Underlying Mechanisms of Individual Difference in Age-related Arterial Stiffening
| Project/Area Number |
25702045
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | National Institute of Advanced Industrial Science and Technology |
|---|
Principal Investigator |
Sugawara Jun 国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (00357261)
|
|---|
| Research Collaborator |
MAEDA Seiji 筑波大学, 体育系, 教授
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
|
|---|
| Keywords | 動脈硬化 / 心血管疾患リスク / 加齢 / 身体活動 / 遺伝子多型 / 心血管疾患 / 動脈硬化度 / ライフスタイル |
|---|
| Outline of Final Research Achievements |
Arterial stiffness increases with age and becomes a strong risk for future cardiovascular disease. We determined underlying mechanisms of individual difference in age-related arterial stiffening from the view of genotype (e.g., polymorphism) and regular physical activity. We re-performed arterial stiffness measurement in 90 individuals (39 women, baseline age: 53±15 yrs) who engaged other experiments conducted in our laboratory approximately 10 years ago. Arterial stiffness increased by 12% in average, but individuals who had <15 METs/wk of regular aerobic exercise exhibited substantially smaller magnitude of age-related increase in arterial stiffness (+5.4%). This longitudinal investigation confirms the favorable effect of regular physical activity on age-related arterial stiffening. We are investigating the effect of interaction between genotype and regular physical activity.
|
Report
(5 results)
Research Products
(7 results)
