Nanoparticle Assembly mediated by Designed DNA Nanostructures
| Project/Area Number |
25706009
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Nanobioscience
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| Research Institution | Nagoya University |
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Principal Investigator |
Tagawa Miho 名古屋大学, 未来材料・システム研究所, 准教授 (40512330)
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| Research Collaborator |
GANG Oleg Brookhaven National Lab.
Yager Kevin Brookhaven National Lab.
Starr Francis Wesleyan Univ.
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | DNA / ナノ粒子 / self-assembly / 自己集合 / 超格子構造 / コロイド結晶 / superlattice / ＤＮＡ / DNA self-assembly / Nanoparticle / Atomic Force Microscopy / Superlattice / 超構造 |
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| Outline of Final Research Achievements |
We demonstrated the formation of lattice using DNA-functionalized nanoparticles (DNA-NPs) linked by DNA tetrahedral constructs. DNA tetrahedron has four symmetrical connecting bonds and plays a determining role in the inter-particle bonding; that allows for control of particles coordination. Using small angle x-ray scattering analysis, we observed and revealed the assembly of DNA-NPs into a diamond structure.
We also performed two-dimensional programmable assembly of nanoparticles on supported lipid bilayers (SLBs). Owing the high mobility of lipid molecules, two-dimensional diffusion of DNA-NPs on SLB was achieved. Using AFM imaging, we studied the morphology of the formation of DNA-NPs on SLB and its changes with annealing. We observed that DNA-NPs assemble into a densely-packed single-layered two-dimensional lattice through DNA hybridization.
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Report
(5 results)
Research Products
(36 results)
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[Presentation] DNA-mediated Nanoparticle Crystallization2014
Author(s)
Miho Tagawa, Oleg Gang, Takumi Isogai, Sakiko Nakada, Eri Akada, Shunta Harada, Toru Ujihara
Organizer
The International Symposium on Material Architectonics for Sustainable Action(MASA)
Place of Presentation
NIMS, Tsukuba, Japan
Year and Date
2014-07-18
Related Report
Invited
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[Presentation] DNA-mediated Nanoparticle Assembly2013
Author(s)
Miho Tagawa, Takumi Isogai, Eri Akada, Shunta Harada, Toru Ujihara
Organizer
The 2nd International Workshop on Convergence in Condensed Matter and Nano Physics
Place of Presentation
Sungkyunkwan University, Korea
Related Report
Invited
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