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Brain-derived neurotrophic factor as predictor of depression, and dietary and nutritional factors in a Japanese working population

Research Project

Project/Area Number 25702006
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Eating habits
Research InstitutionNational Center for Global Health and Medicine

Principal Investigator

NANRI Akiko  国立研究開発法人国立国際医療研究センター, 疫学・予防研究科, 室長 (80523646)

Research Collaborator MIZOUE Tetsuya  国立国際医療研究センター, 疫学・予防研究科, 科長
MIKI Takako  国立国際医療研究センター, 疫学・予防研究科, 研究員
KUROTANI Kayo  国立国際医療研究センター, 疫学・予防研究科, 上級研究員
KUWAHARA Keisuke  帝京大学, 公衆衛生大学院, 助教
Akter Shamima  国立国際医療研究センター, 疫学・予防研究科, 研究員
KASHINO Ikuko  国立国際医療研究センター, 疫学・予防研究科, 研究員
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2013: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywordsうつ / BDNF / 葉酸 / ビタミンD / 食事パターン / 職域 / 栄養疫学 / 食事
Outline of Final Research Achievements

This study was aimed to examine the association of dietary and nutritional factors and dietary patterns with serum brain-derived neurotrophic factor (BDNF) among 2162 men and women who participated in a health survey. Participants were asked to fill out two types of survey questionnaire (for diet and for overall health-related lifestyle) and to donate venous blood.
Serum concentrations of folate and 25-hydroxyvitamin D and dietary intakes of docosahexaenoic acid and eicosapentaenoic acid were not associated with serum BDNF concentrations. For dietary pattern analysis, a healthy dietary pattern characterized by high intakes of vegetables, fruits, mushrooms, potatoes, seaweeds, soy products was associated with lower concentrations of BDNF.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (14 results)

All 2017 2016 2015 2014 2013

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Acknowledgement Compliant: 8 results) Presentation (3 results)

  • [Journal Article] Serum 25-hydroxyvitamin D and metabolic syndrome in a Japanese working population: The Furukawa Nutrition and Health Study2017

    • Author(s)
      Akter S, Eguchi M, Kurotani K, Kochi T, Kashino I, Ito R, Kuwahara K, Tsuruoka H, Kabe I, Mizoue T
    • Journal Title

      Nutrition

      Volume: 36 Pages: 26-32

    • DOI

      10.1016/j.nut.2016.02.024

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dietary fiber intake and depressive symptoms in Japanese employees: The Furukawa Nutrition and Health Study2016

    • Author(s)
      Miki T, Eguchi M, Kurotani K, Kochi T, Kuwahara K, Ito R, Kimura Y, Tsuruoka H, Akter S, Kashino I, Kabe I, Kawakami N, Mizoue T
    • Journal Title

      Nutrition

      Volume: 32 Issue: 5 Pages: 584-589

    • DOI

      10.1016/j.nut.2015.11.014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] High dietary acid load is associated with insulin resistance: The Furukawa Nutrition and Health Study2016

    • Author(s)
      Akter S, Eguchi M, Kuwahara K, Kochi T, Ito R, Kurotani K, Tsuruoka H, Nanri A, Kabe I, Mizoue T
    • Journal Title

      Clinical Nutrition

      Volume: 35 Issue: 2 Pages: 453-459

    • DOI

      10.1016/j.clnu.2015.03.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dietary patterns derived by reduced rank regression (RRR) and depressive symptoms in Japanese employees: The Furukawa nutrition and health study2015

    • Author(s)
      Miki T, Kochi T, Kuwahara K, Eguchi M, Kurotani K, Tsuruoka H, Ito R, Kabe I, Kawakami N, Mizoue T, Nanri A
    • Journal Title

      Psychiatry Resarch

      Volume: 229 Issue: 1-2 Pages: 214-219

    • DOI

      10.1016/j.psychres.2015.07.033

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] High dietary acid load is associated with increased prevalence of hypertension: the Furukawa Nutrition and Health Study2015

    • Author(s)
      Akter S, Eguchi M, Kurotani K, Kochi T, Pham NM, Ito R, Kuwahara K, Tsuruoka H, Mizoue T, Kabe I, Nanri A
    • Journal Title

      Nutrition

      Volume: 31 Issue: 2 Pages: 298-303

    • DOI

      10.1016/j.nut.2014.07.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dietary patterns and sleep symptoms in Japanese workers: the Furukawa Nutrition and Health Study2015

    • Author(s)
      Kurotani K, Kochi T, Nanri A, Eguchi M, Kuwahara K, Tsuruoka H, Akter S, Ito R, Pham NM, Kabe I, Mizoue T
    • Journal Title

      Sleep Med

      Volume: 16 Issue: 2 Pages: 298-304

    • DOI

      10.1016/j.sleep.2014.09.017

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Low serum 25-hydroxyvitamin D concentrations are associated with increased likelihood of having depressive symptoms among Japanese workers2015

    • Author(s)
      Mizoue T, Kochi T, Akter S, Eguchi M, Kurotani K, Tsuruoka H, Kuwahara K, Ito R, Kabe I, Nanri A
    • Journal Title

      J Nutr

      Volume: 145 Issue: 3 Pages: 541-546

    • DOI

      10.3945/jn.114.204115

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary intake of minerals in relation to depressive symptoms in Japanese employees: The Furukawa Nutrition and Health Study2015

    • Author(s)
      Miki T, Kochi T, Eguchi M, Kuwahara K, Tsuruoka H, Kurotani K, Ito R, Akter S, Kashino I, Pham NM, Kabe I, Kawakami N, Mizoue T, Nanri A
    • Journal Title

      Nutrition

      Volume: 31 Issue: 5 Pages: 686-690

    • DOI

      10.1016/j.nut.2014.11.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Macronutrient intake and depressive symptoms among Japanese male workers: the Furukawa Nutrition and Health Study2014

    • Author(s)
      Nanri A, Eguchi M, Kuwahara K, Kochi T, Kurotani K, Ito R, Pham NM, Tsuruoka H, Akter S, Jacka F, Mizoue T, Kabe I
    • Journal Title

      Psychiatry Res

      Volume: 220 Issue: 1-2 Pages: 263-268

    • DOI

      10.1016/j.psychres.2014.08.026

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Flushing response modifies the association of alcohol consumption with markers of glucose metabolism in Japanese men and women.2014

    • Author(s)
      Kuwahara K, Kochi T, Nanri A, Tsuruoka H, Kurotani K, Pham NM, Akter S, Kabe I, Mizoue T.
    • Journal Title

      Alcohol Clin Exp Res.

      Volume: 38 Issue: 4 Pages: 1042-1048

    • DOI

      10.1111/acer.12323

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plant oils were associated with low prevalence of impaired glucose metabolism in Japanese workers.2013

    • Author(s)
      Kurotani K, Kochi T, Nanri A, Tsuruoka H, Kuwahara K, Pham NM, Kabe I, Mizoue T.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 5 Pages: e64758-e64758

    • DOI

      10.1371/journal.pone.0064758

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 食事要因と抑うつに関する職域疫学研究2014

    • Author(s)
      南里明子、溝上哲也
    • Organizer
      第110回日本精神神経学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 未定(職域における食のポピュレーションアプローチ)2014

    • Author(s)
      南里明子
    • Organizer
      健康管理研究協議会 第52回総会
    • Place of Presentation
      東京工科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 栄養素および食事パターンと抑うつ症状に関する職域疫学研究2014

    • Author(s)
      南里明子、溝上哲也
    • Organizer
      第36回日本生物学的精神医学会 第57回日本神経化学会
    • Place of Presentation
      奈良県文化会館
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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