| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
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| Outline of Final Research Achievements |
Arterial stiffness increases with age and becomes a strong risk for future cardiovascular disease. We determined underlying mechanisms of individual difference in age-related arterial stiffening from the view of genotype (e.g., polymorphism) and regular physical activity. We re-performed arterial stiffness measurement in 90 individuals (39 women, baseline age: 53±15 yrs) who engaged other experiments conducted in our laboratory approximately 10 years ago. Arterial stiffness increased by 12% in average, but individuals who had <15 METs/wk of regular aerobic exercise exhibited substantially smaller magnitude of age-related increase in arterial stiffness (+5.4%). This longitudinal investigation confirms the favorable effect of regular physical activity on age-related arterial stiffening. We are investigating the effect of interaction between genotype and regular physical activity.
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