| Budget Amount *help |
¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2013: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
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| Outline of Final Research Achievements |
The dynamic analysis of cellular migration using microscope systems has become a trend within research in biology, medicine and tissue engineering, as a means of studying the early stages of tissue formation etc. When observing a cell under the microscopic system, biochips made of glass materials are used to streamline the analysis. However, conventional biochip materials are not suited to the microscopic observation of the cell at the fluid boundary due to the refractive index mismatch between the medium and the biochip material. Therefore, the use of conventional biochips results in blurry microscopic images of cell migration near the fluid surface. For this reason, we have developed a method of fabricating 3D microfluidic chips made of the low refractive index fluoric polymer. A microfluidic chip made in this manner enabled us to more clearly observe the flagellum motion of the cell near the fluid surface, compared to the observations possible using conventional microfluidic chips.
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