Integration of Transport Functions into Arrayed Cell-Sized Proteoliposomes
Project/Area Number |
25706015
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Nano/Microsystems
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Research Institution | Kanagawa Academy of Science and Technology |
Principal Investigator |
OSAKI TOSHIHISA 公益財団法人神奈川科学技術アカデミー, 人工細胞膜システムグループ, 研究員 (50533650)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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Keywords | 生体機能模倣 / 生体分子(膜タンパク質) / 脂質 / マイクロ・ナノデバイス / 合成生物学 / 生体分子 (膜タンパク質) |
Outline of Final Research Achievements |
In former works, liposome, formed with a lipid bilayer, has been applied for the membrane of cell models; the membrane passively diffuses membrane-soluble molecules or water but unable to respond to the external stimuli. In this study, we therefore developed an array of functional proteoliposomes with a controlled cellular size. Our previously developed method, the precise micropatterning of lipids on a substrate, was further adjusted for the proteoliposome formation. The functions of membrane proteins were examined on the proteoliposome array obtained. As the next step, we plan to implement stimuli-responsive behavior into the proteoliposome array.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] 4.人工細胞膜作製とシングルイオンチャネル計測2015
Author(s)
神谷厚輝、大崎寿久、竹内昌治
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Journal Title
Electrochemistry
Volume: 83
Issue: 12
Pages: 1096-1100
DOI
NAID
ISSN
1344-3542, 2186-2451
Year and Date
2015-12-05
Related Report
Peer Reviewed
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[Book] 生体の科学2014
Author(s)
外岡大志、大崎寿久、竹内昌治
Total Pages
141
Publisher
医学書院
Related Report
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