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Glial influence on neuronal activity and behavior

Research Project

Project/Area Number 25702054
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Basic / Social brain science
Research InstitutionTohoku University

Principal Investigator

MATSUI Ko  東北大学, 医学(系)研究科(研究院), 准教授 (20435530)

Research Collaborator BEPPU Kaoru  
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2016: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords脳科学 / グリア細胞 / 光遺伝学 / オプトジェネティクス / グルタミン酸 / 細胞内イオン
Outline of Final Research Achievements

We have generated transgenic mice that express, in astrocytes of the glial cell population, fluorescent proteins that are sensitive to changes in intracellular pH or calcium. Compared to methods using synthetic dyes, these proteins are specifically expressed in astrocytes. Therefore, using acute brain slice preparations, local changes in the fine processes of the cells can be readily identified. In addition, small cranial window was created and optical fiber was inserted to observe the intracellular ionic changes in vivo. These methods along with the methods to optical control intracellular ionic changes using ChR2 and ArchT, we would be able to understand how astrocytes function affect neuronal activity and animal behavior.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (64 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (1 results) Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 4 results) Presentation (39 results) (of which Int'l Joint Research: 7 results,  Invited: 27 results) Book (2 results) Remarks (6 results)

  • [Int'l Joint Research] Heinrich-Heine-Universitaet(Germany)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 脳内情報処理を担うpHの役割:アストロサイト光操作法を用いた新展開2016

    • Author(s)
      松井 広
    • Journal Title

      日本薬理学雑誌

      Volume: 148 Pages: 64-68

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 神経科学を越えた光遺伝学の応用可能性2016

    • Author(s)
      松井 広
    • Journal Title

      日本レーザー医学誌

      Volume: 36 Pages: 473-477

    • NAID

      130005966839

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unveiling astrocytic control of cerebral blood flow with optogenetics2015

    • Author(s)
      Masamoto K, Unekawa M, Watanabe T, Toriumi H, Takuwa H, Kawaguchi H, Kanno I, Matsui K, Tanaka K F, Tomita Y, Suzuki N
    • Journal Title

      Scientific reports

      Volume: 5 Issue: 1 Pages: 11455-11455

    • DOI

      10.1038/srep11455

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Na,K-ATPaseα3 is a death target of alzheimer patient amyloid-β assembly.2015

    • Author(s)
      Ohnishi T, ..., Matsui K, ..., Hoshi M (計35名, 記載欄不足)
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 112 Issue: 32 Pages: 4465-4474

    • DOI

      10.1073/pnas.1421182112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] イオン濃度操作ツールとしてのオプトジェネティクス2015

    • Author(s)
      松井 広
    • Journal Title

      実験医学

      Volume: 33 Pages: 3074-3078

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Nanoscale distribution of presynaptic Ca2+ channels and its impact on vesicular release during development.2015

    • Author(s)
      Nakamura Y, Harada H, Kamasawa N, Matsui K, Rothman JS, Shigemoto R, Silver RA, DiGregorio DA, Takahashi T
    • Journal Title

      Neuron

      Volume: 85 Issue: 1 Pages: 145-158

    • DOI

      10.1016/j.neuron.2014.11.019

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo visualization of subtle, transient and local activity of astrocytes using an ultrasensitive Ca2+ indicator.2014

    • Author(s)
      Kanemaru K, Sekiya H, Xu M, Satoh K, Kitajima N, Yoshida K, Okubo Y, Sasaki T, Moritoh S, Hasuwa H, Mimura M, Horikawa K, Matsui K, Nagai T, Iino M, Tanaka KF
    • Journal Title

      Cell Rep

      Volume: 8(1),311 Issue: 1 Pages: 311-318

    • DOI

      10.1016/j.celrep.2014.05.056

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 光遺伝学のグリア細胞への応用と新知見2014

    • Author(s)
      別府 薫、松井 広
    • Journal Title

      日本臨牀

      Volume: 72 Pages: 2243-2249

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage2014

    • Author(s)
      Beppu K, Sasaki T, Tanaka K F, Yamanaka A, Fukazawa Y, Shigemoto R, Matsui K
    • Journal Title

      Neuron

      Volume: 81(2) Issue: 2 Pages: 314-320

    • DOI

      10.1016/j.neuron.2013.11.011

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] グリア機能の光制御から見えてきた脳科学研究の新しい地平2014

    • Author(s)
      松井 広
    • Journal Title

      細胞工学

      Volume: 33 Pages: 275-280

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Evaluation of glutamate concentration transient in the synaptic cleft of the rat calyx of Held2013

    • Author(s)
      Budisantoso T, Harada H, Kamasawa N, Fukazawa Y, Shigemoto R Matsui K
    • Journal Title

      Journal of Physiology

      Volume: 591 Issue: 1 Pages: 219-239

    • DOI

      10.1113/jphysiol.2012.241398

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative localization of Ca(v)2.1 (P/Q-type) voltage-dependent calcium channels in Purkinje cells: somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels2013

    • Author(s)
      Indriati DW, Kamasawa N, Matsui K, Meredith AL, Watanabe M, Shigemoto R
    • Journal Title

      Journal of Neuroscience

      Volume: 33 Issue: 8 Pages: 3668-3678

    • DOI

      10.1523/jneurosci.2921-12.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心に占めるグリア細胞の役割-光操作技術のもたらすパラダイム・シフト2013

    • Author(s)
      松井 広
    • Journal Title

      実験医学

      Volume: 31 Pages: 1712-1717

    • Related Report
      2013 Annual Research Report
  • [Journal Article] マウスの心の光操作-脳細胞活動と心の機能の因果関係を探る2013

    • Author(s)
      松井 広
    • Journal Title

      BRAIN and NERVE

      Volume: 65 Pages: 609-621

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 視床:単なる中継核ではない‐生理学的基礎2013

    • Author(s)
      松井 広
    • Journal Title

      Clinical Neuroscience

      Volume: 31 Pages: 24-26

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Kv4.2 potassium channels segregate to extrasynaptic domains in amygdala intercalated neurons and influence intrasynaptic NMDA receptor NR2B subunit expression2012

    • Author(s)
      Kaufmann WA, Matsui K, Jeromin A, Nerbonne J, Ferraguti F
    • Journal Title

      Brain Structure and Function

      Volume: - Issue: 5 Pages: 1-18

    • DOI

      10.1007/s00429-012-0450-1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] グリア機能を光で操り、こころの源を探る2017

    • Author(s)
      松井 広
    • Organizer
      新学術領域研究「グリアアセンブリ」第4回公開シンポジウム
    • Place of Presentation
      九州大学医学部百年講堂大ホール(福岡県)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Neural signal modulation by astrocyte activity2017

    • Author(s)
      Ko Matsui
    • Organizer
      第三回 Neuroscience Network in Kobe
    • Place of Presentation
      神戸大学大学院医学研究科神緑会館(兵庫県)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Optogenetic Control of Astrocytes and Mind2017

    • Author(s)
      Ko Matsui
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Ventura, CA, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Glial regulation of neuronal oscillations2017

    • Author(s)
      Ko Matsui
    • Organizer
      日本生理学会
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Glial regulation of neuronal activity and memory formation2017

    • Author(s)
      Soojin Kwon, Kaoru Beppu, Ko Matsui
    • Organizer
      日本生理学会
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グリア細胞による神経信号増幅機能の解明2016

    • Author(s)
      松井 広
    • Organizer
      日本薬学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] オプトジェネティクスを用いた脳病態研究の新展開2016

    • Author(s)
      松井 広
    • Organizer
      日本薬学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 神経信号のグリア増幅回路の光制御2016

    • Author(s)
      松井 広
    • Organizer
      公益財団法人千里ライフサイエンスセミナー
    • Place of Presentation
      千里ライフサイエンスセンタービル(豊中市)
    • Year and Date
      2016-02-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] アストロサイトによる神経信号の増幅機能と暴走過程の解明2016

    • Author(s)
      松井 広
    • Organizer
      Neurovascular Unit 研究会
    • Place of Presentation
      慶應義塾大学(新宿区)
    • Year and Date
      2016-01-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Possibility of pathology control via manipulation of astrocyte function2016

    • Author(s)
      Ko Matsui
    • Organizer
      日本神経科学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グリア光操作による脳虚血ダメージの軽減2016

    • Author(s)
      松井 広
    • Organizer
      生体機能と創薬シンポジウム
    • Place of Presentation
      東北大学川内北キャンパス(宮城県)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学による脳虚血神経障害発生メカニズムの解明2016

    • Author(s)
      松井 広
    • Organizer
      日本酸化ストレス学会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 精神は機能だ2016

    • Author(s)
      松井 広
    • Organizer
      伊香保BSの会
    • Place of Presentation
      群馬大学刀城会館(群馬県)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Functional editing of brain function via glial control2016

    • Author(s)
      Ko Matsui
    • Organizer
      JSPS Core-to-Core Program & OIST Joint Symposium
    • Place of Presentation
      沖縄科学技術大学院大学(沖縄県)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] グリア細胞による神経系発振ステート制御機構の解明2016

    • Author(s)
      松井 広
    • Organizer
      次世代脳プロジェクト冬のシンポジウム
    • Place of Presentation
      一橋講堂(東京都)
    • Related Report
      2016 Annual Research Report
  • [Presentation] グリア機能の光操作による脳病態機構の解明2015

    • Author(s)
      松井 広
    • Organizer
      筋委縮性側索硬化症(ALS)新規治療法開発をめざした病態解明
    • Place of Presentation
      都市センターホテル(千代田区)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Glia optogenetics2015

    • Author(s)
      Ko Matsui
    • Organizer
      Tohoku Forum for Creativity
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2015-07-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳虚血時におけるグリア活動暴走の光遺伝学的制御2015

    • Author(s)
      松井 広
    • Organizer
      日本薬理学会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2015-03-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポスト神経至上主義:グリア光操作による新たな展開2015

    • Author(s)
      松井 広
    • Organizer
      蔵王カンファレンス
    • Place of Presentation
      山形(蔵王四季のホテル)
    • Year and Date
      2015-01-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「神経」科学からの脱出:グリア光操作技術による統合脳科学への挑戦2014

    • Author(s)
      松井 広
    • Organizer
      立命館大学視覚科学統合研究センターセミナー
    • Place of Presentation
      滋賀(立命館大学)
    • Year and Date
      2014-12-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 光操作でグリア暴走を止める2014

    • Author(s)
      松井 広
    • Organizer
      日本レーザー医学会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2014-11-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Glial glutamate release and its role in neuronal information2014

    • Author(s)
      Ko Matsui
    • Organizer
      NIH-Japan-JSPS Symposium
    • Place of Presentation
      Bethesda, USA
    • Year and Date
      2014-10-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Glial control of behavior and brain damage2014

    • Author(s)
      Ko Matsui
    • Organizer
      Glial Heterogeneity Meeting
    • Place of Presentation
      Dusseldorf, Germany
    • Year and Date
      2014-10-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Active role of glia in neuronal circuit modulation and rampant glial signals in pathology2014

    • Author(s)
      Ko Matsui
    • Organizer
      CiNet Friday Lunch Seminar
    • Place of Presentation
      大阪(脳情報通信融合研究センター)
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 光で操作するグリア細胞活動2014

    • Author(s)
      松井 広
    • Organizer
      創薬薬理フォーラム
    • Place of Presentation
      東京(日本薬学会長井記念館)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] プラトンの洞窟からの脱出:オプトジェネティクスの光と影2014

    • Author(s)
      松井 広
    • Organizer
      グリアアセンブリ若手の会
    • Place of Presentation
      京都(仁和寺)
    • Year and Date
      2014-08-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] グリア光制御による脳神経細胞死防御2014

    • Author(s)
      松井 広
    • Organizer
      日本解剖学会総会
    • Place of Presentation
      自治医科大学キャンパス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Optogenic relief of ischemic brain damage2014

    • Author(s)
      Ko Matsui
    • Organizer
      光科学技術で拓く脳・精神科学平和探究研究会
    • Place of Presentation
      浜松
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 神経-グリアネットワークの機能と破綻2014

    • Author(s)
      松井 広
    • Organizer
      生理学研究所研究会「グローバルネットワークによる脳情報処理」
    • Place of Presentation
      岡崎
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Source and effect of glutamate liberate into the extracellular space2013

    • Author(s)
      Ko Matsui
    • Organizer
      KIST Seminar
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Proton triggered glial glutamate release underlies excitotoxicity upon ischemia2013

    • Author(s)
      Ko Matsui
    • Organizer
      JSPS Core-to-Core Program Symposium "Mechanisms of Synaptic Transmission"
    • Place of Presentation
      同志社大学田辺キャンパス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Optogenetic glial alkalization relieves ischemic brain damage2013

    • Author(s)
      K. BEPPU, T. SASAKI, K. F. TANAKA, A. YAMANAKA, Y. FUKAZAWA, R. SHIGEMOTO, K. MATSUI
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳と心の光操作2013

    • Author(s)
      松井 広
    • Organizer
      オプトジェネティクス講習会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Optogenetics for rescue2013

    • Author(s)
      Ko Matsui
    • Organizer
      光操作研究会
    • Place of Presentation
      慶應大学三田キャンパス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学応用の新たな展開2013

    • Author(s)
      松井 広
    • Organizer
      包括的脳科学研究推進支援ネットワーク・夏のワークショップ
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optogenetic control of glial cell activity2013

    • Author(s)
      Ko Matsui
    • Organizer
      European Meeting on Glial Cells in Health and Disease
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Optogenetic analysis of the role of glial cells in cerebellar circuit2013

    • Author(s)
      Ko Matsui
    • Organizer
      日本神経科学会大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 脳と行動の光操作2013

    • Author(s)
      松井 広
    • Organizer
      日本神経科学会大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Unveiling brain intercellular communication with optoelectrophysiology and simulations2013

    • Author(s)
      Ko Matsui
    • Organizer
      理化学研究所BSIセミナー招待講演
    • Place of Presentation
      和光
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Chapter 22. Casting Light on the Role of Glial Cells in Brain Function. in "Optogenetics: Light-sensing proteins and their applications."2015

    • Author(s)
      Ko Matsui
    • Total Pages
      409
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] オプトジェネティクス―光工学と遺伝学による行動抑制技術の最前線2013

    • Author(s)
      神取秀樹、松井広ほか執筆者45名
    • Total Pages
      288
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2013 Annual Research Report
  • [Remarks] 東北大学・松井広研究室

    • URL

      http://www.ims.med.tohoku.ac.jp/matsui/

    • Related Report
      2016 Annual Research Report
  • [Remarks] Young Glia

    • URL

      http://www.ims.med.tohoku.ac.jp/youngglia/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科・脳神経科学コアセンター・新医学領域創生分野

    • URL

      http://www.ims.med.tohoku.ac.jp/matsui/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科・脳神経科学コアセンター・新医学領域創生分野

    • URL

      http://www.ims.med.tohoku.ac.jp/matsui/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東北大学医学部プレスリリース「脳虚血時の細胞死誘導メカニズムへ光」

    • URL

      http://www.med.tohoku.ac.jp/news/2357.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東北大学プレスリリース「脳虚血時の細胞死誘導メカニズムへ光」

    • URL

      http://www.tohoku.ac.jp/japanese/2014/01/press20140122-03.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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