Development of New Methods for Catalytic Organic Synthesis via Chain Walking
| Project/Area Number |
25708019
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Keio University |
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Principal Investigator |
Kochi Takuya 慶應義塾大学, 理工学部, 講師 (70396779)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
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| Keywords | パラジウム触媒 / 環化反応 / チェーンウォーキング / 有機合成 / 五員環形成反応 / 1,n-ジエン / ヒドロシリル化 / アルケン異性化反応 / βアセトキシ脱離 / アリール化 / 選択的異性化反応 / 末端アルケン / シリルエノールエーテル / ヒドロシリル化反応 / シクロペンタン誘導体 / 環化異性化反応 |
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| Outline of Final Research Achievements |
As a method to introduce a functional group at the reaction initiation site in the palladium-catalyzed chain-walking cycloisomerization of 1,n-dienes, we developed a cyclization/hydrosilylation of 1,n-dienes via chain-walking. In the presence of palladium catalysts, the reaction of various 1,n-dienes with hydrosilanes proceeded to give products formed by five-membered ring formation after the introduction of a silyl group, followed by chain walking. We also investigated on how to control the position of the alkene formed after the chain-walking process and found that the use of siloxy groups to form silyl enol ethers was effective for settling the position of the alkene after chain walking.
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Report
(5 results)
Research Products
(21 results)
