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Designof clickable smart polymers for enrichment of biomarkers

Research Project

Project/Area Number 25702029
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNational Institute for Materials Science

Principal Investigator

Mitsuhiro Ebara  国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA准主任研究者 (10452393)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Keywordsスマートポリマー / バイオマーカー / 早期診断 / 温度応答性 / 感染症
Outline of Final Research Achievements

We have developed a series of nano-sized temperature-responsive polymer-protein conjugates that separate and enrich analytes from solution and enable detection. Because smart conjugates bind analytes in solution prior to separation, conjugate-analytes binding avoids steric and mass transport limitations associated with surface-based techniques. Thus, the “smart” polymer-based diagnostic systems could enrich dilute salivary samples, overcoming the problem of low power supply in the developing world while retaining the advantages of a rapid and reversible capture and concentration abilities.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (47 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (4 results) Journal Article (18 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 18 results,  Acknowledgement Compliant: 5 results,  Open Access: 7 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (12 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results)

  • [Int'l Joint Research] University of Washington(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Chonnam National University(韓国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Washington(米国)

    • Related Report
      2014 Annual Research Report
  • [Int'l Joint Research] CHonnam National University(韓国)

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Fluidity of biodegradable substrate regulates carcinoma cell2016

    • Author(s)
      Sharmy S. Mano, Koichiro Uto, Takao Aoyagia and Mitsuhiro Ebara
    • Journal Title

      AIMS Materials Science

      Volume: 3 Issue: 1 Pages: 66-81

    • DOI

      10.3934/matersci.2016.1.66

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Biomimetic Approach to Hormone Resistant Prostate Cancer Cell Isolation Using Inactivated Sendai Virus (HVJ-E)2016

    • Author(s)
      Takaharu Okada, Koichiro Uto, Takao Aoyagi, Mitsuhiro Ebara
    • Journal Title

      Biomaterials Science

      Volume: 4 Issue: 1 Pages: 96-103

    • DOI

      10.1039/c5bm00375j

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Inactivated Sendai Virus (HVJ-E) Immobilized Electrospun Nanofiber for Cancer Therapy2016

    • Author(s)
      Takaharu Okada, Eri Niiyama, Koichiro Uto, Takao Aoyagi, Mitsuhiro Ebara
    • Journal Title

      Materials

      Volume: 9 Issue: 1 Pages: 12-12

    • DOI

      10.3390/ma9010012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] pH and Glucose Responsive Nanofibers for the Reversible Capture and Release of Lectins2015

    • Author(s)
      Yinan Wang, Yohei Kotsuchibashi, Koichiro Uto, Mitsuhiro Ebara, Takao Aoyagi, Yang Liu and Ravin Narain
    • Journal Title

      Biomaterials Science

      Volume: 3 Issue: 1 Pages: 152-162

    • DOI

      10.1039/c4bm00269e

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Temperature-responsive mixed core nanoparticle properties determined by the composition of statistical and block copolymers in the core2015

    • Author(s)
      Yohei Kotsuchibashi, Mitsuhiro Ebara, Allan S. Hoffman, Ravin Narain, Takao Aoyagi
    • Journal Title

      Polymer Chemistry

      Volume: 6 Issue: 10 Pages: 1693-1697

    • DOI

      10.1039/c4py01794c

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Spatio-Temporal Control of Boroxole-Sugar based Gels Structure via Photoinduced Proton Transfer2015

    • Author(s)
      Yohei Kotsuchibashi, Mitsuhiro Ebara, Takeshi Sato, Yinan Wang, Rajender Rajender, Dennis G. Hall, Ravin Narain, and Takao Aoyagi
    • Journal Title

      Journal of Physical Chemistry B

      Volume: 119 Issue: 6 Pages: 2323-2329

    • DOI

      10.1021/jp506478p

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Simultaneous Drug and Gene Delivery from The Biodegradable Poly(ε-caprolactone) Nanofibers for The Treatment of Liver Cancer2015

    • Author(s)
      Hui-Lian Che, Hwa Jeong Lee, Koichiro Uto, Mitsuhiro Ebara, Won Jong Kim, Takao Aoyagi, In-Kyu Park
    • Journal Title

      Journal of Nanoscience and Nanotechnology

      Volume: 15 Issue: 10 Pages: 7971-7975

    • DOI

      10.1166/jnn.2015.11233

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biodegradable Nanofiber for Delivery of Immunomodulating Agent in the Treatment of Basal Cell Carcinoma2015

    • Author(s)
      Richard Garrett, Eri Niiyama, Yohei Kotsuchibashi, Koichiro Uto, Mitsuhiro Ebara
    • Journal Title

      Fibers

      Volume: 3 Issue: 4 Pages: 478-490

    • DOI

      10.3390/fib3040478

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Design of Smart Nanogels that Respond to Physiologically Relevant pH Values and Temperatures2014

    • Author(s)
      Tomoyuki Omura, Mitsuhiro Ebara, James J. Lai, Xiangchun Yin, Allan S. Hoffman, and Patrick S. Stayton
    • Journal Title

      Journal of Nanoscience and Nanotechnology

      Volume: 14 Issue: 3 Pages: 2557-2562

    • DOI

      10.1166/jnn.2014.8551

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The taming of the cell : shape-memory nanopatterns direct cell orientation2014

    • Author(s)
      M . Ebara, K. Uto, N. Idota, T. Aoyagi
    • Journal Title

      International Journal of Nanomedicine

      Volume: 9 Pages: 117-126

    • DOI

      10.2147/ijn.s50677

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Temperature-responsive poly(e-caprolactone) cell culture platform with reversibly tunable nano-roughness and elasticity for control of myoblast morphology2014

    • Author(s)
      K . Uto, M . Ebara, T. Aoyagi
    • Journal Title

      International Journal of Molecular Science

      Volume: 15 Issue: 1 Pages: 1511-1524

    • DOI

      10.3390/ijms15011511

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Near-infrared Light-induced Remote Activation of Surface Shape-memory to Direct Cell Orientations2014

    • Author(s)
      Qinghui Shou, Koichiro Uto, Wei-Chih Lin, Takao Aoyagi, Mitsuhiro Ebara
    • Journal Title

      Macromolecular Chemistry and Physics

      Volume: 215 Issue: 24 Pages: 2473-2481

    • DOI

      10.1002/macp.201400353

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Simple Coating with pH-Responsive Polymer-Functionalized Silica Nanoparticles of Mixed Sizes for Controlled Surface Properties2013

    • Author(s)
      Yohei Kotsuchibashi, Yinan Wang, Young-Jin Kim, Mitsuhiro Ebara, Takao Aoyagi, Ravin Narain
    • Journal Title

      ACS Applied Materials & Interfaces

      Volume: 5 Issue: 20 Pages: 10004-10010

    • DOI

      10.1021/am403007f

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Smart Hyperthermia Nanofiber with Switchable Drug Release for Inducing Cancer Apoptosis2013

    • Author(s)
      Y.-J. Kim, M . Ebara, T. Aoyagi
    • Journal Title

      Advanced Functional Materials

      Volume: 23 Issue: 46 Pages: 5753-5761

    • DOI

      10.1002/adfm.201300746

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A photo-induced nanoparticle separation in microchannels via pH-sensitive surface traps2013

    • Author(s)
      M. Ebara, J. M. Hoffman, A. S. Hoffman, P. S. Stayton, J. J. Lai
    • Journal Title

      Langmuir

      Volume: 29 Issue: 18 Pages: 5388-5393

    • DOI

      10.1021/la400347r

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rewritable and shape-memory soft matter with dynamically tunable microchannel geometry in a biological temperature range2013

    • Author(s)
      M. Ebara, K. Uto, N. Idota, J. M. Hoffman, T. Aoyagi
    • Journal Title

      Soft Matter

      Volume: 9 Issue: 26 Pages: 3074-3080

    • DOI

      10.1039/c3cp50165e

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nano-decoration of Hemagglutinating Virus of Japan Envelope (HVJ-E) Using Layer-by-Layer Assembly Technique2013

    • Author(s)
      Takaharu Okada, Koichiro Uto, Masao Sasai, Chun Man Lee, Mitsuhiro Ebara, Takao Aoyagi
    • Journal Title

      Langmuir

      Volume: 29 Issue: 24 Pages: 7384-7392

    • DOI

      10.1021/la304572s

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of FITC-doped silica nanoparticles and study of their cellular uptake in the presence of lectins2013

    • Author(s)
      Yohei Kotsuchibashia, Yiyao Zhang, Marya Ahmed, Mitsuhiro Ebara, Takao Aoyagi, Ravin Narain
    • Journal Title

      Journal of Biomedical Materials Research: Part A

      Volume: 101A Issue: 7 Pages: 2090-2096

    • DOI

      10.1002/jbm.a.34498

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Apoptotic Cell Membrane-inspired Nanomaterials for Immunomodulation2016

    • Author(s)
      中川泰宏, 齋藤充弘, 青柳隆夫, 荏原充宏
    • Organizer
      MANA International Symposium 2016
    • Place of Presentation
      エポカルつくば,つくば市
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がんの温熱化学療法を実現可能なナノファイバーメッシュの開発2016

    • Author(s)
      新山瑛理, 小土橋陽平, 宇都甲一郎, 李千萬, 青柳隆夫, 荏原充宏
    • Organizer
      つくば医工連携フォーラム2016
    • Place of Presentation
      茨城県,つくば市
    • Year and Date
      2016-01-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 炎症治療へむけたアポトーシス細胞模倣インテリジェント高分子の開発2016

    • Author(s)
      中川泰宏, 齋藤充弘, 青柳隆夫, 荏原充宏
    • Organizer
      第25回インテリジェント材料・システムシンポジウム
    • Place of Presentation
      東京女子医科大学
    • Year and Date
      2016-01-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗炎症治療を目的としたホスファチジルセリン誘導体含有高分子の合成と評価2015

    • Author(s)
      中川泰宏, 齋藤充弘, 青柳隆夫, 荏原充宏
    • Organizer
      64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター,札幌
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 感染症バイオマーカーの濃縮・精製のためのクリック反応可能なスマートポリマーの設計2013

    • Author(s)
      吉武春佳, 宇都甲一郎, 荏原充宏, 青柳隆夫
    • Organizer
      第62回高分子年次大会
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] Smart ‘on-off’ switchable surfaces with carbohydrate residues for selective adhesion and collection of cells2013

    • Author(s)
      Mitsuhiro EBARA
    • Organizer
      246th ACS National Meeting & Exposition
    • Place of Presentation
      Convention Center, Indianapolis
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Self-healable and injectable PEG hydrogels via selective metal-ligand interaction2013

    • Author(s)
      Takeshi Sato, Mitsuhiro Ebara, Shinji Tanaka, Taka-aki Asoh, Akihiko Kikuchi, Takao Aoyagi
    • Organizer
      2013 BMES Annual Meeting
    • Place of Presentation
      Washington State Convention Center, Seattle
    • Related Report
      2013 Annual Research Report
  • [Presentation] Design of an inactivated Sendai virus immobilized film for the construction of a bioactive surface2013

    • Author(s)
      Takaharu Okada, Koichiro Uto, Mitsuhiro Ebara, Takao Aoyagi
    • Organizer
      IFCPAM 2013
    • Place of Presentation
      University of Auckland
    • Related Report
      2013 Annual Research Report
  • [Book] Polymer Journal2016

    • Author(s)
      Katsuhiko Ariga, Kosuke Minami, Mitsuhiro Ebara, and Jun Nakanishi
    • Total Pages
      19
    • Publisher
      What Are Emerging Concepts and Challenges in NANO?: Nanoarchitectonics, Hand-Operating Nanotechnology, and Mechanobiology
    • Related Report
      2015 Annual Research Report
  • [Book] バイオマテリアル-生体材料-2015

    • Author(s)
      新山瑛理,中川泰宏,荏原充宏
    • Total Pages
      10
    • Publisher
      バイオマテリアル学会
    • Related Report
      2015 Annual Research Report
  • [Book] Science and Technology of Advanced Materials2015

    • Author(s)
      Mitsuhiro Ebara
    • Total Pages
      13
    • Publisher
      Shape-Memory Surfaces for Cell Mechanobiology
    • Related Report
      2015 Annual Research Report
  • [Book] スマートポリマーの医療応用2014

    • Author(s)
      荏原充宏
    • Total Pages
      16
    • Publisher
      成型加工
    • Related Report
      2014 Annual Research Report
  • [Book] 指で温めて病原体を検出するスマート診断システム2014

    • Author(s)
      荏原充宏
    • Total Pages
      7
    • Publisher
      機能材料
    • Related Report
      2014 Annual Research Report
  • [Book] Chapter 14 Cell-Based Bioconjugates2014

    • Author(s)
      Mitsuhiro Ebara
    • Total Pages
      12
    • Publisher
      Wiley
    • Related Report
      2014 Annual Research Report
  • [Book] スマートゲルのバイオサイエンスへの応用2014

    • Author(s)
      荏原充宏, 青柳隆夫
    • Total Pages
      8
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2014 Annual Research Report
  • [Book] Bioinspired Nanoarchitectonics as Emerging Drug Delivery Systems2014

    • Author(s)
      Katsuhiko Ariga, Kohsaku Kawakami, Mitsuhiro Ebara, Yohei Kotsuchibashi, Qingmin Ji, Jonathan P Hill
    • Total Pages
      15
    • Publisher
      New Journal of Chemistry
    • Related Report
      2014 Annual Research Report
  • [Book] Chapter 12 Silica Nanoparticle Bioconjugates, Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications2014

    • Author(s)
      Mitsuhiro Ebara
    • Total Pages
      13
    • Publisher
      Wiley
    • Related Report
      2013 Annual Research Report
  • [Book] Chapter 12 Silica Nanoparticle Bioconjugates, Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications2014

    • Author(s)
      Yohei Kotsuchibashi, Mitsuhiro Ebara, Ravin Narain
    • Total Pages
      17
    • Publisher
      Wiley
    • Related Report
      2013 Annual Research Report
  • [Book] ナノファイバメッシュ2014

    • Author(s)
      荏原充宏
    • Total Pages
      4
    • Publisher
      応用物理
    • Related Report
      2013 Annual Research Report
  • [Book] 生分解性プラスチックを活用した形状記憶高分子の開発2013

    • Author(s)
      荏原充宏
    • Total Pages
      4
    • Publisher
      月刊Polyfile
    • Related Report
      2013 Annual Research Report
  • [Remarks] 荏原研究室HP

    • URL

      http://www.nims.go.jp/bmc/group/smartbiomaterials/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Patent(Industrial Property Rights)] エチレン-ビニルアルコール共重合体またはポリビニルアルコール機能化方法並びにエチレン-ビニルアルコール共重合体またはポリビニルアルコール機能化剤2015

    • Inventor(s)
      小土橋陽平, 荏原充宏
    • Industrial Property Rights Holder
      小土橋陽平, 荏原充宏
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-198316
    • Filing Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 産生信号誘発ポリマーの合成方法、産生信号誘発モノマー前駆体及び産生信号誘発ポリマー前駆体2014

    • Inventor(s)
      荏原充宏、青柳隆夫
    • Industrial Property Rights Holder
      荏原充宏、青柳隆夫
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-227661
    • Filing Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞間情報伝達分子産生信号誘発機能高分子及びその合成方法2013

    • Inventor(s)
      荏原充宏, 青柳隆夫
    • Industrial Property Rights Holder
      荏原充宏, 青柳隆夫
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-236845
    • Filing Date
      2013-11-15
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 血液浄化用膜、血液浄化用膜の製造方法及び透析装置2013

    • Inventor(s)
      荏原充宏, 滑川亘希, 青柳隆夫
    • Industrial Property Rights Holder
      荏原充宏, 滑川亘希, 青柳隆夫
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-174636
    • Filing Date
      2013-08-26
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2022-01-31  

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