Neural circuits regulating fear learning and anxiety disorders
| Project/Area Number |
25710003
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Johansen Joshua 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (80625351)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2014: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2013: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
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| Keywords | amygdala / prediction error / fear conditioning / teaching signal / Fear / periaqueductal gray / memory strength / fear / emotion / enxiety disorders / learning |
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| Outline of Final Research Achievements |
In our work on this grant we’ve identified a specific neural circuit which provides negative feedback to inhibit aversive shock processing when it is predicted by other sensory cues in the environment. Furthermore, we demonstrated function for this circuit in setting behavioral learning levels or asymptotes. Optogenetically inhibiting this feedback circuit disinhibited prediction error coding in lateral amygdala neurons which store fear memories resulting in exaggerated fear learning levels. Together this work reveals a distributed circuit mechanism for setting prediction error coding and fear memory strength. Prediction error coding is a ubiquitous neural coding mechanism in many learning circuits including those involved in reward and motor learning. This could represent a general feature of how prediction errors are encoded in the nervous system. Disruption of this feedback circuit could underlie anxiety disorders that are characterized by exaggerated aversive learning.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Evaluation of ambiguous associations in the amygdala by learning the structure of the environment.2016
Author(s)
Madarasz, T.J., Diaz-Mataix, L., Akhand, O., Ycu, E.A., LeDoux, J.E., Johansen, J.P.
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Journal Title
Nature Neuroscience
Volume: In press
Issue: 7
Pages: 965-972
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation2014
Author(s)
Johansen, J.P., Diaz-Mataix, L., Hamanaka, H. Ozawa, T., Ycu, E., Koivumaa, J., Kumar, A., Hou, M., Deisseroth, K., Boyden, E. & LeDoux, J.E.
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Journal Title
Proceedings of the National Academy of Sciences
Volume: 111(51)
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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