|Budget Amount *help
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|Outline of Final Research Achievements
So far, a large number of natural products (around half a million) has been catalogued in databases. They show unique, complex chemical structures, which make themselves as attractive resources for drug candidates and research tools. In this research project, we have worked on natural products with a molecular function of ‘membrane binding’. This is because a variety of chemotypes has been and will be disclosed to have unique interactions with cell membranes. In addition, research tools are requisite for deeper understanding of the cell membrane. Finally, we have to remember that the cell membrane is one of the major targets of antimicrobials. In this project, we discovered several new natural products and revealed their molecular functions. Functions and regulation mechanisms of membrane lipids were investigated using them as chemical tools. In summary, we successfully demonstrated that chemical genetics is a powerful approach for investigating cell membranes.