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Underlying Mechanisms of Individual Difference in Age-related Arterial Stiffening

Research Project

Project/Area Number 25702045
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Applied health science
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Sugawara Jun  国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (00357261)

Research Collaborator MAEDA Seiji  筑波大学, 体育系, 教授
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Keywords動脈硬化 / 心血管疾患リスク / 加齢 / 身体活動 / 遺伝子多型 / 心血管疾患 / 動脈硬化度 / ライフスタイル
Outline of Final Research Achievements

Arterial stiffness increases with age and becomes a strong risk for future cardiovascular disease. We determined underlying mechanisms of individual difference in age-related arterial stiffening from the view of genotype (e.g., polymorphism) and regular physical activity. We re-performed arterial stiffness measurement in 90 individuals (39 women, baseline age: 53±15 yrs) who engaged other experiments conducted in our laboratory approximately 10 years ago. Arterial stiffness increased by 12% in average, but individuals who had <15 METs/wk of regular aerobic exercise exhibited substantially smaller magnitude of age-related increase in arterial stiffness (+5.4%). This longitudinal investigation confirms the favorable effect of regular physical activity on age-related arterial stiffening. We are investigating the effect of interaction between genotype and regular physical activity.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (7 results)

All 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 3 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Int'l Joint Research] テキサス大学オースティン校(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Relation between Arterial Stiffness and Aerobic Capacity: Importance of Proximal Aortic Stiffness2017

    • Author(s)
      Tomoto T, Maeda S, Sugawara J.
    • Journal Title

      Eur J Sport Sci

      Volume: 17 Issue: 5 Pages: 571-575

    • DOI

      10.1080/17461391.2016.1277787

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Arterial Path Length for Arterial Stiffness: Methodological Consideration2016

    • Author(s)
      Sugawara J, Hayashi K, Tanaka H.
    • Journal Title

      Am J Hypertens

      Volume: 29(11) Issue: 11 Pages: 1237-1244

    • DOI

      10.1093/ajh/hpw075

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Influence of blood flow velocity on arterial distensibility of carotid artery in healthy men2016

    • Author(s)
      Tsubasa Tomoto, Seiji Maeda, Jun Sugawara
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 5 Issue: 1 Pages: 1-6

    • DOI

      10.1007/s12576-016-0455-2

    • NAID

      40021064618

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 動脈スティフネスの加齢変化に対する習慣的な有酸素性運動の効果―10年間のフォローアップ研究―2016

    • Author(s)
      菅原順、東本翼
    • Organizer
      第4回日本介護福祉健康づくり学会
    • Place of Presentation
      柏の葉(千葉県)
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] 近位大動脈スティフネスの臨床医学的意義2016

    • Author(s)
      菅原 順、東本 翼、田中弘文
    • Organizer
      第16回臨床血圧脈波研究会
    • Place of Presentation
      品川(東京)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Influence of Regular Physical Activity on Vascular Aging.2016

    • Author(s)
      Jun Sugawara
    • Organizer
      Annual Convention & Scientific Session of the Taiwan Society of Cardiology
    • Place of Presentation
      Taipei(Taiwan)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2013-05-21   Modified: 2019-07-29  

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