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Principle for development of stress-responsive self-strengthened metallic implants on the basis of unique mechanical function of bone

Research Project

Project/Area Number 25702027
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKindai University (2016)
Tohoku University (2013-2015)

Principal Investigator

NAKAI Masaaki  近畿大学, 理工学部, 准教授 (20431603)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords生体材料 / チタン合金 / 変形誘起相変態 / オメガ相 / 疲労特性 / 脊椎固定 / 曲げ変形 / 生体用金属材料 / 弾性率 / 力学的特性
Outline of Final Research Achievements

In the metals with self-tunable elastic modulus developed by our group, the elastic modulus and strength are increased by deformation-induced phase transformation. Using this function, we have started to try a development of stress-responsive self-strengthened metallic implants. Spinal fixation devices seem to be one of the applications for such the metals, and thus their responses to bending deformations were investigated in this study. As the results, the deformation-induced ω phase was observed in both the compression and tension sides of the bended rods. The metals with self-tunable elastic modulus exhibited high fatigue strengths under tension-tension modes so that high durability could be obtained by suitable surface strengthening treatments for suppressing fretting fatigue at the contacts between the components in spinal fixation devices during cyclic bending deformations.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (89 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (22 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 22 results,  Open Access: 7 results,  Acknowledgement Compliant: 9 results) Presentation (65 results) (of which Int'l Joint Research: 1 results,  Invited: 22 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Abnormal Deformation Behavior of Oxygen-added Beta-type Ti-29Nb-13Ta-4.6Zr Alloys for Biomedical Applications2017

    • Author(s)
      H. Liu, M. Niinomi, M. Nakai, X. Cong, K. Cho, C. J. Boehlert, and V. Khademi.
    • Journal Title

      Met. Mater. Trans. A

      Volume: 48 Issue: 1 Pages: 139-149

    • DOI

      10.1007/s11661-016-3836-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Athermal and Deformation-induced β-phase Transformations in Biomedical Beta-type Alloy Ti-9Cr-0.2O2016

    • Author(s)
      H. Liu, M.Niinomi, M. Nakai
    • Journal Title

      Acta Materialia

      Volume: 106 Pages: 162-170

    • DOI

      10.1016/j.actamat.2016.01.008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Using cavitation peening to improve the fatigue life of titanium alloy Ti-6Al-4V components manufactured by electron beam melting2016

    • Author(s)
      M. Sato, O. Takakuwa, M. Nakai, M. Niinomi, F. Takeo and H. Soyama
    • Journal Title

      Mater. Sci. Appl.

      Volume: 7 Issue: 04 Pages: 181-191

    • DOI

      10.4236/msa.2016.74018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhancing the durability of spinal implant fixture applications made of Ti-6Al-4V ELI by means of cavitation peening2016

    • Author(s)
      O. Takakuwa, M. Nakai, K. Narita, M. Niinomi, K. Hasegawa and H. Soyama
    • Journal Title

      Int. J. Fatigue

      Volume: 92 Pages: 360-367

    • DOI

      10.1016/j.ijfatigue.2016.07.021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Change in Mechanical Properties of Biomechanical Ti-12Cr Subjected to Heat Treatment and Surface Modification Processing2016

    • Author(s)
      丹羽謙太郎, 赤堀俊和, 新家光雄, 服部友一, 仲井正昭
    • Journal Title

      Journal of the Japan Institute of Metals and Materials

      Volume: 80 Issue: 12 Pages: 764-771

    • DOI

      10.2320/jinstmet.J2016036

    • NAID

      130005284306

    • ISSN
      0021-4876, 1880-6880, 2433-7501
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Solute Oxygen on Compressive Fatigue Strength of Spinal Fixation Rods Made of Ti–29Nb–13Ta–4.6Zr Alloys2016

    • Author(s)
      Y.-S. Lee, M. Niinomi, M. Nakai, K. Narita and H.H. Liu
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 57 Issue: 12 Pages: 1993-1997

    • DOI

      10.2320/matertrans.MI201504

    • NAID

      130005284458

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Current Situation and Challenges and Prospects of the Design and Manufacturing Process of the Spinal Implants2016

    • Author(s)
      織部一弥, 長谷川和宏, 北原恒, 田村貴志, 成田健吾, 山中茂, 仲井正昭, 高久田和夫, 新家光雄
    • Journal Title

      Materia Japan

      Volume: 55 Issue: 4 Pages: 142-146

    • DOI

      10.2320/materia.55.142

    • NAID

      130005140499

    • ISSN
      1340-2625, 1884-5843
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomedical Titanium Alloys with Young’s Moduli Close to That of Cortical Bone, Regenerative Biomaterials2016

    • Author(s)
      M. Niinomi, H. Li, M. Nakai, H. Liu and Y. Liu
    • Journal Title

      Regenerative Biomaterials

      Volume: - Issue: 3 Pages: 1-13

    • DOI

      10.1093/rb/rbw016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] β-type titanium alloys for spinal fixation surgery with high Young’s modulus variability and good mechanical properties2015

    • Author(s)
      Huihong Liu, Mitsuo Niinomi, Masaaki Nakai and Ken Cho
    • Journal Title

      Acta Biomaterialia

      Volume: 24 Pages: 361-369

    • DOI

      10.1016/j.actbio.2015.06.022

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Predominant factor determining wear properties of β-type and (α+β)-type titanium alloys in metal-to-metal contact for biomedical applications2015

    • Author(s)
      Y.-S. Lee, M. Niinomi, M. Nakai, K. Narita, J. Hieda and K. Cho
    • Journal Title

      J. Mech. Behav. Biomed. Mater.

      Volume: 41 Pages: 208-220

    • DOI

      10.1016/j.jmbbm.2014.10.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mechanical properties and cytocompatibility of oxygen-modified beta-type Ti-Cr alloys for spinal fixation devices2015

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, K. Cho, K. Narita, M. Sen, H. Shiku and T. Matsue
    • Journal Title

      Acta Biomater.

      Volume: 12 Pages: 352-361

    • DOI

      10.1016/j.actbio.2014.10.014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Differences in Wear Behaviors at Sliding Contacts for β-Type and (α + β)-Type Titanium Alloys in Ringer’s Solution and Air2015

    • Author(s)
      Y.-S. Lee, M. Niinomi, M. Nakai, K. Narita and K. Cho
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 56 Issue: 3 Pages: 317-326

    • DOI

      10.2320/matertrans.M2014365

    • NAID

      130004825261

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bending springback behavior related to deformation-induced phase transformations in Ti-12Cr and Ti-29Nb-13Ta4.6Zr alloys for spinal fixation applications2014

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, J. Hieda and K.Cho
    • Journal Title

      J. Mech. Behav. Biomed. Mater.

      Volume: 34 Pages: 66-74

    • DOI

      10.1016/j.jmbbm.2014.01.013

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Changeable Young's modulus with large elongation-to-failure in β-type titanium alloys for spinal fixation applications2014

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, J. Hieda and K.Cho
    • Journal Title

      Scripta Mater.

      Volume: 82 Pages: 29-32

    • DOI

      10.1016/j.scriptamat.2014.03.014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 金属材料と生体組織との力学的不整合とその対策2014

    • Author(s)
      仲井正昭, 新家光雄
    • Journal Title

      バイオマテリアル―生体材料―

      Volume: 32 Pages: 217-228

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of micro- and nano-scale wave-like structures on fatigue strength of a beta-type titanium alloy developed as a biomaterial2014

    • Author(s)
      K. Narita, M. Niinomi and M. Nakai
    • Journal Title

      J. Mech. Behav. Biomed. Mater.

      Volume: 29 Pages: 392-402

    • DOI

      10.1016/j.jmbbm.2013.09.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advances in development of titanium alloys for spinal fixation applications-Titanium alloys with high fatigue strength and low springback for spinal fixation applications-2014

    • Author(s)
      M. Niinomi, M. Nakai, J. Hieda, K. Cho and K. Narita
    • Journal Title

      Key Eng. Mater.

      Volume: 575-576 Pages: 446-452

    • DOI

      10.4028/www.scientific.net/kem.575-576.446

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimization of Cr and O contents in beta-type Ti-Cr-O alloys for obtaining both larger changeable Young's modulus during deformation and higher strength for use in spinal fixation applications2014

    • Author(s)
      M. Nakai, M. Niinomi, J. Hieda, K. Cho, K. Narita and H.H. Liu
    • Journal Title

      Proceedings of Materials Science and Technology Conference and Exhibition 2013

      Volume: - Pages: 2991-2997

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endurance of low-modulus β-type titanium alloys for spinal fixation2014

    • Author(s)
      M. Niinomi, M. Nakai, J. Hieda, K. Cho and K. Narita
    • Journal Title

      TMS2014 Annual Meeting Supplemental Proceedings

      Volume: - Pages: 205-212

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Difference of wear behavior between Ti-29Nb-13Ta-4.6Zr alloy and Ti-6Al-4V ELI alloy for biomedical applications2014

    • Author(s)
      M. Nakai, M. Niinomi, J. Hieda, K. Cho and Y.-S. Lee
    • Journal Title

      TMS2014 Annual Meeting Supplemental Proceedings

      Volume: - Pages: 217-220

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨-インプラント間の弾性率差による骨形態変化2013

    • Author(s)
      新家光雄, 服部友一, 仲井正昭
    • Journal Title

      日本骨形態計測学会雑誌

      Volume: 23 Pages: 23-30

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanical properties of Ti-12Cr alloy with self-tunable Young's modulus for use in spinal fixation devices2013

    • Author(s)
      M. Nakai, M. Niinomi, J. Hieda and K. Cho
    • Journal Title

      Proceedings of the 8th Pacific Rim International Congress on Advanced Materials and Processing

      Volume: - Pages: 1541-1546

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 生体内環境での使用を想定した新たな金属材料の開発2016

    • Author(s)
      仲井正昭
    • Organizer
      はりま産学交流会11月創造例会
    • Place of Presentation
      姫路商工会議所(兵庫県姫路市)
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 生体用準安定β型Ti-29Nb-13Ta-4.6Zr合金におけるω相の安定性に及ぼす酸素の特異な影響2016

    • Author(s)
      新家光雄, 赤堀俊和, 仲井正昭
    • Organizer
      日本金属学会2016年秋期(第159回)大会
    • Place of Presentation
      大阪大学(大阪府豊中市)
    • Year and Date
      2016-09-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生体用弾性率可変型チタン合金の化学組成と弾性率変化2016

    • Author(s)
      仲井正昭, 新家光雄
    • Organizer
      日本実験力学会 2016年度年次講演会
    • Place of Presentation
      近畿大学(大阪府東大阪市)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] High fatigue strength of Ti-12Cr rod as spinal fixation devices2016

    • Author(s)
      M. Nakai, M. Niinomi, H.H. Liu, K. Narita, O. Takakuwa and H. Soyama
    • Organizer
      THERMEC'2016
    • Place of Presentation
      Graz, Austria
    • Year and Date
      2016-05-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Beta-type titanium alloys for use as rods in spinal fixation devices2016

    • Author(s)
      M. Niinomi, M. Nakai, H.H. Liu and K. Narita
    • Organizer
      TMS2016 145th Annual Meeting & Exhibition
    • Place of Presentation
      Nashville, Tennessee (USA)
    • Year and Date
      2016-02-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 弾性率可変型チタン合金の開発2015

    • Author(s)
      仲井正昭, 新家光雄
    • Organizer
      第42回日本臨床バイオメカニクス学会
    • Place of Presentation
      ソラシティカンファレンスセンター(東京都千代田区)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 高耐久性弾性率可変型チタン合金製脊椎固定器具の開発2015

    • Author(s)
      仲井正昭, 新家光雄, 劉恢弘, 成田健吾, 祖山均, 髙桑脩
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規インプラント導入と添付文書策定の問題点2015

    • Author(s)
      織部一弥, 長谷川和宏, 成田健吾, 仲井正昭, 高久田和夫, 新家光雄
    • Organizer
      第24回日本脊椎インストゥルメンテーション学会
    • Place of Presentation
      りゅーとぴあ 新潟市民芸術文化会館(新潟県新潟市)
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 弾性率可変型Ti-12Cr合金の疲労特性2015

    • Author(s)
      仲井正昭, 新家光雄, 劉恢弘, 塚原真宏, 遠所茂夫, 三坂佳孝
    • Organizer
      日本金属学会2015年秋期(第157回)大会
    • Place of Presentation
      九州大学(福岡県福岡市)
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 熱処理および表面改質処理を施した生体用Ti-12Cr合金の力学的特性の変化2015

    • Author(s)
      丹羽謙太郎, 赤堀俊和, 新家光雄, 仲井正昭
    • Organizer
      日本金属学会2015年秋期(第157回)大会
    • Place of Presentation
      九州大学(福岡県福岡市)
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Change in mechanical strength of newly developed Ti-Cr system alloy subjected to heat treatment and surface modification processing2015

    • Author(s)
      K. Niwa, T. Akahori, T. Hattori, M. Niinomi and M. Nakai
    • Organizer
      27th European Conference on Biomaterials
    • Place of Presentation
      Krakow (Poland)
    • Year and Date
      2015-08-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of biomedical titanium alloys with a focus on controlling Young's modulus2015

    • Author(s)
      M. Niinomi, M. Nakai, H.H. Liu and K. Cho
    • Organizer
      The 13th World Conference on Titanium (Ti-2015)
    • Place of Presentation
      San Diego, California (USA)
    • Year and Date
      2015-08-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Development of spinal fixation device made of surface modified beta titanium alloys combined lower stiffness and higher mechanical safety for elderly patient2015

    • Author(s)
      K. Narita, M. Niinomi, M. Nakai, Suyalatu, H. Soyama and O. Takakuwa
    • Organizer
      The 13th World Conference on Titanium (Ti-2015)
    • Place of Presentation
      San Diego, California (USA)
    • Year and Date
      2015-08-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] A β-type titanium alloy with significantly changeable Young's modulus and good mechanical properties used for spinal fixation application2015

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, K. Cho and K. Narita
    • Organizer
      The 13th World Conference on Titanium (Ti-2015)
    • Place of Presentation
      San Diego, California (USA)
    • Year and Date
      2015-08-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新たな生体用チタン合金の開発と脊椎固定器具への応用2015

    • Author(s)
      仲井正昭
    • Organizer
      チタノミックス研究会平成27年度講演会
    • Place of Presentation
      豊橋商工会議所(愛知県豊橋市)
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Bending springback of biomedical beta-type titanium alloys for spinal fixation applications2015

    • Author(s)
      M. Nakai, M. Niinomi, K. Cho, H.H. Liu and K. Narita
    • Organizer
      Biomaterials International 2015
    • Place of Presentation
      Kenting (Taiwan)
    • Year and Date
      2015-06-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] β-type titanium alloy possessing remarkably changeable Young's modulus and good mechanical biocompatibility for spinal fixation surgery2015

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, K. Cho and K. Narita
    • Organizer
      第129回東北大学金属材料研究所講演会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脊椎固定器具用チタン合金の開発とその実用化に向けて2015

    • Author(s)
      仲井正昭, 新家光雄, 成田健吾
    • Organizer
      日本材料学会・疲労部門委員会および生体医療材料部門委員会合同公開委員会
    • Place of Presentation
      山形大学(山形県米沢市)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Optimization on chemical composition of Ti-Cr-O alloys for achieving significantly changeable Young's modulus and good mechanical properties for spinal fixation applications2015

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, K. Cho and K. Narita
    • Organizer
      軽金属学会第128回春期大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脊椎外科におけるインプラント治療と金属材料2015

    • Author(s)
      仲井正昭, 新家光雄, 成田健吾, 趙研, 劉恢弘
    • Organizer
      日本金属学会2015年春期(第156回)大会
    • Place of Presentation
      東京大学
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Remarkably changeable Young's modulus with good mechanical biocompatibility obtained in beta-type titanium alloys for spinal fixation applications2015

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, K. Cho and K. Narita
    • Organizer
      日本金属学会2015年春期(第156回)大会
    • Place of Presentation
      東京大学
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脊椎疾患の治療に用いられるインプラント材料の開発2015

    • Author(s)
      仲井正昭, 新家光雄, 成田健吾, 趙研, 劉恢弘
    • Organizer
      日本材料学会第38回生体・医療材料部門委員会
    • Place of Presentation
      東北大学
    • Year and Date
      2015-01-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 固溶酸素を利用した生体用β型Ti-Cr合金の機能改善2015

    • Author(s)
      仲井正昭, 新家光雄, 趙研, 劉恢弘
    • Organizer
      日本金属学会チタン製造プロセスと材料機能研究会第1回講演会
    • Place of Presentation
      関西大学
    • Year and Date
      2015-01-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 低弾性率チタン合金を用いた脊椎固定器具の開発に向けて2015

    • Author(s)
      成田健吾, 新家光雄, 仲井正昭, 蘇亜拉図, 高久田和夫, 長谷川和宏
    • Organizer
      特異構造金属・無機融合高機能材料開発共同研究プロジェクト平成26年度生体・医療材料開発分野分科会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2015-01-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] A novel β-type titanium alloy with changeable Young's modulus and large elongation-to-failure for spinal fixation devices2014

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, K. Cho and K. Narita
    • Organizer
      第13回日本金属学会東北支部研究発表大会
    • Place of Presentation
      岩手大学
    • Year and Date
      2014-12-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] A novel β-type titanium alloy with changeable Young's modulus and good ductility for spinal fixation devices2014

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, K. Cho and K. Narita
    • Organizer
      第128回東北大学金属材料研究所講演会
    • Place of Presentation
      東北大学
    • Year and Date
      2014-11-27 – 2014-11-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脊椎固定器具用チタン合金の微細組織と曲げ特性2014

    • Author(s)
      仲井正昭, 新家光雄, 成田健吾, 趙研, 劉恢弘
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2014-11-17 – 2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生体用β型チタン合金製脊椎固定器具の耐久性向上に及ぼすキャビテーションピーニングの効果2014

    • Author(s)
      仲井正昭, 新家光雄, 成田健吾, 趙研, 髙桑脩, 祖山均
    • Organizer
      軽金属学会第127回秋期大会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 医療用チタン合金の弾性率制御2014

    • Author(s)
      仲井正昭
    • Organizer
      日本金属学会・日本鉄鋼協会中国四国支部第120回金属物性研究会
    • Place of Presentation
      香川大学
    • Year and Date
      2014-10-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 低弾性率β型チタン合金の実用化に向けた取り組み2014

    • Author(s)
      仲井正昭、新家光雄、成田健吾、趙研
    • Organizer
      東北大学金属材料研究所ワークショップおよび日本バイオマテリアル学会東北地域講演会「産学官連携による金属系バイオマテリアルの研究開発の最前線」
    • Place of Presentation
      東北大学
    • Year and Date
      2014-10-06 – 2014-10-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] キャビテーションピーニング処理によるβ型チタン合金製脊椎固定器具の耐久性改善2014

    • Author(s)
      成田健吾, 新家光雄, 仲井正昭, 蘇亜拉図, 祖山均, 髙桑脩
    • Organizer
      日本金属学会2014年秋期(第155回)大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] キャビテーションピーニングを施したTi-29Nb-13Ta-4.6Zr合金製脊椎固定器具の耐久性2014

    • Author(s)
      仲井正昭, 新家光雄, 成田健吾, 趙研, 髙桑脩, 祖山均
    • Organizer
      日本金属学会2014年秋期(第155回)大会および日本鉄鋼協会第168回秋季講演大会(共同セッション)
    • Place of Presentation
      名古屋大学
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Changeable Young's modulus with good ductility achieved in a β-type titanium alloy for spinal fixation applications2014

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, K. Cho and K. Narita
    • Organizer
      日本金属学会2014年秋期(第155回)大会および日本鉄鋼協会第168回秋季講演大会(共同セッション)
    • Place of Presentation
      名古屋大学
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 表面硬化処理を施した生体用β型チタン合金製脊椎固定器具の圧縮疲労強度2014

    • Author(s)
      成田健吾, 新家光雄, 仲井正昭, 蘇亜拉図, 祖山均, 髙桑脩
    • Organizer
      日本機械学会2014年度年次大会
    • Place of Presentation
      東京電機大学
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Changeable Young's modulus with good ductility in a β-type Ti-Cr alloy used for spinal fixation devices2014

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, K. Cho and K. Narita
    • Organizer
      材料フェスタ in 仙台
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-07-28 – 2014-07-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of cavitation peening on mechanical properties of spinal rods prepared using titanium alloys2014

    • Author(s)
      M. Nakai, M. Niinomi, K. Narita, K. Cho, O. Takakuwa and H. Soyama
    • Organizer
      東北大学大学院工学研究科表面力学設計研究会
    • Place of Presentation
      東北大学
    • Year and Date
      2014-06-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Changeable Young's modulus with good ductility in β-type titanium alloys for spinal fixation devices2014

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, J. Hieda and K. Cho
    • Organizer
      第127回東北大学金属材料研究所講演会
    • Place of Presentation
      東北大学
    • Year and Date
      2014-05-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] キャビテーションピーニングによるTi-6Al-4V ELI合金製脊椎固定器具の耐久性向上2014

    • Author(s)
      髙桑脩, 仲井正昭, 成田健吾, 新家光雄, 祖山均
    • Organizer
      ショットピーニング技術協会平成26年度学術講演会
    • Place of Presentation
      明治大学
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cr添加によるβ型Ti-Nb-Ta-Zr合金の弾性率自己調整機能化2014

    • Author(s)
      仲井正昭, 新家光雄, 稗田純子, 趙研, 成田健吾, 李強
    • Organizer
      軽金属学会第126回春期大会
    • Place of Presentation
      広島大学
    • Year and Date
      2014-05-17 – 2014-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Wear properties of interfaces composed of combinations of two-type titanium alloys for biomedical applications2014

    • Author(s)
      M. Nakai, M. Niinomi, K. Narita, J. Hieda, K. Cho and Y.-S. Lee
    • Organizer
      The 5th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Endurance of low-modulus beta-type titanium alloys for spinal fixation rods2014

    • Author(s)
      M. Niinomi, M. Nakai, J. Hieda, K. Cho and K. Narita
    • Organizer
      TMS2014 143rd Annual Meeting & Exhibition
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Difference of wear behavior between Ti-29Nb-13Ta-4.6Zr alloy and Ti-6Al-4V ELI alloy for biomedical applications2014

    • Author(s)
      M. Nakai, M. Niinomi, J. Hieda, K. Cho and Y.-S. Lee
    • Organizer
      TMS2014 143rd Annual Meeting & Exhibition
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 金属材料の力学的生体機能化2014

    • Author(s)
      新家光雄, 仲井正昭
    • Organizer
      日本金属学会2014年春期(第154回)大会
    • Place of Presentation
      東京工業大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Ti-29Nb-13Ta-4.6Zr合金の弾性率自己調整機能化2014

    • Author(s)
      仲井正昭, 新家光雄, 稗田純子, 趙研, 成田健吾, 李強
    • Organizer
      日本金属学会2014年春期(第154回)大会
    • Place of Presentation
      東京工業大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Characterization of sliding friction-induced subsurface deformation of Ti-29Nb-13Ta-4.6Zr alloys for biomedical applications2014

    • Author(s)
      Y.-S. Lee, M. Niinomi, M. Nakai, K. Narita, J. Hieda and K. Cho
    • Organizer
      日本金属学会2014年春期(第154回)大会および日本鉄鋼協会第167回春季講演大会(共同セッション)
    • Place of Presentation
      東京工業大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] dvances in development of titanium alloys for spinal fixation applications2013

    • Author(s)
      M. Niinomi, M. Nakai, J. Hieda, K. Cho and K. Narita
    • Organizer
      2nd International Congress on Advanced Materials (AM2013)
    • Place of Presentation
      Zhenjiang, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Development of mechanically biocompatible titanium alloys for fabricating biomedical implants2013

    • Author(s)
      M. Niinomi, M. Nakai, J. Hieda and K. Cho
    • Organizer
      The 2nd International GIGAKU Conference in Nagaoka (IGCN2013)
    • Place of Presentation
      Nagaoka, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mechanical properties of Ti-12Cr alloy with self-tunable Young's modulus for use in spinal fixation devices2013

    • Author(s)
      M. Nakai, M. Niinomi, J. Hieda and K. Cho
    • Organizer
      The 8th Pacific Rim International Conference on Advanced Materials and Processing (PRICM 8)
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Severe subsurface deformation of TNTZ alloys under dry sliding wear condition2013

    • Author(s)
      Y.-S. Lee, M. Niinomi, M. Nakai, J. Hieda and K. Cho
    • Organizer
      8th International Workshop on Biomaterials in Biosis-Abiosis Intelligent Interface Science (Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2013)
    • Place of Presentation
      Sansa Tei, Miyagi, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Low modulus titanium alloys for fabricating rods for spinal fixation device2013

    • Author(s)
      M. Niinomi, M. Nakai, J. Hieda, K. Cho and K. Narita
    • Organizer
      XII Brazilian MRS Meeting
    • Place of Presentation
      Campos de Jordao, Brazil
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Development of Ti-Zr based alloys with changeable Young's modulus for spinal fixation applications2013

    • Author(s)
      M. Nakai, M. Niinomi, J. Hieda, K. Cho, K. Narita and X.L. Zhao
    • Organizer
      XII Brazilian MRS Meeting
    • Place of Presentation
      Campos de Jordao, Brazil
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optimization of Cr and O contents in beta-type Ti-Cr-O alloys for obtaining both larger changeable Young's modulus during deformation and higher strength for use in spinal fixation applications2013

    • Author(s)
      M. Nakai, M. Niinomi, J. Hieda, K. Cho, K. Narita and H.H. Liu
    • Organizer
      Materials Science & Technology 2013 Conference & Exhibition (MS&T'13)
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optimization of Mo content in beta-type Ti-Mo alloys for obtaining larger changeable Young's modulus during deformation for use in spinal fixation applications2013

    • Author(s)
      M. Nakai, M. Niinomi, J. Hieda, K. Cho, K. Narita and X.F. Zhao
    • Organizer
      THERMEC'2013
    • Place of Presentation
      Las Vegas, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Relationship between heterogeneous microstructure and fatigue strength of Ti-Nb-Ta-Zr alloy subjected to aging treatments for biomedical materials2013

    • Author(s)
      K. Narita, M. Niinomi and M. Nakai
    • Organizer
      THERMEC'2013
    • Place of Presentation
      Las Vegas, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Wear properties of Ti-6Al-4V ELI/TNTZ combination for spinal implants2013

    • Author(s)
      Y.-S. Lee, M. Niinomi, M. Nakai, J. Hieda and K. Cho
    • Organizer
      THERMEC'2013
    • Place of Presentation
      Las Vegas, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Enhancement of mechanical biocompatibility of titanium alloys for load bearing implant devices with relation to elastic modulus2013

    • Author(s)
      M. Niinomi, M. Nakai, J. Hieda and K. Cho
    • Organizer
      International Symposium on EcoTopia Science'13 (ISETS'13)
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Compressive fatigue property of spinal fixation device with implant rods made of a beta titanium alloy for biomedical applications2013

    • Author(s)
      K. Narita, M. Niinomi, M. Nakai and Suyalatu
    • Organizer
      Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI4)
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] 応力誘起ω相変態を利用した脊椎固定器具用チタン合金の機能化2013

    • Author(s)
      仲井正昭, 新家光雄, 成田健吾, 稗田純子, 趙研
    • Organizer
      粉体粉末冶金協会平成25年度春季大会(第111回講演大会)
    • Place of Presentation
      早稲田大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脊椎固定用Ti-12Cr合金ロッドの曲げ特性2013

    • Author(s)
      仲井正昭, 新家光雄, 成田健吾, 稗田純子, 趙研, 劉恢弘
    • Organizer
      日本金属学会2013年秋期(第153回)大会
    • Place of Presentation
      金沢大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 気中および疑似生体内環境中における生体用β型チタン合金製脊椎固定器具の圧縮疲労特性2013

    • Author(s)
      成田健吾, 新家光雄, 仲井正昭, 蘇亜拉図
    • Organizer
      日本金属学会2013年秋期(第153回)大会
    • Place of Presentation
      金沢大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Characterization of subsurface deformation during dry sliding wear of new titanium TNTZ for biomedical applications2013

    • Author(s)
      Y.-S. Lee, M. Niinomi, M. Nakai, J. Hieda and K. Cho
    • Organizer
      日本金属学会2013年秋期(第153回)大会
    • Place of Presentation
      金沢大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 弾性率自己調整Ti-Mo合金のミクロ組織と力学的特性2013

    • Author(s)
      仲井正昭, 新家光雄, 稗田純子, 趙研, 成田健吾, 趙幸鋒
    • Organizer
      軽金属学会第125回秋期大会
    • Place of Presentation
      横浜国立大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Wear behavior of Ti64/TNTZ combination under dry sliding conditions2013

    • Author(s)
      Y.-S. Lee, M. Niinomi, M. Nakai, J. Hieda and K. Cho
    • Organizer
      軽金属学会第125回秋期大会
    • Place of Presentation
      横浜国立大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 弾性率自己調整金属製脊椎固定ロッドの曲げ特性2013

    • Author(s)
      仲井正昭, 新家光雄, 成田健吾, 稗田純子, 趙研, 劉恢弘
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2013 Annual Research Report
  • [Presentation] 次世代医療用チタン合金の開発と脊椎固定器具への応用

    • Author(s)
      仲井正昭, 成田健吾, 新家光雄
    • Organizer
      第1回東北大学メディカルサイエンス・シンポジウム
    • Place of Presentation
      ホテルメトロポリタン仙台
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] β型強化チタン合金、β型強化チタン合金の製造方法2015

    • Inventor(s)
      塚原真宏, 遠所茂夫, 三坂佳孝, 仲井正昭, 他2名
    • Industrial Property Rights Holder
      高周波熱錬株式会社, 国立大学法人東北大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-155089
    • Filing Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 脊椎固定用チタン合金製ロッド及びその製造方法2015

    • Inventor(s)
      新家光雄, 仲井正昭, 成田健吾, 祖山均, 髙桑脩
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-014462
    • Filing Date
      2015-01-28
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-21   Modified: 2020-01-20  

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