Design of supercritical impregnation process using molecular information for ocular drug delivery system
Project/Area Number |
25709073
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Partial Multi-year Fund |
Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
|
Research Institution | Tokyo Institute of Technology |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
|
Keywords | 超臨界流体 / 平衡物性 / 物質移動 / 薬物輸送システム / 超臨界二酸化炭素 / 含浸プロセス / 薬物放出 / 相平衡理論モデル / 超臨界含浸 / シリコンハイドロゲル / 眼科ドラッグデリバリーシステム |
Outline of Final Research Achievements |
Ophthalmic drug delivery system is fabricated by supercritical solution impregnation. The effect of impregnation temperature and pressure, addition of water on the drug release profile from the hydrogel is investigated. It is found that the loading amount of drug in the hydrogel from supercritical solution impregnation has the correlation with the solubility of drug in supercritical carbon dioxide. The theoretical model of the partition between supercritical carbon dioxide and water is constructed in order to design the process of the supercritical solution impregnation. The local composition model is applied for representing the hydrogen-bonding of drug and water molecules. The supercritical carbon dioxide impregnation is utilized for installing Vitami E into the silicone hydrogel. The Vitamin E is expected to reduce the drug diffusivity inside the hydrogel. The impregnation time of Vitamin E is reduced dramatically compared with conventional method by supercritical impregnaiton.
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Report
(4 results)
Research Products
(15 results)