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Control of celluar functions by chemically functionalized nanocarbons

Research Project

Project/Area Number 25702030
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Miyako Eijiro  国立研究開発法人産業技術総合研究所, ナノ材料研究部門, 主任研究員 (70443231)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywordsカーボンナノチューブ / 光発熱特性 / 近赤外光 / 細胞
Outline of Final Research Achievements

A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, a comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near-infrared (NIR) laser irradiation. By exploiting the chemico-physical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single-cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single-cell analyses and innovative cell therapies.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (39 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (2 results) Journal Article (11 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 11 results,  Acknowledgement Compliant: 9 results) Presentation (23 results) (of which Int'l Joint Research: 4 results,  Invited: 9 results) Remarks (3 results)

  • [Int'l Joint Research] CNRS/ストラスブール大学(フランス)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Optical regulation of carbon nanodots by chemical functionalization2016

    • Author(s)
      Svetlana A. Chechetka, Eijiro Miyako
    • Journal Title

      ChemistrySelect

      Volume: N.A. Issue: 8 Pages: 854-856

    • DOI

      10.1246/cl.160429

    • NAID

      130005254490

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Bioinspired polyaniline-functional natural hairs for pollen protection2016

    • Author(s)
      Svetlana A. Chechetka, Eijiro Miyako
    • Journal Title

      ChemistrySelect

      Volume: 1 Pages: 1061-1065

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Magnetically- and near infrared light-powered supramolecular nanotransporters for the remote control of enzymatic reactions2016

    • Author(s)
      Svetlana A. Chechetka, Eiji Yuba, Kenji Kono, Masako Yudasaka, Alberto Bianco, Eijiro Miyako
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: N.A.

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Light-active carbon nanodots from autoclaved bioresources2016

    • Author(s)
      Svetlana A. Chechetka, Eijiro Miyako
    • Journal Title

      ChemistrySelect

      Volume: 3 Pages: 608-611

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lipid nanotube tailored fabrication of unique shaped polydopamine nanofibers as photothermal converters2016

    • Author(s)
      Wuxiao Ding, Svetlana A. Chechetka, Mitsutoshi Masuda, Toshimi Shimizu, Masaru Aoyagi, Hiroyuki Minamikawa, Eijiro Miyako
    • Journal Title

      Chem. Eur. J.

      Volume: 22 Pages: 4345-4350

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design, synthesis, characterization and properties of magnetic nanoparticle-nanocarbon hybrids2016

    • Author(s)
      Eijiro Miyako, Benoit P. Pichon, Cecilia Menard-Moyon, Isabella Anna Vacchi, Christophe Lefevre, Sylvie Begin-Colin, Alberto Bianco
    • Journal Title

      Carbon

      Volume: 96 Pages: 49-56

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Physicochemically functionalized carbon nanohorns for multi-dimensional cancer elimination2016

    • Author(s)
      Svetlana A. Chechetka, Minfang Zhang, Masako Yudasaka, Eijiro Miyako
    • Journal Title

      Carbon

      Volume: 97 Pages: 45-53

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In vivo remote control of reactions in Caenorhabditis elegans by using supramolecular nanohybrids of carbon nanotubes and liposomes2015

    • Author(s)
      Eijiro Miyako, Svetlana A. Chechetka, Motomichi Doi, Eiji Yuba, Kenji Kono
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 54 Pages: 9903-9906

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Multifunctional carbon nanohorn complexes for cancer treatment2015

    • Author(s)
      Svetlana A. Chechetka, Benoit Pichon, Minfang Zhang, Masako Yudasaka, Sylvie Begin-Colin, Alberto Bianco, Eijiro Miyako
    • Journal Title

      Chemistry - An Asian Journal

      Volume: 10 Issue: 1 Pages: 160-165

    • DOI

      10.1002/asia.201403059

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Photofunctional nanomodulators for bioexcitation.2014

    • Author(s)
      Miyako E, Russier J, MauroM, Cebrian C, Yawo H, Menard-Moyon C, Hutchison JA, Yudasaka M, Iijima S, De Cola L, Bianco A
    • Journal Title

      Angew Chem Int Ed.

      Volume: 53 Issue: 48 Pages: 13121-13125

    • DOI

      10.1002/anie.201407169

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-assembled carbon nanotube honeycomb networks using a butterfly wing template as a multifunctional nanobiohybrid2013

    • Author(s)
      Eijiro Miyako, Takushi Sugino, Toshiya Okazaki, Alberto Bianco, Masako Yudasaka, Sumio Iijima
    • Journal Title

      ACS Nano

      Volume: 7 Issue: 10 Pages: 8736-8742

    • DOI

      10.1021/nn403083v

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ナノカーボン複合体を用いた動的分子ナノシステムの創製2016

    • Author(s)
      都 英次郎
    • Organizer
      第32回日本DDS学会学術集会
    • Place of Presentation
      グランシップ(静岡県静岡市)
    • Year and Date
      2016-06-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Carbon nanohorns for targeted therapy2016

    • Author(s)
      Eijiro Miyako
    • Organizer
      CIMTEC 2016
    • Place of Presentation
      Perugia, Italy
    • Year and Date
      2016-06-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Spatiotemporal control of cellular functions by NIR light-powered nanorobots2016

    • Author(s)
      Eijiro Miyako
    • Organizer
      第21回iCeMS国際シンポジウム
    • Place of Presentation
      京都大学(京都府左京区)
    • Year and Date
      2016-06-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多次元ガン治療のための機能性カーボンナノホーンの開発2016

    • Author(s)
      都 英次郎, Chechetka Svetlana, 張 民芳, 湯田坂 雅子
    • Organizer
      第50回フラーレン・ナノチューブ・グラフェン総合シンポジウム
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-02-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Functional carbon nanohorn complexes for multi-dimensional cancer elimination2016

    • Author(s)
      都 英次郎, Chechetka Svetlana, 張 民芳, 湯田坂 雅子
    • Organizer
      第 4 回 ナノカーボンバイオシンポジウム
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-02-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Photofunctional nanomodulators for bioexcitation2015

    • Author(s)
      Eijiro Miyako
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii, Honolulu, US
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of bioreactions in living organisms by carbon nanotube supramolecular nanohybrids2015

    • Author(s)
      都 英次郎, Chechetka Svetlana, 戸井 基道, 弓場 英司, 河野 健司
    • Organizer
      第49回 フラーレン・ナノチューブ・グラフェン 総合シンポジウム
    • Place of Presentation
      北九州国際会議場(福岡県小倉市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] バイオセンシングのためのカーボンナノチューブ-モルフォ翅複合材料の創製2015

    • Author(s)
      都 英次郎
    • Organizer
      第 3 回 ナノカーボンバイオシンポジウム
    • Place of Presentation
      北九州国際会議場(福岡県小倉市)
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] Photothermal conversion of functional nanocarbons for biotechnological applications2015

    • Author(s)
      Eijiro Miyako
    • Organizer
      NT15
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2015-06-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] カーボンナノチューブ-リポソーム超分子複合体による分子伝送システム2015

    • Author(s)
      都 英次郎
    • Organizer
      ナノ学会第13回大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-05-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Multifunctional carbon nanohorn complexes for cancer treatment2015

    • Author(s)
      Svetlana A. Chechetka, Benoit Pichon, Minfang Zhang, Masako Yudasaka, Sylvie Begin-Colin, Alberto Bianco, Eijiro Miyako
    • Organizer
      第48回フラーレン・ナノチューブ・グラフェン総合シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-02-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Photothermal property of nanocarbon complexes for nanobiotechnological applications2014

    • Author(s)
      Eijiro Miyako
    • Organizer
      The 10th SPSJ International Polymer Conference (IPC2014)
    • Place of Presentation
      つくば
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Photofunctional nanomodulators for spatiotemporal bioexcitation2014

    • Author(s)
      Eijiro Miyako, Julie Russier, Matteo Mauro, Cristina Cebrian, Hiromu Yawo, Cecilia Menard-Moyon, James A. Hutchison, Masako Yudasaka, Sumio Iijima, Luisa De Cola, Alberto Bianco
    • Organizer
      第47回フラーレン・ナノチューブ・グラフェン総合シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Light-driven functional nanocarbons for nanobiotechnological applications2014

    • Author(s)
      Eijiro Miyako
    • Organizer
      ナノカーボンバイオシンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2014-09-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional Nanocarbon Composites for Nanobiotechnology2014

    • Author(s)
      Eijiro Miyako
    • Organizer
      NIMS Conference 2014
    • Place of Presentation
      つくば
    • Year and Date
      2014-07-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Photothermal property of nanocarbon complexes for nanobiotechnological applications2014

    • Author(s)
      Eijiro Miyako
    • Organizer
      E-MRS 2014 SPRING MEETING
    • Place of Presentation
      Lille, France
    • Year and Date
      2014-05-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ナノカーボン材料の光発熱特性

    • Author(s)
      都 英次郎
    • Organizer
      ナノカーボンセミナー(NEC)
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Development of functional nanocarbon complex for photothermal technology

    • Author(s)
      都 英次郎
    • Organizer
      第23回 日本MRS年次大会
    • Place of Presentation
      横浜市 (神奈川県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Light-driven functional nanocarbon complexes for nanobiotechnological applications

    • Author(s)
      Eijiro Miyako
    • Organizer
      MANA seminar
    • Place of Presentation
      Tsukuba (Ibaraki)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Light-triggered photothermal property of nanocarbons for nanobiotechnological applications

    • Author(s)
      Eijiro Miyako
    • Organizer
      Carbon nanotechnology seminar at Trieste University
    • Place of Presentation
      Trieste (Italy)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Laser-triggered nanocarbons for spatiotemporal control of cellular functions

    • Author(s)
      Eijiro Miyako
    • Organizer
      ISIS seminar at Strasbourg University
    • Place of Presentation
      Strasbourg (France)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ナノバイオテクノロジーのための光で発熱する機能性ナノカーボン高分子複合材料の創製

    • Author(s)
      都 英次郎
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋市(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ナノバイオテクノロジーのための機能性ナノカーボン複合体の開発

    • Author(s)
      都 英次郎
    • Organizer
      LS-BT合同研究発表会
    • Place of Presentation
      つくば市(茨城県)
    • Related Report
      2013 Annual Research Report
  • [Remarks] 産業技術総合研究所プレスリリース

    • URL

      http://www.aist.go.jp/aist_j/press_release/pr2015/pr20150708/pr20150708.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 生きた細胞を光エネルギーで操作する技術を開発

    • URL

      http://www.aist.go.jp/aist_j/press_release/pr2014/pr20141027_3/pr20141027_3.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] Des nanomodulateurs diriges par la lumiere

    • URL

      http://www.cnrs.fr/inc/communication/direct_labos/bianco2.htm

    • Related Report
      2014 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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