Underlying pathogenesis of cartilage alterations caused by insufficient or excessive mechanical stresses
Project/Area Number |
25702032
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Rehabilitation science/Welfare engineering
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Research Institution | Kobe University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
|
Keywords | メカニカルストレス / 運動器 / リハビリテーション |
Outline of Final Research Achievements |
Joints are composed of several different tissues, and articular cartilage plays an important role in maintaining mechanical competence. Mechanical stresses are crucial for the maintenance of the morphologic and functional integrity of articular cartilage. Joints are susceptible to insufficient or excessive stresses, leading to joint degeneration. After insufficient stresses, the joint surface was intact, but thickness of both the total and uncalcified layer of articular cartilage were decreased. These changes may be mediated by metabolic changes in chondrocytes including accelerated aggrecan catabolism and exquisitely modulated matrix mineralization, and cartilage matrix degradation and resorption by subchondral osteoclasts. Cartilage degeneration without chondrocyte hypertrophy under disuse condition indicate the possible existence of mechanism which is different from excessive mechanical stresses.
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Report
(5 results)
Research Products
(12 results)
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[Presentation] ボツリヌス療法は中枢性麻痺後の関節拘縮の予防と治療において有効であるが、筋萎縮を助長する2017
Author(s)
崎谷直義, 渡部大地, 野村将人, 岩澤裕之, 島谷俊亮, 高野祥子, 小笠原慎, 脇本祥夫, 小原雄太, 鈴木崚太, 水野絵理子, 小澤淳也, 森山英樹
Organizer
第52回日本理学療法学術大会
Place of Presentation
幕張メッセ(千葉県・千葉市)
Year and Date
2017-05-12
Related Report
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[Presentation] 関節内におけるメカニカルストレスの分布の変化が関節軟骨に与える影響-マウス後肢非荷重および関節固定モデルを用いた実験的検討-2016
Author(s)
野村将人, 崎谷直義, 岩澤裕之, 髙野祥子, 小原雄太, 島谷俊亮, 脇本祥夫, 長井桃子, 飯島弘貴, 黒木裕士, 森山英樹
Organizer
第3回日本運動器理学療法学術集会
Place of Presentation
本多の森ホール(石川県・金沢市)
Year and Date
2016-12-03
Related Report
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[Presentation] 脊髄損傷後の骨折は通常と異なる骨化様式を経て早く治癒する2016
Author(s)
崎谷直義, 岩澤裕之, 野村将人, 脇本祥夫, 高野祥子, 小原雄太, 島谷俊亮, 伊藤明良, 長井桃子, 太治野純一, 張項凱, 山口将希, 飯島弘貴, 黒木裕士, 森山英樹
Organizer
第3回日本運動器理学療法学術集会
Place of Presentation
本多の森ホール(石川県・金沢市)
Year and Date
2016-12-03
Related Report
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[Presentation] 脊髄損傷後の痙性が関節拘縮に与える影響2016
Author(s)
島谷俊亮, 崎谷直義, 小澤淳也, 渡部大地, 野村将人, 脇本祥夫, 高野祥子, 小原雄太, 森山英樹
Organizer
第3回日本運動器理学療法学術集会
Place of Presentation
本多の森ホール(石川県・金沢市)
Year and Date
2016-12-03
Related Report
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