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Development of versatile N-oxide-based fluorescent probes to study pathological dysfunction of iron metabolism

Research Project

Project/Area Number 25702050
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Chemical biology
Research InstitutionGifu Pharmaceutical University

Principal Investigator

Hirayama Tasuku  岐阜薬科大学, 薬学部, 准教授 (10600207)

Research Collaborator NIWA Masato  
TSUBOI Hitomi  
KADOTA Satoki  
IKESHITA Yukie  
MIKI Ayaji  
KATABE Tomoyo  
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Keywords鉄 / イメージング / 蛍光プローブ / 鉄イオン / 鉄代謝 / 蛍光イメージング
Outline of Final Research Achievements

We have developed a series of fluorescent probes for Fe(II) ion, which is an important chemical species in the iron metabolism, to study biological and pathological roles of iron ion in living cells. The design concept of Fe(II) fluorescent probe is based on N-oxide chemistry, where Fe(II) ion selectively reduces N-oxide by deoxygenation. In this research, we have succeeded in development of a color variation of the probes ranging from blue to deep-red by utilizing N-oxide chemistry as a selective fluorogenic molecular switch. We have also developed a membrane-anchoring fluorescent probe to visualize release of Fe(II) ion during endocytotic uptake of iron induced by transferrin/transferrin receptor interaction.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (55 results)

All 2017 2016 2015 2014 2013

All Journal Article (12 results) (of which Peer Reviewed: 11 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (41 results) (of which Int'l Joint Research: 6 results,  Invited: 6 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Chemical tools for detecting Fe ions2017

    • Author(s)
      Hirayama T. and Nagasawa H.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 60 Issue: 1 Pages: 39-48

    • DOI

      10.3164/jcbn.16-70

    • NAID

      130005188906

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of hemoglobin and transferrin in multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis.2016

    • Author(s)
      Wang Y, Okazaki Y, Shi L, Kohda H, Tanaka M, Taki K, Nishioka T, Hirayama T, Nagasawa H, Yamashita Y, Toyokuni S.
    • Journal Title

      Cancer Sci

      Volume: 107(3) Issue: 3 Pages: 250-257

    • DOI

      10.1111/cas.12865

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contrasting intra- and extra-cellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis.2016

    • Author(s)
      F. Ito, T. Nishiyama, L. Shi, M. Mori, T. Hirayama, H. Nagasawa, H. Yasui, S. Toyokuni
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 476 Issue: 4 Pages: 600-606

    • DOI

      10.1016/j.bbrc.2016.06.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iron stimulates plasma-activated medium-induced A549 cell injury2016

    • Author(s)
      Adachi T, Nonomura S, Horiba M, Hirayama T, Kamiya T, Nagasawa H, HaraH
    • Journal Title

      Sci Reports

      Volume: 6 Issue: 1 Pages: 20928-20928

    • DOI

      10.1038/srep20928

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nordihydroguaiaretic acid disrupts the antioxidant ability of Helicobacter pylori through the repression of SodB activity in vitro.2015

    • Author(s)
      Tsugawa, H., Mori, H., Matsuzaki, J., Masaoka, T., Hirayama, T., Nagasawa, H., Sakakibara, Y., Suematsu, M., Suzuki, H.
    • Journal Title

      Biomed. Res. Int.

      Volume: 2015 Pages: 734548-734548

    • DOI

      10.1155/2015/734548

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron2015

    • Author(s)
      M. Mori, F. Ito, L. W. Shi, C. Ishida, Y. Hattori, M. Niwa, T. Hirayama, H. Nagasawa, A. Iwase, F. Kikkawa, S. Toyokuni
    • Journal Title

      Redox Biology

      Volume: 6 Pages: 578-586

    • DOI

      10.1016/j.redox.2015.10.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Catalytic ferrous ion in amniotic fluid as a predictive marker of human maternal-fetal disorders2015

    • Author(s)
      Y. Hattori, T. Mukaide, L. Jiang, T. Kotani, H. Tsuda, Y. Mano, S. Sumigawa, T. Hirayama, H. Nagasawa, F. Kikkawa, S. Toyokuni
    • Journal Title

      Journal of Clinical Biochemistry and Nurition

      Volume: 56 Pages: 57-63

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-oxideの化学を利用した鉄(II)イオン蛍光プローブ分子の開発2015

    • Author(s)
      平山祐、丹羽正人、奥田健介、永澤秀子
    • Journal Title

      Chemical Biology

      Volume: 8 Pages: 9-11

    • Related Report
      2015 Annual Research Report
    • Open Access / Acknowledgement Compliant
  • [Journal Article] Facile One-Pot Synthesis of [1, 2, 3]Triazolo[1, 5-a]Pyridines from 2-Acylpyridines by Copper(II)-Catalyzed Oxidative N―N Bond Formation2014

    • Author(s)
      T. Hirayama, S. Ueda, T. Okada, N. Tsurue, K. Okuda, and H. Nagasawa
    • Journal Title

      Chemistry A European Journal

      Volume: 20 Issue: 14 Pages: 4156-4162

    • DOI

      10.1002/chem.201302997

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxyl radicals cause fluctuation in intracellular ferrous ion levels upon light exposure during photoreceptor cell death2014

    • Author(s)
      T. Imamura, T. Hirayama, K. Tsuruma, M. Shimazawa, H. Nagasawa, and H. Hara
    • Journal Title

      Experimental Eye Research

      Volume: 129 Pages: 24-30

    • DOI

      10.1016/j.exer.2014.10.019

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histological detection of catalytic ferrous iron with the selective turn-on fluorescent probe RhoNox-1 in a Fenton reaction-based rat renal carcinogenesis model.2014

    • Author(s)
      Mukaide T, Hatori Y, Misawa N, Funahashi S, Jiang L, Hirayama T, Nagasawa H,Toyokuni S
    • Journal Title

      Free Radic Res.

      Volume: 48 Issue: 9 Pages: 990-5

    • DOI

      10.3109/10715762.2014.898844

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin.2014

    • Author(s)
      Niwa, M., Hirayama, T., Okuda, K., Nagasawa, H.
    • Journal Title

      Org. Biomol. Chem.

      Volume: 12 Issue: 34 Pages: 6590-6597

    • DOI

      10.1039/c4ob00935e

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 生体内の鉄イオン変動を検出する新しいツール分子の開発と応用2017

    • Author(s)
      平山 祐
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 二価鉄蛍光プローブの開発とがん細胞における鉄動態解析への応用2017

    • Author(s)
      平山 祐、丹羽 正人、永澤 秀子
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞中での拡散性を高めた鉄(II)イオン蛍光プローブの開発2017

    • Author(s)
      丹羽 正人、平山 祐、奥田 健介、永澤 秀子
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 二価鉄検出蛍光プローブの多色展開2017

    • Author(s)
      平山 祐、坪井 ひとみ、丹羽 正人、永澤 秀子
    • Organizer
      日本酸化ストレス学会東海支部第5回学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2016 Annual Research Report
  • [Presentation] A color series of fluorescent probes for detection of labile iron in living cells2016

    • Author(s)
      Tasuku Hirayama, Hitomi Tsuboi, Masato Niwa, Hideko Nagasawa
    • Organizer
      8th Asian Biological Inorganic Chemistry Conference
    • Place of Presentation
      Auckland, New Zealand
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a plasma membrane-anchoring Fe(II) probe based on N-oxide chemistry2016

    • Author(s)
      Masato Niwa, Tasuku Hirayama, Hideko Nagasawa
    • Organizer
      8th Asian Biological Inorganic Chemistry Conference
    • Place of Presentation
      Auckland, New Zealand
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体内での鉄(II)イオン検出を目指した19F-MRIプローブ分子の開発2016

    • Author(s)
      鈴木 萌恵、平山 祐、永澤 秀子
    • Organizer
      第14回がんとハイポキシア研究会
    • Place of Presentation
      岐阜
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞内鉄(II)イオン濃度の変動を検出できる蛍光プローブの開発2016

    • Author(s)
      丹羽 正人、平山 祐、奥田 健介、永澤 秀子
    • Organizer
      第14回がんとハイポキシア研究会
    • Place of Presentation
      岐阜
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞小器官選択的鉄(II)イオンプローブによるフェロトーシス誘導路の鉄動態解析2016

    • Author(s)
      平山 祐、三木 彩路、丹羽 正人、永澤 秀子
    • Organizer
      第14回がんとハイポキシア研究会
    • Place of Presentation
      岐阜
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] 多色化を目指した二価鉄蛍光プローブ群の開発2016

    • Author(s)
      平山 祐、丹羽 正人、坪井 ひとみ、永澤 秀子
    • Organizer
      第40回鉄バイオサイエンス学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞小器官選択的二価鉄蛍光プローブによる鉄依存的細胞死(Ferroptosisi)における鉄動態解明2016

    • Author(s)
      平山 祐、三木 彩路、丹羽 正人、永澤 秀子
    • Organizer
      第10回バイオ関連化学シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Molecular imaging of iron metabolism during ferroptosis with a novel mitochondria-targeting fluorescent probe2016

    • Author(s)
      Tasuku Hirayama, Masato Niwa, Satoki Kadota, Ayaji Miki, Kensuke Okuda, Hideko Nagasawa
    • Organizer
      World Molecular Imaging Conference 2016
    • Place of Presentation
      New York, USA
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生きた細胞の中で鉄を見る2016

    • Author(s)
      平山 祐
    • Organizer
      第29回生物無機化学夏季セミナー
    • Place of Presentation
      交野
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 酸化ストレス源としての鉄イオンを観ることで分かってきたこと2016

    • Author(s)
      平山 祐
    • Organizer
      フリーラジカルスクール2016
    • Place of Presentation
      館山
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 二価鉄イオン蛍光プローブの構造最適化とその応用2016

    • Author(s)
      丹羽 正人、平山 祐、永澤 秀子
    • Organizer
      第28回生体機能関連化学部会若手の会サマースクール
    • Place of Presentation
      蒲郡
    • Year and Date
      2016-07-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 二価鉄イオンに応答してキノンメチドを発生するタンパク質標識プローブの開発2016

    • Author(s)
      深谷 忠徳、平山 祐、永澤 秀子
    • Organizer
      創薬懇話会2016
    • Place of Presentation
      蓼科
    • Year and Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] がん細胞における二価鉄検出プローブによる鉄代謝イメージング2016

    • Author(s)
      三木 彩路、平山 祐、永澤 秀子
    • Organizer
      創薬懇話会2016
    • Place of Presentation
      蓼科
    • Year and Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞膜上に局在する鉄(II)イオン検出蛍光プローブの開発2016

    • Author(s)
      丹羽 正人、平山 祐、奥田 健介、永澤 秀子
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] ミトコンドリア局在型二価鉄蛍光プローブを使った鉄依存的細胞死の解析2016

    • Author(s)
      平山 祐、奥田 健介、永澤 秀子
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府
    • Year and Date
      2016-05-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Fe(II)-specific fluorescent probes to monitor cellular labile iron during oxidative stress-mediated biological events2016

    • Author(s)
      Tasuku Hirayama
    • Organizer
      第9回国際NO学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 二価鉄イオン蛍光プローブの構造最適化と細胞内二価鉄イオン変動の可視化2016

    • Author(s)
      丹羽正人、平山祐、奥田健介、永澤秀子
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 長波長鉄(II)イオン検出プローブの開発2016

    • Author(s)
      坪井ひとみ、平山祐、奥田健介、永澤秀子
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生体組織内での鉄(II)イオン検出を目指した19F-MRIプローブ分子の開発2016

    • Author(s)
      鈴木 萌恵、平山 祐、柳沢 大治郎、遠山 育夫、永澤 秀子
    • Organizer
      病院薬剤師会東海ブロック・薬学会東海支部合同学術集会
    • Place of Presentation
      岐阜
    • Related Report
      2016 Annual Research Report
  • [Presentation] 二価鉄イオン検出蛍光プローブを用いたferroptosisにおける鉄動態解析2016

    • Author(s)
      三木 彩路、平山 祐、永澤 秀子
    • Organizer
      病院薬剤師会東海ブロック・薬学会東海支部合同学術集会
    • Place of Presentation
      岐阜
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development and applications of fluorescent probes for selective and turn-on detection of Fe(II) ion2015

    • Author(s)
      Tasuku Hirayama, Masato Niwa, Kensuke Okuda, Hideko Nagasawa
    • Organizer
      Pacifichem2015
    • Place of Presentation
      ハワイ、米国
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds and its application2015

    • Author(s)
      Masato Niwa, Tasuku Hirayama, Kensuke Okuda, Hideko Nagasawa
    • Organizer
      Pacifichem2015
    • Place of Presentation
      ハワイ、米国
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 鉄(II)イオン蛍光プローブ群の多色展開2015

    • Author(s)
      平山祐、丹羽正人、坪井ひとみ、奥田健介、永澤秀子
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 細胞内小器官への局在性を持つ鉄(II)イオン蛍光プローブの開発2015

    • Author(s)
      平山祐、丹羽正人、門田聡基、奥田健介、永澤秀子
    • Organizer
      第39回日本鉄バイオサイエンス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 鉄(II)イオンの生細胞イメージングプローブの開発2015

    • Author(s)
      平山祐
    • Organizer
      RIKEN Center of Life Science Technologies 分子イメージングセミナー
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 細胞膜局在型二価鉄イオン蛍光プローブの開発とその応用2015

    • Author(s)
      丹羽正人、平山祐、奥田健介、永澤秀子
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 二価鉄イオン選択的蛍光プローブの開発と低酸素腫瘍細胞におけつ鉄イオンの挙動解明2014

    • Author(s)
      平山祐、形部智世、池下幸恵、奥田健介、永澤秀子
    • Organizer
      第12回がんとハイポキシア研究会
    • Place of Presentation
      佐賀
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 蛍光検出プローブを用いた二価鉄高感度検出への応用2014

    • Author(s)
      平山祐
    • Organizer
      中部三公立新技術説明会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 赤色蛍光団を用いた鉄(II)イオン検出プローブの開発2014

    • Author(s)
      坪井ひとみ、平山祐、奥田健介、永澤秀子
    • Organizer
      第8回バイオ関連化学シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞内における鉄(II)イオンを可視化する開口プローブ分子の開発2014

    • Author(s)
      平山祐、丹羽正人、門田聡基、奥田健介、永澤秀子
    • Organizer
      第38会日本鉄バイオサイエンス学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-06 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Imaging study of intracellular labile iron with new N-oxide-based fluorescent probes2014

    • Author(s)
      Hirayama T., Imamura T., Niwa M., Okuda K., Nagasawa H.
    • Organizer
      The 37th Naito Conference
    • Place of Presentation
      北海道
    • Year and Date
      2014-07-15 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 酸化ストレスにおける鉄(II)イオンを検出する蛍光プローブ分子の開発2014

    • Author(s)
      平山祐、丹羽正人、門田聡基、今村知代、奥田健介、原英彰、永澤秀子
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      東北大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] スピロ環開閉環平衡の制御に基づく新規鉄(II)イオン検出蛍光プローブの開発とその応用2014

    • Author(s)
      丹羽正人、平山祐、奥田健介、永澤秀子
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] ROS発生に関与する細胞内鉄イオンを可視化する蛍光分子の開発2013

    • Author(s)
      平山祐、丹羽正人、奥田健介、永澤秀子
    • Organizer
      第66回日本酸化ストレス学会学術集会
    • Place of Presentation
      ウィンクあいち
    • Related Report
      2013 Annual Research Report
  • [Presentation] N-オキシドの化学を利用した鉄(II)イオン蛍光プローブ分子の開発2013

    • Author(s)
      平山祐、丹羽正人、奥田健介、永澤秀子
    • Organizer
      日本ケミカルバイオロジー学会第8回年会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] ロドール骨格を有する新しい鉄(II)イオン検出蛍光プローブ分子の開発2013

    • Author(s)
      門田聡基、平山祐、奥田健介、永澤秀子
    • Organizer
      第59回日本薬学会東海支部総会・大会
    • Place of Presentation
      名城大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] スピロ環開閉環平衡の制御を基盤とした鉄(II)イオン検出蛍光プローブの開発2013

    • Author(s)
      丹羽正人、平山祐、奥田健介、永澤秀子
    • Organizer
      第7回バイオ関連化学シンポジウム
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 鉄(II)イオン検出剤及びそれを用いた検出方法2015

    • Inventor(s)
      永澤秀子、平山祐
    • Industrial Property Rights Holder
      岐阜市
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-01-16
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 鉄(II)イオン検出剤およびそれを用いた検出方法2014

    • Inventor(s)
      永澤秀子、平山祐
    • Industrial Property Rights Holder
      永澤秀子、平山祐
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-01-17
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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