Design of supercritical impregnation process using molecular information for ocular drug delivery system

• Project/Area Number: 25709073
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Properties in chemical engineering process/Transfer operation/Unit operation
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Shimoyama Yusuke 東京工業大学, 理工学研究科, 准教授 (30403984)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2013: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: 超臨界流体 / 平衡物性 / 物質移動 / 薬物輸送システム / 超臨界二酸化炭素 / 含浸プロセス / 薬物放出 / 相平衡理論モデル / 超臨界含浸 / シリコンハイドロゲル / 眼科ドラッグデリバリーシステム

Outline of Final Research Achievements

Ophthalmic drug delivery system is fabricated by supercritical solution impregnation. The effect of impregnation temperature and pressure, addition of water on the drug release profile from the hydrogel is investigated. It is found that the loading amount of drug in the hydrogel from supercritical solution impregnation has the correlation with the solubility of drug in supercritical carbon dioxide. The theoretical model of the partition between supercritical carbon dioxide and water is constructed in order to design the process of the supercritical solution impregnation. The local composition model is applied for representing the hydrogen-bonding of drug and water molecules. The supercritical carbon dioxide impregnation is utilized for installing Vitami E into the silicone hydrogel. The Vitamin E is expected to reduce the drug diffusivity inside the hydrogel. The impregnation time of Vitamin E is reduced dramatically compared with conventional method by supercritical impregnaiton.

Research Products

• [Journal Article] Effect of temperature, pressure and depressurization rate on release profile of salicylic acid from contact lenses prepared by supercritical carbon dioxide impregnation (2015)
  • Author(s): Yusuta Yokozaki, Junichi Sakabe, Brendan Ng, Yusuke Shimoyama
  • Journal Title: Chemical Engineering Research and Design Volume: -
• [Journal Article] Enhanced impregnation of hydrogel contact lenses with salicylic acid by addition of water in supercritical carbon dioxide (2015)
  • Author(s): Yuta Yokozaki, Junichi Sakabe, Yusuke Shimoyama
  • Journal Title: Chemical Engineering Research and Design Volume: -
• [Presentation] Vitamin E loading into silicone hydrogel using supercritical carbon dioxide for diffusivity reduction on ophthalmic drug delivery system (2016)
  • Author(s): Yuta Yokozaki, Yusuke Shimoyama
  • Organizer: 15th European Meeting on Supercritical Fluids
  • Place of Presentation: Sanaa Building at Zollverein, Essen, Germary
  • Year and Date: 2016-05-08
  • Int'l Joint Research
• [Presentation] Modeling of phase equilibria for supercritical carbon dioxide system by hole-theory equation of state with local composition model (2016)
  • Author(s): Yusuke Shimoyama, Yuta Yokozaki
  • Organizer: 15th European Meeting on Supercritical Fluids
  • Place of Presentation: Sanaa Building at Zollverein, Essen, Germary
  • Year and Date: 2016-05-08
  • Int'l Joint Research
• [Presentation] ハイドロゲル中の薬物拡散抑制を目的とした超臨界CO2によるVitamin E含浸プロセス (2016)
  • Author(s): 横崎祐太，下山裕介
  • Organizer: 化学工学会第81年会
  • Place of Presentation: 関西大学千里山キャンパス
  • Year and Date: 2016-03-13
• [Presentation] 眼科薬物輸送システムにおける超臨界溶媒含浸法によるハイドロゲルのVitamin E修飾 (2015)
  • Author(s): 横崎祐太，下山裕介
  • Organizer: 第5回CSJ化学フェスタ
  • Place of Presentation: タワーホール船堀
  • Year and Date: 2015-10-13
• [Presentation] 局所組成を考慮した空孔理論による超臨界二酸化炭素＋水系の相平衡モデルの構築 (2014)
  • Author(s): 横崎祐太，下山裕介
  • Organizer: 化学工学会新潟大会
  • Place of Presentation: 新潟大学五十嵐キャンパス
  • Year and Date: 2014-11-22 – 2014-11-23
• [Presentation] Development of calculation model based on hole theory for phase equilibria of supercritical carbon dioxide system containing water (2014)
  • Author(s): Yuta Yokozaki, Yusuke Shimoyama
  • Organizer: 10th International Conference on Separation Science and Technology
  • Place of Presentation: Nara Prefectural New Public Hall, Nara, Japan
  • Year and Date: 2014-10-30 – 2014-11-01
• [Presentation] 超臨界二酸化炭素＋水系の相平衡計算における状態方程式中の外部自由度の影響 (2014)
  • Author(s): 横崎祐太，坂部淳一，内田博久，下山裕介
  • Organizer: 化学工学会第79年会
  • Place of Presentation: 岐阜大学柳戸キャンパス
• [Presentation] Supercritical solvent impregnation for drug-loaded lenses using carbon dioxide with water (2013)
  • Author(s): Yuta Yokozaki, Junichi Sakabe, Yusuke Shimoyama
  • Organizer: 2013 AIChE annual meeting
  • Place of Presentation: Hilton San Francisco Union Square
• [Presentation] 超臨界二酸化炭素を含浸溶媒とした眼科ドラッグデリバリーシステムの作製 (2013)
  • Author(s): 横崎祐太，坂部淳一，下山裕介
  • Organizer: 第3回CSJ化学フェスタ2013
  • Place of Presentation: タワーホール船堀＾
• [Presentation] Development of drug-loaded contact lenses using supercritical solvent impregnation method with carbon dioxide and water (2013)
  • Author(s): Yuta Yokozaki, Junichi Sakabe, Yusuke Shimoyama
  • Organizer: International Symposium for the 70th anniversary of the Tohoku Branch of the Chemical Society of Japan
  • Place of Presentation: 東北大学川内北キャンパス
• [Presentation] 超臨界含浸法による眼科ドラッグデリバリーシステム作製における水添加の影響 (2013)
  • Author(s): 横崎祐太，坂部淳一，下山裕介
  • Organizer: 化学工学会第45回秋季大会
  • Place of Presentation: 岡山大学津島（東）キャンパス
• [Presentation] 超臨界含浸法を用いた眼科ドラッグデリバリーシステム作製における水添加の影響 (2013)
  • Author(s): 横崎祐太，坂部淳一，下山裕介
  • Organizer: 化学工学会盛岡大会
  • Place of Presentation: 岩手大学人文科学部
• [Presentation] 超臨界含浸法を用いた眼科ドラッグデリバリーシステムの創製と薬物放出挙動の解明 (2013)
  • Author(s): 横崎祐太，坂部淳一，下山裕介
  • Organizer: 分離技術会年会2013
  • Place of Presentation: 日本大学生産工学部津田沼キャンパス