Designof clickable smart polymers for enrichment of biomarkers
| Project/Area Number |
25702029
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
Mitsuhiro Ebara 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA准主任研究者 (10452393)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | スマートポリマー / バイオマーカー / 早期診断 / 温度応答性 / 感染症 |
|---|
| Outline of Final Research Achievements |
We have developed a series of nano-sized temperature-responsive polymer-protein conjugates that separate and enrich analytes from solution and enable detection. Because smart conjugates bind analytes in solution prior to separation, conjugate-analytes binding avoids steric and mass transport limitations associated with surface-based techniques. Thus, the “smart” polymer-based diagnostic systems could enrich dilute salivary samples, overcoming the problem of low power supply in the developing world while retaining the advantages of a rapid and reversible capture and concentration abilities.
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Report
(4 results)
Research Products
(47 results)
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[Book] Polymer Journal2016
Author(s)
Katsuhiko Ariga, Kosuke Minami, Mitsuhiro Ebara, and Jun Nakanishi
Total Pages
19
Publisher
What Are Emerging Concepts and Challenges in NANO?: Nanoarchitectonics, Hand-Operating Nanotechnology, and Mechanobiology
Related Report
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