| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
We demonstrated the formation of lattice using DNA-functionalized nanoparticles (DNA-NPs) linked by DNA tetrahedral constructs. DNA tetrahedron has four symmetrical connecting bonds and plays a determining role in the inter-particle bonding; that allows for control of particles coordination. Using small angle x-ray scattering analysis, we observed and revealed the assembly of DNA-NPs into a diamond structure.
We also performed two-dimensional programmable assembly of nanoparticles on supported lipid bilayers (SLBs). Owing the high mobility of lipid molecules, two-dimensional diffusion of DNA-NPs on SLB was achieved. Using AFM imaging, we studied the morphology of the formation of DNA-NPs on SLB and its changes with annealing. We observed that DNA-NPs assemble into a densely-packed single-layered two-dimensional lattice through DNA hybridization.
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