The synchronized trial on expectant mothers with depressive symptoms by omega-3 PUFAs

• Project/Area Number: 25702043
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Applied health science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: NISHI DAISUKE 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所精神保健計画研究部, システム開発研究室長 (40450605)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000); Fiscal Year 2015: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: うつ病 / 母子保健 / 精神保健 / 栄養学 / オメガ3系脂肪酸 / オメガ３系脂肪酸

Outline of Final Research Achievements

We conducted an open-label pilot trial in pregnant women with depressive symptoms in Japan and Taiwan, and showed safety and potential efficacy of omega-3 polyunsaturated fatty acids (PUFAs) for improving depressive symptoms for the first time in Japan, where fish consumption is higher than in almost any other countries. Then we have conducted a multicenter, double-blind, parallel group, randomized controlled trial to determine the efficacy of omega-3 PUFAs in Japan and Taiwan, and have successfully recruited a sufficient number of participants.

Research Products

• [Int'l Joint Research] 中国医薬大学(台湾)
• [Int'l Joint Research] 中国医薬大学(台湾)
• [Journal Article] Psychological growth after childbirth: an exploratory prospective study (2017)
  • Author(s): Nishi D, Usuda K
  • Journal Title: Journal of Psychosomatic Obstetrics & Gynecology Volume: 38 Issue: 2 Pages: 87-93
  • DOI: 10.1080/0167482x.2016.1233170
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The synchronized trial on expectant mothers with depressive symptoms by omega-3 PUFAs (SYNCHRO): Study protocol for a randomized controlled trial (2016)
  • Author(s): Nishi D, Su KP, Usuda K, Chiang YJ, Guu TW, Hamazaki K, Nakaya N, Sone T, Sano Y, Tachibana Y, Ito H, Isaka K, Hashimoto K, Hamazaki T, Matsuoka YJ.
  • Journal Title: BMC psychiatry Volume: 16 Issue: 1 Pages: 321-321
  • DOI: 10.1186/s12888-016-1031-2
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prevalence and related factors of common mental disorders during pregnancy in Japan: a cross-sectional study (2016)
  • Author(s): Usuda K, Nishi D, Makino M, Tachimori H, Matsuoka Y, Sano Y, Konishi T, Takeshima T
  • Journal Title: BioPsychoSocial Medicine Volume: 10 Issue: 1 Pages: 17-17
  • DOI: 10.1186/s13030-016-0077-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] オメガ3系脂肪酸による精神疾患へのアプローチ (2016)
  • Author(s): 西大輔、松岡豊
  • Journal Title: 日本生物学的精神医学会誌 Volume: 27 Pages: 182-187
  • NAID: 130007402109
• [Journal Article] 妊娠期のうつへのアプローチ (2016)
  • Author(s): 西大輔
  • Journal Title: 日本産科婦人科学会雑誌 Volume: 68 Pages: 388-388
• [Journal Article] Omega-3 fatty acid supplementation for expectant mothers with depressive symptoms in Japan and Taiwan: an open-label trial (2016)
  • Author(s): 2)Nishi D, Su KP, Usuda K, Chiang YJ, Guu TW, Hamazaki K, Nakaya N, Sone T, Sano Y, Ito H, Isaka K, Hashimoto K, Hamazaki T, Matsuoka YJ
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 70 Issue: 6 Pages: 253-4
  • DOI: 10.1111/pcn.12388
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 出産に関するプレッシャーと産後抑うつ症状の関連についての縦断的検討 (2016)
  • Author(s): 臼田謙太郎、西大輔、佐野養、松岡豊
  • Journal Title: 総合病院精神医学 Volume: 28 Pages: 182-7
  • NAID: 130007616431
  • Peer Reviewed
• [Journal Article] International Society for Nutritional Psychiatry Research consensus position statement: nutritional medicine in modern psychiatry (2015)
  • Author(s): Sarris J, Logan AC, Akbaraly TN, Amminger GP, Balanza-Martinez V, Freeman MP, Hibbeln J, Matsuoka Y, Mischoulon D, Mizoue T, Nanri A, Nishi D, Ramsey D, Rucklidge J, Sanchez-Villegas A, Scholey A, Su KP, Jacka FN
  • Journal Title: World Psychiatry Volume: 14 Issue: 3 Pages: 370-1
  • DOI: 10.1002/wps.20223
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Implementation of Psychiatric-Focused Lifestyle Medicine Programs in Asia (2015)
  • Author(s): Sarris J, Nishi D, Xiang YT, Su KP, Bannatyne A, Oliver G, Heok KE, Chee N
  • Journal Title: Asia-Pacific Psychiatry Volume: 7 Issue: 4 Pages: 345-54
  • DOI: 10.1111/appy.12212
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nutritional medicine as mainstream in psychiatry (2015)
  • Author(s): 34)Sarris J, Logan AC, Akbaraly TN, Amminger GP, Balanza-Martinez V, Freeman MP, Hibbeln J, Matsuoka Y, Mischoulon D, Mizoue T, Nanri A, Nishi D, Ramsey D, Rucklidge J, Sanchez-Villegas A, Scholey A, Su KP, Jacka FN
  • Journal Title: Lancet Psychiatry Volume: 2 Issue: 3 Pages: 271-74
  • DOI: 10.1016/s2215-0366(14)00051-0
  • Peer Reviewed
• [Journal Article] Serum neuropeptide Y in accident survivors with depression or posttraumatic stress disorder (2014)
  • Author(s): Nishi D, Hashimoto K, Noguchi H, Matsuoka Y
  • Journal Title: Neuroscience Research Volume: 83 Pages: 8-12
  • DOI: 10.1016/j.neures.2014.03.009
  • Peer Reviewed
• [Journal Article] The role of high-density lipoprotein cholesterol in risk for posttraumatic stress disorder: Taking a nutritional approach toward universal prevention (2014)
  • Author(s): Hamazaki K, Nishi D, Yonemoto N, Noguchi H, Kim Y, Matsuoka Y
  • Journal Title: Eur Psychiatry Volume: 29 Issue: 7 Pages: 408-13
  • DOI: 10.1016/j.eurpsy.2014.05.002
  • Peer Reviewed
• [Journal Article] Hypnosis for induction of labour. (2014)
  • Author(s): Nishi D, Shirakawa MN, Ota E, Hanada N, Mori R
  • Journal Title: The Cochrane database of systematic reviews Volume: Aug 14;8 Issue: 8
  • DOI: 10.1002/14651858.cd010852.pub2
  • Peer Reviewed / Open Access
• [Journal Article] 妊娠うつ病予防に対するω3系脂肪酸の可能性 (2014)
  • Author(s): 臼田謙太郎、西大輔、松岡豊
  • Journal Title: 心身医学 Volume: 54 Pages: 248-53
• [Journal Article] PTSDの予防と緩和における魚油の可能性 (2014)
  • Author(s): 野口普子、西大輔、松岡豊
  • Journal Title: 心身医学 Volume: 54 Pages: 849-55
• [Journal Article] Culturally sensitive and universal measure of resilience for Japanese populations: Tachikawa Resilience Scale in comparison with Resilience Scale 14-item version (2013)
  • Author(s): Nishi D, Uehara R, Yoshikawa E, Sato G, Ito M, Matsuoka Y
  • Journal Title: Psychiat Clin Neurosci Volume: 67 Issue: 3 Pages: 174-181
  • DOI: 10.1111/pcn.12028
  • Peer Reviewed
• [Journal Article] Incidence and prediction of posttraumatic stress disorder at 6 months after motor vehicle accident in Japan (2013)
  • Author(s): Nishi D, Noguchi H, Yonemoto N, Nakajima S, Kim Y, Matsuoka Y
  • Journal Title: Psychosomatics Volume: 54 Issue: 3 Pages: 263-271
  • DOI: 10.1016/j.psym.2012.07.010
  • Peer Reviewed
• [Journal Article] Longitudinal changes in serum brain-derived neurotrophic factor in accidient survivors with posttraumatic stress disorder (2013)
  • Author(s): Matsuoka Y., Nishi D., Noguchi H., Kim Y., Hashimoto K
  • Journal Title: Neuropsychobiology Volume: 68 Issue: 1 Pages: 44-50
  • DOI: 10.1159/000350950
  • Peer Reviewed
• [Journal Article] Serum Levels of Polyunsaturated Fatty Acids and the Risk of Posttraumatic Stress Disorder (2013)
  • Author(s): Matsuoka Y, Nishi D, Hamazaki K
  • Journal Title: Psychother Psychosom Volume: 82 Issue: 6 Pages: 408-410
  • DOI: 10.1159/000351993
  • Peer Reviewed
• [Journal Article] Does Prior Trauma Predict Negative Posttraumatic Appraisal in Motor Vehicle Accident Survivors? (2013)
  • Author(s): Noguchi H, Nishi D, Kim Y, Konishi T, Matsuoka Y
  • Journal Title: J Depress Anxiety Volume: S4 Pages: 3-3
  • DOI: 10.4172/2167-1044.s4-003
  • Peer Reviewed
• [Journal Article] Hypnosis for induction of labour (Protocol) (2013)
  • Author(s): Nishi D, Shirakawa MN, Ota E, Hanada N, Mori R
  • Journal Title: Cochrane Database of Systematic Reviews Volume: CD010852
  • DOI: 10.1002/14651858.cd010852
  • Peer Reviewed
• [Journal Article] Associations between Disaster Exposures, Peritraumatic Distress, and Posttraumatic Stress Responses in Fukushima Nuclear Plant Workers following the 2011 Nuclear Accident: The Fukushima NEWS Project Study (2013)
  • Author(s): Shigemura J, Tanigawa T, Nishi D, Matsuoka Y, Nomura S, Yoshino A
  • Journal Title: PLoS ONE Volume: 7 Issue: 2 Pages: e87516-e87516
  • DOI: 10.1371/journal.pone.0087516
  • Peer Reviewed
• [Journal Article] うつ病とPTSDに対するオメガ3系脂肪酸のエビデンス (2013)
  • Author(s): 西大輔、松岡豊
  • Journal Title: 総合病院精神医学 Volume: 25 Pages: 248-253
  • NAID: 130006832758
  • Peer Reviewed
• [Presentation] Omega-3 fatty acids for pregnant women with depressive symptoms in Japan and Taiwan: an open-label trial (2016)
  • Author(s): Nishi D, Su KP, Usuda K, Chiang YJ, Guu TW, Hamazaki K, Nakaya N, Sone T, Sano Y, Ito H, Isaka K, Hashimoto K, Hamazaki T, Matsuoka YJ
  • Organizer: 14th International Congress of Behavioral Medicine
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2016-12-07
  • Int'l Joint Research
• [Presentation] 妊娠中の精神疾患の有病率と関連因子および産後うつ症状の予測因子の検討 (2016)
  • Author(s): 臼田謙太郎、西大輔、立森久照、佐野養、松岡豊
  • Organizer: 第29回日本総合病院精神医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-11-25
• [Presentation] Omega-3 fatty acids in the treatment of pregnant women with depressive symptoms in Japan and Taiwan: a cultural perspective (2016)
  • Author(s): Nishi D, Su KP, Usuda K, Chiang YJ, Guu TW, Hamazaki K, Nakaya N, Sone T, Hashimoto K, Hamazaki T, Matsuoka YJ
  • Organizer: 17th Pacific Rim College of Psychiatrists Scientific Meeting
  • Place of Presentation: Kaohsiung, Taiwan
  • Year and Date: 2016-11-03
  • Int'l Joint Research
• [Presentation] Feeling social pressure as a predictor for common mental disorders (CMD) during pregnancy and postpartum depressive symptoms (2016)
  • Author(s): Usuda K, Nishi D, Sano Y, Matsuoka YJ
  • Organizer: 17th Pacific Rim College of Psychiatrists Scientific Meeting
  • Place of Presentation: Kaohsiung, Taiwan
  • Year and Date: 2016-11-03
  • Int'l Joint Research
• [Presentation] 妊婦におけるうつ症状軽減を目指したオメガ3系脂肪酸によるオープン試験 (2016)
  • Author(s): 西大輔、Kuan-Pin Su、臼田謙太郎、Yi-Ju Jill Chiang、Tai-Wei Guu、浜崎景、中谷直樹、曽根稔雅、佐野養、伊東宏絵、井坂恵一、橋本謙二、浜崎智仁、松岡豊
  • Organizer: 第25回日本脂質栄養学会
  • Place of Presentation: 秋田
  • Year and Date: 2016-09-16
• [Presentation] 妊婦のうつ症状に対するオメガ3系脂肪酸の可能性 (2016)
  • Author(s): 西大輔
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
  • Place of Presentation: 福岡
  • Year and Date: 2016-09-08
• [Presentation] 妊娠期のうつへのアプローチ (2016)
  • Author(s): 西大輔
  • Organizer: 第68回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-21
  • Invited
• [Presentation] Fish consumption frequency and resilience to depression in Japan (2015)
  • Author(s): Nishi D, Yoshikawa E, Matsuoka Y
  • Organizer: The 5th Mind-Body Interface International Symposium
  • Place of Presentation: Taichung, Taiwan
  • Year and Date: 2015-10-20
  • Int'l Joint Research
• [Presentation] オメガ3系脂肪酸による精神疾患へのアプローチ (2015)
  • Author(s): 西大輔、松岡豊
  • Organizer: 第37回日本生物学的精神医学会・第45回日本神経精神薬理学会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-25
• [Presentation] Are omega-3 PUFAs effective for depression during pregnancy in countries where fish consumptions are high? (2015)
  • Author(s): Nishi D, Matsuoka Y
  • Organizer: The 23rd World Congress on Psychosomatic Medicine
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2015-08-19
  • Int'l Joint Research
• [Presentation] Prevalence and risk factors for common mental disorders in mid-pregnant women in Japan (2015)
  • Author(s): Usuda K, Nishi D, Makino M, Tachimori H, Matsuoka Y, Sono Y, Shimada H, Ito H, Isaka K, Konishi T, Takeshima T
  • Organizer: 6th World Congress on Women's Mental Health
  • Place of Presentation: Keio Plaza Hotel, Tokyo, Japan
  • Year and Date: 2015-03-22 – 2015-03-25
• [Presentation] Fish oil for selective prevention of posttraumatic stress disorder among severely injured patients: a randomized, placebo-controlled trial (2015)
  • Author(s): Matsuoka Y, Nishi D, Hamazaki K, Yonemoto N, Matsumura K, Noguchi H, Hashimoto K, Hamazaki T
  • Organizer: 73rd American Psychosomatic Society
  • Place of Presentation: Hyatt Regency, Savannah, USA
  • Year and Date: 2015-03-18 – 2015-03-21
• [Presentation] Omega-3 PUFAs for depressive symptoms in pregnant women – An open label trial (2014)
  • Author(s): Nishi D
  • Organizer: Joint Symposium 2014 Department of Psychiatry & National Center of Neurology and Psychiatry
  • Place of Presentation: Kenneth Myer Auditorium, Melbourne Brain Institute, Melbourne, Australia
  • Year and Date: 2014-11-19
• [Presentation] The synchronized trial on expectant mothers with depressive symptoms by omega-3 PUFAs (SYNCHRO): Study protocol (2014)
  • Author(s): Nishi D, Su KP, Usuda K, Hamazaki K, Matsuoka Y
  • Organizer: the Mind-Body Interface International Workshop
  • Place of Presentation: China Medical University, Taichung, Taiwan
  • Year and Date: 2014-10-29
• [Presentation] Omega-3 fatty acids for posttraumatic stress symptoms in rescue workers after the Great East Japan Earthquake (2014)
  • Author(s): Nishi D, Koido Y, Nakaya N, Sone T, Noguchi H, Hamazaki K, Hamazaki T, Matsuoka Y
  • Organizer: World Psychiatric Association Section on Epidemiology and Public Health
  • Place of Presentation: Nara Kasugano International Forum, Nara, Japan
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] Docosahexaenoic acid for selective prevention of posttraumatic stress disorder among severely injured patients: a randomized, placebo controlled trial. (2014)
  • Author(s): Matsuoka Y, Nishi D, Hamazaki K, Yonemoto N, Matsumura K, Noguchi H, Hashimoto K, Hamazaki T
  • Organizer: 16th World Congress of Psychiatry
  • Place of Presentation: Centro de Convenciones Norte, Madrid, Spain
  • Year and Date: 2014-09-14 – 2014-09-18
• [Presentation] HDLコレステロールと心的外傷後ストレス障害の発症リスク (2014)
  • Author(s): 松岡豊、浜崎景、西大輔、米本直裕、野口普子、金吉晴
  • Organizer: 第23回日本脂質栄養学会
  • Place of Presentation: 東京都、東京国際交流館プラザ平成
  • Year and Date: 2014-08-29 – 2014-08-30
• [Presentation] Docosahexaenoic acid for selective prevention of posttraumatic stress disorder among severely injured patients: A randomized, placebo-controlled trial (2014)
  • Author(s): Matsuoka Y, Nishi D, Hamazaki K, Yonemoto N, Matsumura K, Noguchi H, Hashimoto K, Hamazaki T
  • Organizer: International Society for Fatty Acids and Lipids
  • Place of Presentation: Hilton Stockholm Slussen Hotel, Stockholm, Sweden
  • Year and Date: 2014-06-28 – 2014-07-02
• [Presentation] Omega-3 fatty acids for depressive symptoms in pregnant women - Protocol (2014)
  • Author(s): Nishi D, Kuan-Pin Su, Hamazaki K, Matsuoka Y
  • Organizer: 2nd International Society for Nutritional Psychiatry Research
  • Place of Presentation: Deakin city campus, Melbourne, Australia
  • Year and Date: 2014-04-03 – 2014-04-04
• [Presentation] The role of polyunsaturated fatty acids and lipids in risk for posttraumatic stress disorder (2014)
  • Author(s): Matsuoka Y, Hamazaki K, Nishi D
  • Organizer: 2nd International Society for Nutritional Psychiatry Research
  • Place of Presentation: Deakin city campus, Melbourne, Australia
  • Year and Date: 2014-04-03 – 2014-04-04
• [Presentation] PTSDの予防と緩和における魚油の可能性 (2014)
  • Author(s): 西大輔、松岡豊
  • Organizer: 日本不安障害学会学術大会
  • Place of Presentation: 東京大学伊藤謝恩ホール、東京
• [Presentation] 血清多価不飽和脂肪酸と心的外傷後ストレス障害の発症リスク：立川交通事故コホート研究 (2014)
  • Author(s): 松岡豊、西大輔、浜崎景
  • Organizer: 日本疫学会学術総会
  • Place of Presentation: 日立システムズホール仙台、仙台
• [Presentation] 交通外傷患者の否定的な認知的評価と性格特性との関連についての検討 (2014)
  • Author(s): 野口普子、西大輔、金吉晴、松岡豊
  • Organizer: 日本不安障害学会学術大会
  • Place of Presentation: 東京大学伊藤謝恩ホール、東京
• [Presentation] Omega-3 fatty acids for attenuating posttraumatic stress symptoms after the earthquake: a randomized controlled trial (2013)
  • Author(s): Nishi D, Matsuoka Y
  • Organizer: World Congress on Psychosomatic Medicine
  • Place of Presentation: Lisbon Marriott Hotel, Lisbon, Portugal
• [Presentation] Incidence and prediction of posttramatic stress disorder at 6 months after motor vehicle accident in Japan (2013)
  • Author(s): Matsuoka Y, Nishi D, Noguchi H, Yonemoto N, Nakajima S, Kim Y
  • Organizer: World Congress on Psychosomatic Medicine
  • Place of Presentation: Lisbon Marriott Hotel, Lisbon, Portugal
• [Presentation] Does prior trauma predict negative posttraumatic appraisal in accident survivors? (2013)
  • Author(s): Noguchi H, Nishi D, Kim Y, Konishi T, Matsuoka Y
  • Organizer: World Congress on Psychosomatic Medicine
  • Place of Presentation: Lisbon Marriott Hotel, Lisbon, Portugal
• [Presentation] Propofol injection may link to posttraumatic stress disorder after motor vehicle accident: a longitudinal study (2013)
  • Author(s): Usuki M, Matsuoka Y, Nishi D, Yonemoto N, Matsumura K, Otomo Y, Kim Y, Kanba S
  • Organizer: World Congress on Psychosomatic Medicine
  • Place of Presentation: Lisbon Marriott Hotel, Lisbon, Portugal
• [Presentation] 震災後の救援者における魚油のPTSD症状に対する有効性の検討：ランダム化比較試験 (2013)
  • Author(s): 西大輔
  • Organizer: 日本脂質栄養学会
  • Place of Presentation: 高知会館、高知
  • Invited
• [Presentation] 日本人に特有のレジリエンスはあるか？ (2013)
  • Author(s): 西大輔
  • Organizer: 日本トラウマティックストレス学会
  • Place of Presentation: 帝京平成大学、東京
• [Presentation] うつ病とPTSDに対するオメガ3系脂肪酸のエビデンス (2013)
  • Author(s): 西大輔、浜崎景、浜崎智仁、松岡豊
  • Organizer: 日本精神神経学会学術総会
  • Place of Presentation: 福岡国際会議場、福岡
• [Presentation] PTSDの予防と緩和における魚油の可能性 (2013)
  • Author(s): 松岡豊、西大輔
  • Organizer: 日本心身医学会総会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] 妊娠うつ病予防に対するオメガ3系脂肪酸の可能性 (2013)
  • Author(s): 西大輔、松岡豊
  • Organizer: 日本心身医学会総会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] 交通外傷直後のプロポフォール投与がPTSD症状に与える影響について (2013)
  • Author(s): 臼杵理人、松岡豊、西大輔、金吉晴、神庭重信
  • Organizer: 日本精神神経学会学術総会
  • Place of Presentation: 福岡国際会議場、福岡
• [Presentation] 東日本大震災の救援者におけるPTSD症状の予測因子に関する縦断研究 (2013)
  • Author(s): 松岡豊、西大輔、浜崎景、浜崎智仁
  • Organizer: 日本精神神経学会学術総会
  • Place of Presentation: 福岡国際会議場、福岡
• [Presentation] 血清多価不飽和脂肪酸と心的外傷後ストレス障害の発症リスク (2013)
  • Author(s): 松岡豊、西大輔、浜崎景
  • Organizer: 日本脂質栄養学会
  • Place of Presentation: 高知会館、高知
• [Presentation] Omega-3 fatty acids for attenuating posttraumatic stress symptoms among rescue workers after the Great East Japan Earthquake: A randomized controlled trial
  • Author(s): Nishi D, Matsuoka Y
  • Organizer: International Society for Nutritional Psychiatry Research
  • Place of Presentation: National Institute of Health and Nutrition, Tokyo, Japan
• [Presentation] Omega-3 fatty acids versus placebo for secondary prevention of PTSD after accidental injury: A randomised controlled trial
  • Author(s): Matsuoka Y, Nishi D
  • Organizer: International Society for Nutritional Psychiatry Research
  • Place of Presentation: National Institute of Health and Nutrition, Tokyo, Japan
• [Remarks] ClinicalTrials.gov
  • URL: https://clinicaltrials.gov/ct2/show/NCT01948596?term=synchro&rank=2
• [Remarks] ClinicalTrials.gov
  • URL: https://clinicaltrials.gov/ct2/show/NCT02166424?term=synchro&rank=1