| Budget Amount *help |
¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
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| Outline of Final Research Achievements |
The C-H coupling method (C-H/C-X type coupling) requires dramatic advantage compared with a classical cross-coupling method (C-M/C-X type coupling) from substrate scope, reactivity and utility the point of view. Meanwhile, the applicant have also already been reported C-H/C-O coupling of azoles with phenol/enol derivatives and decarbonylative C-H coupling of azoles with phenyl esters /alkenyl esters, that are formally enable to activate both C-H bond and relatively stable C-Y bonds (Y = OR, CO2R) at the same time. We believe that this kind of multi-bonds (ethers, esters, nitriles, and amides) functionalization to create C-C bonds is entirely different from classical cross-coupling method and is to be next-generation cross-coupling method as well as one of the molecular technologies. Based on the motivation, we developed such a coupling methods and an enabled catalysts. We have achieved rapid syntheses of useful molecules and natural products.
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