Studies on Alkylation Reactions of Arenes without Ortho-directing Groups
Project/Area Number |
25708006
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Partial Multi-year Fund |
Research Field |
Organic chemistry
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2016: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2015: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
|
Keywords | ベンゼン / アルケン / アルキル化 / 遷移金属 / ニッケル / 協働触媒 / ルイス酸 / アルミニウム / C-H 官能基化 / C-H官能基化 |
Outline of Final Research Achievements |
Alkylation reactions of arenes without ortho-directing groups have been investigated using alkenes as alkylating agents. First, we have found that nickel complexes bearing N-heterocyclic carbenes catalyze the reaction of benzene with 1-alkenes with unprecedentedly high linear selectivity to give linear alkylbenzenes. We have also shown that the nickel complexes in combination with aluminum-based Lewis acid cooperatively catalyze para- or meta-selective alkylation of benzenes bearing heteroatom-containing substituents such as aromatic carbonyl compounds, aromatic sulfonyl compounds, and anilides.
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Report
(6 results)
Research Products
(34 results)