ochiai, Hazuki Mizukawa, Yasuko Nagano, Katsuhiro Nakagawa, Kouki Tanaka, Haruhiko Miyagawa, Shinsuke Tanabe.
  • Journal Title: Talanta Volume: 118 Pages: 253-261
  • DOI: 10.1016/j.talanta.2013.10.031
  • Peer Reviewed
• [Journal Article] Accumulation of hydroxylated polychlorinated biphenyls (OH-PCBs) and implications for PCBs metabolic capacities in three porpoise species (2013)
  • Author(s): Man Ochiai
  • Journal Title: Chemosphere Volume: (in press) Issue: 7 Pages: 803-810
  • DOI: 10.1016/j.chemosphere.2013.04.024
  • Peer Reviewed
• [Journal Article] Halogenated phenolic contaminants in the blood of marine mammals from Japanese coastal waters (2013)
  • Author(s): Kei Nomiyama, Chika Kanbara, Mari Ochiai, Akifumi Eguchi, Hazuki Mizukawa, Tomohiko Isobe, Takashi Matsuishi, Tadasu K. Yamada, Shinsuke Tanabe
  • Journal Title: Marine Environmental Research Volume: 93 Pages: 15-22
  • DOI: 10.1016/j.marenvres.2013.08.016
  • Peer Reviewed
• [Presentation] Uptake and tissue distribution of pharmaceuticals and personal care products in wild fish from treated-waste water impacted streams (2016)
  • Author(s): Rumi Tanoue,Kei Nomiyama,Haruna Nakamura,Joon-Woo Kim,Tomohiko Isobe,Ryota Shinohara,Tatsuya Kunisue,Shinsuke Tanabe
  • Organizer: International Symposium on Environmental Chemistry and Toxicology - To Accelerate a Global Network of Environmental Researchers
  • Place of Presentation: Ehime Univ. Matsuyama, Japan
  • Year and Date: 2016-03-19
  • Int'l Joint Research
• [Presentation] Biotransformation potencies of polychlorinated biphenyls in cats (2016)
  • Author(s): Hazuki Mizukawa,Misaki Maehara,Nozomu Yokoyama,Osamu Ichii,Mitsuyoshi Takiguchi,Kei Nomiyama,Yoshinori Ikenaka,Shouta M. M. Nakayama,Shinsuke Tanabe,Mayumi Ishizuka
  • Organizer: International Symposium on Environmental Chemistry and Toxicology -To Accelerate a Global Network of Environmental Researchers
  • Place of Presentation: Ehime Univ. Matsuyama, Japan
  • Year and Date: 2016-03-19
  • Int'l Joint Research
• [Presentation] Elucidation of accumulated status of bioaccumulated organohalogen compounds in the finless porpoise from Seto Inland Sea (2016)
  • Author(s): Kazutaka Motogi,Kei Nomiyama,Akitoshi Goto,Mari Ochiai,Yuko Tajima,Tadasu K.Yamada,Tomohiko Isobe,Tatsuya Kunisue,Shinsuke Tanabe
  • Organizer: International Symposium on Environmental Chemistry and Toxicology -To Accelerate a Global Network of Environmental Researchers
  • Place of Presentation: Ehime Univ. Matsuyama, Japan
  • Year and Date: 2016-03-19
  • Int'l Joint Research
• [Presentation] Toxicological assessment of PCBs and OH-PCBs in cat using metabolomics approach (2016)
  • Author(s): Hiroyuki Nishikawa,Kei Nomiyama,Akifumi Eguchi,Hazuki Mizukawa,Mayumi Ishizuka,Yoshinori Ikenaka,Shouta M. M. Nakayama,Shinsuke Tanabe
  • Organizer: International Symposium on Environmental Chemistry and Toxicology-To Accelerate a Global Network of Environmental Researchers
  • Place of Presentation: Ehime Univ. Matsuyama, Japan
  • Year and Date: 2016-03-19
  • Int'l Joint Research
• [Presentation] Toxicological assessment of polychlorinated biphenyls and their metabolites in the Baikal seal (Pusa sibirica) (2015)
  • Author(s): Kei Nomiyama, Shusaki Hirakawa, Chika Kanbara, Daisuke Imaeda, Jean Yoo, Tatsuya Kunisue, Eun-Young Kim, Hisato Iwata, Shinsuke Tanabe
  • Organizer: Leading Symposium on Chemical Hazard and Adaptability in Animals - The Current Challenge of Young Researchers
  • Place of Presentation: Hokkaido Univ. Sapporo, Japan
  • Year and Date: 2015-12-11
  • Int'l Joint Research / Invited
• [Presentation] Impact of anthropogenic and naturally occurring brominated compounds in veterinary field. (2015)
  • Author(s): Hazuki Mizukawa, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M. Nakayama, Kei Nomiyama, Misaki Maehara, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: Leading Symposium on Chemical Hazard and Adaptability in Animals - The Current Challenge of Young Researchers
  • Place of Presentation: Hokkaido Univ. Sapporo, Japan
  • Year and Date: 2015-12-11
  • Int'l Joint Research
• [Presentation] イヌ脳に及ぼす PCBs の影響：プロテオーム解析による評価 (2015)
  • Author(s): 高口倖暉・野見山 桂Claret Lauan Maria・Jean Yoo・水川葉月・岩田久人・国末達也・田辺信介
  • Organizer: 環境ホルモン学会第18回研究発表会
  • Place of Presentation: 栃木県下野市自治医科大学
  • Year and Date: 2015-12-10
• [Presentation] イヌ脳中 PCBs, OH-PCBs の毒性影響評価：メタボロミクスアプローチ (2015)
  • Author(s): 野見山 桂・江口哲史・水川葉・Jean Yoo・高口倖暉・山本泰央・国末達也・岩田久人・田辺信介
  • Organizer: 環境ホルモン学会第18回研究発表会
  • Place of Presentation: 栃木県下野市自治医科大学
  • Year and Date: 2015-12-10
• [Presentation] ペット動物における有機ハロゲン化合物および水酸化代謝物の曝露実態と甲状腺ホルモン恒常性へ及ぼす影響環 (2015)
  • Author(s): 山本恭央・野見山 桂・水川葉月・滝口満喜・石塚真由美・国末達也・田辺 信介
  • Organizer: 環境ホルモン学会第18回研究発表会
  • Place of Presentation: 栃木県下野市 自治医科大学
  • Year and Date: 2015-12-10
• [Presentation] Lipid composition in the brain compartments of striped dolphins (Stenella coeruleoalba) in relation to the accumulation of environmental pollutants (PCBs and OH-PCBs) (2015)
  • Author(s): Mari Ochiai, Kei Nomiyama, Tomohiko Isobe, Tadasu K. Yamada, Yuko Tajima, Hisato Iwata, Masao Amano, Shinsuke Tanabe
  • Organizer: 21st Biennial Society for Marine Mammalogy Conference on the Biology of Marine Mammal
  • Place of Presentation: San Francisco, California, USA
  • Year and Date: 2015-11-14
  • Int'l Joint Research
• [Presentation] Omics approach of proteomic and metabolomic analysis for PCBs toxicity in the dog brain (2015)
  • Author(s): Kohki Takaguchi, Kei Nomiyama, Maria C. Lauan, Jean Yoo, Hazuki Mizukawa, Hisato Iwata, Tatsuya Kunisue, Shinsuke Tanabe
  • Organizer: Society of Environmental Toxicology and Chemistry (SETAC) North America 36th Annual Meeting
  • Place of Presentation: Salt Lake City, Utah, USA
  • Year and Date: 2015-11-01
  • Int'l Joint Research
• [Presentation] Toxicological assessment of polychlorinated biphenyls (PCBs) and hydroxylated PCBs (OH-PCBs) in the brain of dogs using metabolomics approach (2015)
  • Author(s): Kei Nomiyama, Akifumi Eguchi, Hazuki Mizukawa, Jean Yoo, Kohki Takaguchi, Yasuo Yamamoto, Tomoko Oshihoi, Hisato Iwata, Tatsuya Kunisue, Shisuke Tanabe
  • Organizer: Society of Environmental Toxicology and Chemistry (SETAC) North America 36th Annual Meeting
  • Place of Presentation: Salt Lake City, Utah, USA
  • Year and Date: 2015-11-01
  • Int'l Joint Research
• [Presentation] Metabolism and biotransformation of organohalogen compounds in the liver microsomes of cats and dogs. (2015)
  • Author(s): Hazuki Mizukawa, Kei Nomiyama, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M. Nakayama, Misaki Maehara, Shisuke Tanabe Mayumi Ishizuka
  • Organizer: Society of Environmental Toxicology and Chemistry (SETAC) North America 36th Annual Meeting
  • Place of Presentation: Salt Lake City, Utah, USA
  • Year and Date: 2015-11-01
  • Int'l Joint Research
• [Presentation] Contamination status of organohalogen compounds and their hydroxylated metabolites in pet cats: Effects on thyroid hormones homeostasis (2015)
  • Author(s): Yasuo Yamamoto, Kei Nomiyama, Hazuki Mizukawa, Kohki Takiguchi, Mayumi Ishizuka, Tatsuya Kunisue, Shinsuke Tanabe
  • Organizer: Society of Environmental Toxicology and Chemistry (SETAC) North America 36th Annual Meeting
  • Place of Presentation: Salt Lake City, Utah, USA
  • Year and Date: 2015-11-01
  • Int'l Joint Research
• [Presentation] 鹿児島県南さつま市にマスストランディングしたスジイルカ (Stenella coeruleoalba) の脳内脂質組成とハロゲン化代謝物濃度 (2015)
  • Author(s): 落合真理・野見山 桂・磯部友彦・山田 格・田島木綿子・天野雅男・田辺信介
  • Organizer: 日本セトロジー研究会第26回（あきた白神）大会
  • Place of Presentation: 秋田県山本郡八峰町 あきた白神体験センター
  • Year and Date: 2015-07-18
• [Presentation] 第II 相抱合反応の種差：食肉目におけるグルクロン酸抱合酵素の進化と遺伝子構造 (2015)
  • Author(s): 池中良徳・筧 麻友・中山翔太・川合佑典・渡邊研右・水川葉月・野見山 桂・田辺信介・石塚真由美
  • Organizer: 第24回環境化学討論会
  • Place of Presentation: 北海道札幌市札幌コンベンションセンター
  • Year and Date: 2015-06-24
• [Presentation] メタボローム解析によるイヌ脳中PCBs, OH-PCBs の毒性影響評価 (2015)
  • Author(s): 野見山桂・江口哲史・水川葉月・Jean Yoo・高口倖暉・山本泰央・忍穂井智子・岩田久人・国末達也・田辺信介
  • Organizer: 第24回環境化学討論会
  • Place of Presentation: 北海道札幌市札幌コンベンションセンター
  • Year and Date: 2015-06-24
• [Presentation] ポリ塩化ビフェニル（PCBs）を曝露したイヌの脳プロテオーム解析による毒性影響評価 (2015)
  • Author(s): 高口倖暉・野見山 桂・Claret Lauan Maria・草木桃子・Jean Yoo・水川葉月・岩田久人・国末達也・田辺信介
  • Organizer: 第24回環境化学討論会
  • Place of Presentation: 北海道札幌市札幌コンベンションセンター
  • Year and Date: 2015-06-24
• [Presentation] ペットネコにおける有機ハロゲン化合物および水酸化代謝物の汚染実態と甲状腺ホルモン恒常性への影響 (2015)
  • Author(s): 山本恭央・野見山 桂・水川葉月・滝口満喜・石塚真由美・国末達也・田辺信介
  • Organizer: 第24回環境化学討論会
  • Place of Presentation: 北海道札幌市札幌コンベンションセンター
  • Year and Date: 2015-06-24
• [Presentation] バイカルアザラシ (Pusa sibirica) における水酸化PCBsの毒性影響評価 (2014)
  • Author(s): 野見山桂・平川周作・江口哲史・今枝大輔・Jean, Y.・国末達也・岩田久人・田辺信介
  • Organizer: 環境ホルモン学会第17回研究発表会
  • Place of Presentation: 東京大学山上会館
  • Year and Date: 2014-12-09 – 2014-12-10
• [Presentation] ニホンザルにおける水酸化PCBsの蓄積特性：胎盤を介した胎児への移行 (2014)
  • Author(s): 辻沢雄将・野見山桂・谷地森秀二・葦田恵美子・田辺信介
  • Organizer: 環境ホルモン学会第17回研究発表会
  • Place of Presentation: 東京大学山上会館
  • Year and Date: 2014-12-09 – 2014-12-10
• [Presentation] Toxicological assessment of polychlorinated biphenyls (PCBs) and their metabolites (OH-PCBs) in the liver of wild Baikal seals (Pusa sibirica): Application of microarray and biochemical analysis. (2014)
  • Author(s): Nomiyama, K., Hirakawa, S., Eguchi, A., Kanbara, C., Imaeda, D., Jean, U., Kunisue, T., Kim, E. Y., Iwata, H. and Tanabe, S.
  • Organizer: International Conference of Asian Environmental Chemistry 2014 (ICAEC2014)
  • Place of Presentation: Chulabhorn Research Institute, Bangkok, Thailand
  • Year and Date: 2014-11-24 – 2014-11-26
• [Presentation] PCBs, PBDEs and their hydroxylated metabolites in the brain of free-ranging toothed and baleen whales. (2014)
  • Author(s): Ochiai, M., Nomiyama, K., Isobe, T., Yamada, T. K., Tajima, Y., Makara, M., Amano, M., Matsuishi, T., Iwata, H. and Tanabe, S.
  • Organizer: 6th Bilateral Seminar Italy; Japan on Physical and Chemical Impacts on Marine Organisms: Supporting Blue Growth in Meaningful Mutual Symbiosis with the Marine Environment
  • Place of Presentation: CNR, Palermo, Italy
  • Year and Date: 2014-11-19 – 2014-11-20
  • Invited
• [Presentation] Interspecies differences of PBDEs metabolic capacity and excretion in the dog and cat. (2014)
  • Author(s): Nomiyama, K., Mizukawa, H., Nakatsu, A., Takaguchi, K. and Tanabe, S.
  • Organizer: SETAC North America 35th Annual Meeting
  • Place of Presentation: Vancouver Convention Centre, Vancouver, British Columbia, Canada
  • Year and Date: 2014-11-09 – 2014-11-13
• [Presentation] ハクジラ・ヒゲクジラ類の脳に残留する有機ハロゲン代謝物 (2014)
  • Author(s): 落合真理・野見山 桂・磯部友彦・山田 格・田島木綿子・真柄真実・天野雅男・松石 隆・田辺信介
  • Organizer: 日本セトロジー研究会第25回（松山）大会
  • Place of Presentation: 愛媛大学, 松山市
  • Year and Date: 2014-05-24 – 2014-05-25
• [Presentation] GC-ECNI/MS による脳・肝臓中水酸化 PCBs の一斉分析法開発 (2014)
  • Author(s): 江口哲史・野見山桂・落合真理・水川葉月・長野靖子・神原千佳・中川勝博・田中幸樹・宮川治彦・田辺信介
  • Organizer: 第23回環境化学討論会
  • Place of Presentation: 京都大学, 京都市
  • Year and Date: 2014-05-14 – 2014-05-16
• [Presentation] イヌ・ネコにおけるPCBs および水酸化代謝物の脳移行 (2014)
  • Author(s): 高口倖暉・野見山桂・長野靖子・水川葉月・落合真理・中津 賞・田辺信介
  • Organizer: 第23回環境化学討論会
  • Place of Presentation: 京都大学, 京都市
  • Year and Date: 2014-05-14 – 2014-05-16
• [Presentation] イヌ・ネコに残留するPCBs の代謝・排泄能とその種間比較 (2014)
  • Author(s): 野見山桂・長野靖子・水川葉月・中津 賞・田辺信介
  • Organizer: 第23回環境化学討論会
  • Place of Presentation: 京都大学, 京都市
  • Year and Date: 2014-05-14 – 2014-05-16
• [Presentation] ニホンザルにおける水酸化PCBsの蓄積特性：胎盤を介した胎児への移行 (2014)
  • Author(s): 辻沢雄将・野見山桂・谷地森秀二・葦田恵美子・田辺信介
  • Organizer: 第23回環境化学討論会
  • Place of Presentation: 京都大学, 京都市
  • Year and Date: 2014-05-14 – 2014-05-16
• [Presentation] ネコ科動物における有機ハロゲン化合物の代謝能解析 (2014)
  • Author(s): 水川葉月・池中良徳・野見山桂・田辺信介・宇根有美・伊藤真輝・高江洲昇・長野靖子・中山翔太・石塚真由美
  • Organizer: 第23回環境化学討論会
  • Place of Presentation: 京都大学, 京都市
  • Year and Date: 2014-05-14 – 2014-05-16
• [Presentation] ペットネコにおける有機ハロゲン化合物および水酸化代謝物の汚染実態と曝露源の推定 (2014)
  • Author(s): 山本恭央・野見山桂・水川葉月・長野靖子・田辺信介
  • Organizer: 第23回環境化学討論会
  • Place of Presentation: 京都大学, 京都市
  • Year and Date: 2014-05-14 – 2014-05-16
• [Presentation] ヒゲクジラ・ハクジラ類におけるOH-PCBs およびOH-PBDEs の蓄積特性と脳移行 (2014)
  • Author(s): 落合真理・野見山 桂・磯部友彦・山田 格・田島木綿子・真柄真実・天野雅男・松石 隆・田辺信介
  • Organizer: 第23回環境化学討論会
  • Place of Presentation: 京都大学, 京都市
  • Year and Date: 2014-05-14 – 2014-05-16
• [Presentation] Tissue-specific concentrations of polar pharmaceuticals and personal care products (PPCPs) in wild fish from wastewater discharge area. (2014)
  • Author(s): Tanoue, R., Nomiyama, K., Isobe, T., Shinohara, R. and Tanabe, S.
  • Organizer: SETAC Europe 24th Annual Meeting
  • Place of Presentation: Congress Center Basel, Switzerland
  • Year and Date: 2014-05-11 – 2014-05-15
• [Presentation] Chronic exposures of persistent organic pollutants (POPs) and their hydroxylated metabolites in the brain of free-ranging toothed and baleen whales. (2014)
  • Author(s): Ochiai, M., Nomiyama, K., Isobe, T., Yamada, T. K., Tajima, Y., Makara, M., Amano, M. and Tanabe, S.
  • Organizer: SETAC Europe 24th Annual Meeting
  • Place of Presentation: Congress Center Basel, Switzerland
  • Year and Date: 2014-05-11 – 2014-05-15
• [Presentation] Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBs) in the Baikal seals and implication from a toxicogenomic approach. (2013)
  • Author(s): K. Nomiyama
  • Organizer: The 33rd International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2013)
  • Place of Presentation: Daegu, Korea
• [Presentation] Contamination status of polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in the brain of finless porpoises (Neophocaena phocaenoides) (2013)
  • Author(s): M. Ochiai
  • Organizer: 20th Biennial Conference on the Biology of Marine Mammals.
  • Place of Presentation: Dunedin, New Zealand
• [Presentation] スナメリ (Neophocaena phocaenoides) に残留する有機ハロゲン化合物の代謝と脳移行 (2013)
  • Author(s): 落合真理
  • Organizer: 第24回日本セトロジー研究会
  • Place of Presentation: 富山市科学博物館
• [Presentation] 日本沿岸に生息する小型歯鯨類のOH-PCBsおよびOH-PBDEs: 脳移行と脳内分布 (2013)
  • Author(s): 落合真理
  • Organizer: 第22回環境化学討論会
  • Place of Presentation: 東京農工大学府中キャンパス
• [Presentation] トキシコゲノミクス的アプローチによるバイカルアザラシ肝臓中水酸化PCBsの生体影響評価 (2013)
  • Author(s): 野見山 桂
  • Organizer: 第22回環境化学討論会
  • Place of Presentation: 東京農工大学府中キャンパス
• [Presentation] イヌ・ネコ肝臓におけるPCBs代謝物(OH-PCBs、Me-SO2-PCBs)の蓄積特性と代謝能の種間比較 (2013)
  • Author(s): 長野靖子
  • Organizer: 第22回環境化学討論会
  • Place of Presentation: 東京農工大学府中キャンパス
• [Presentation] Simultaneous determination of hydroxylated polychlorinated biphenyls in the liver and brain using gas chromatography/mass spectrometry (2013)
  • Author(s): A. Eguchi
  • Organizer: Society of Environmental Toxicology and Chemistry (SETAC) North America 34th Annual Meeting
  • Place of Presentation: Nashville. Tennessee, USA
• [Book] シャチ生態ビジュアル百科 (シャチの体にたまる有害化学物質) (2014)
  • Author(s): 野見山桂･田辺信介 水口博也(編)
  • Total Pages: 8
  • Publisher: 誠文堂新光社
• [Remarks] 研究トピックス
  • URL: https://www.ehime-u.ac.jp/post-1439/
• [Remarks] ニホンザルにおける水酸化PCBsの蓄積特性:胎盤を介した胎児への移行
  • URL: https://www.ehime-u.ac.jp/data_study/data_study-5935/
• [Remarks] ACS Newsに注目論文として掲載
  • URL: http://www.acs.org/content/acs/en/pressroom/presspacs/2016/acs-presspac-january-6-2016/fish-flavored-cat-food-could-contribue-to-feline-hyperthyroidism.html