Develop bi-functional catalysts for innovative cross-coupling reaction
| Project/Area Number |
25708005
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
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| Keywords | カップリング反応 / 分子結合活性化 / 遷移金属触媒反応 / 天然物合成 / 分子活性化 / 触媒 / パラジウム / ニッケル / 合成化学 / 触媒化学 |
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| Outline of Final Research Achievements |
The C-H coupling method (C-H/C-X type coupling) requires dramatic advantage compared with a classical cross-coupling method (C-M/C-X type coupling) from substrate scope, reactivity and utility the point of view. Meanwhile, the applicant have also already been reported C-H/C-O coupling of azoles with phenol/enol derivatives and decarbonylative C-H coupling of azoles with phenyl esters /alkenyl esters, that are formally enable to activate both C-H bond and relatively stable C-Y bonds (Y = OR, CO2R) at the same time. We believe that this kind of multi-bonds (ethers, esters, nitriles, and amides) functionalization to create C-C bonds is entirely different from classical cross-coupling method and is to be next-generation cross-coupling method as well as one of the molecular technologies. Based on the motivation, we developed such a coupling methods and an enabled catalysts. We have achieved rapid syntheses of useful molecules and natural products.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] C-H Activation Generates Period-Shortening Moleculaes That Target Cryptochrome in the Mammalian Circadian Clock.2015
Author(s)
Oshima T, Yamanaka I, Kumar A, Yamaguchi J, Nishiwaki-Okawa T, Muto K, Kawamura R, Hirota T, Yagita K, Irie S, Kay SA, Yoshimura T, Itami K.
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Journal Title
Angew Chem Int Ed
Volume: 54
Issue: 24
Pages: 7193-7197
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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