Control of celluar functions by chemically functionalized nanocarbons
| Project/Area Number |
25702030
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Miyako Eijiro 国立研究開発法人産業技術総合研究所, ナノ材料研究部門, 主任研究員 (70443231)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | カーボンナノチューブ / 光発熱特性 / 近赤外光 / 細胞 |
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| Outline of Final Research Achievements |
A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, a comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near-infrared (NIR) laser irradiation. By exploiting the chemico-physical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single-cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single-cell analyses and innovative cell therapies.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Photofunctional nanomodulators for bioexcitation.2014
Author(s)
Miyako E, Russier J, MauroM, Cebrian C, Yawo H, Menard-Moyon C, Hutchison JA, Yudasaka M, Iijima S, De Cola L, Bianco A
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Journal Title
Angew Chem Int Ed.
Volume: 53
Issue: 48
Pages: 13121-13125
DOI
Related Report
Peer Reviewed
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[Presentation] Photofunctional nanomodulators for spatiotemporal bioexcitation2014
Author(s)
Eijiro Miyako, Julie Russier, Matteo Mauro, Cristina Cebrian, Hiromu Yawo, Cecilia Menard-Moyon, James A. Hutchison, Masako Yudasaka, Sumio Iijima, Luisa De Cola, Alberto Bianco
Organizer
第47回フラーレン・ナノチューブ・グラフェン総合シンポジウム
Place of Presentation
名古屋
Year and Date
2014-09-03
Related Report
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