| Budget Amount *help |
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Outline of Final Research Achievements |
In former works, liposome, formed with a lipid bilayer, has been applied for the membrane of cell models; the membrane passively diffuses membrane-soluble molecules or water but unable to respond to the external stimuli. In this study, we therefore developed an array of functional proteoliposomes with a controlled cellular size. Our previously developed method, the precise micropatterning of lipids on a substrate, was further adjusted for the proteoliposome formation. The functions of membrane proteins were examined on the proteoliposome array obtained. As the next step, we plan to implement stimuli-responsive behavior into the proteoliposome array.
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