| Budget Amount *help |
¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
Joints are composed of several different tissues, and articular cartilage plays an important role in maintaining mechanical competence. Mechanical stresses are crucial for the maintenance of the morphologic and functional integrity of articular cartilage. Joints are susceptible to insufficient or excessive stresses, leading to joint degeneration. After insufficient stresses, the joint surface was intact, but thickness of both the total and uncalcified layer of articular cartilage were decreased. These changes may be mediated by metabolic changes in chondrocytes including accelerated aggrecan catabolism and exquisitely modulated matrix mineralization, and cartilage matrix degradation and resorption by subchondral osteoclasts. Cartilage degeneration without chondrocyte hypertrophy under disuse condition indicate the possible existence of mechanism which is different from excessive mechanical stresses.
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