Excited state dynamics of peptides by gas phase spectroscopy - photo protecting mechanism of protein
| Project/Area Number |
25708001
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Physical chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Keywords | 気相分光 / ペプチド / 励起状態ダイナミクス / レーザー脱離 / レーザー分光 |
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| Outline of Final Research Achievements |
Laser desorption supersonic jet laser spectroscopy was applied to several peptides including aromatic amino-acids to measure conformer-selected electronic and infrared spectra. By comparing them with theoretical calculations, structure of each conformer was determined, and the correlation between the structure and shape of the electronic spectrum (whether broadened or not) was discussed. In the case of the peptides including tyrosine, significant difference of excited state lifetime was not found among different conformers. On the other hand, in the tryptophan-inculded peptides, broadened electronic spectra were observed when the peptides form strong cyclic hydrogen bond between NH and CO and the tryptophan residue is included in that circle. From this result, it was suggested that such structures accelerate excited state relaxation process.
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Report
(4 results)
Research Products
(21 results)
