Sophisticate Design of Nano-Particular Type PET Probes for Qualitative Diagnosis and Theragnosis of Cancer
| Project/Area Number |
25710011
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Tumor diagnostics
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Mukai Hidefumi 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (60570885)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
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| Keywords | PETイメージング / がん / ナノ粒子 / セラグノーシス / 抗体 / ペプチド |
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| Outline of Final Research Achievements |
In vivo visualization of drug targets and disease-related molecules is essential for diagnosis and drug efficacy evaluation. To realize that, molecular probe development is a key. We developed novel approaches for the improvement of PET imaging contrast such as urokinase injection-triggered PET probe clearance enhancement system. These results could shorten the time required to obtain sufficient contrast and decrease patient radiation exposure.
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Report
(4 results)
Research Products
(10 results)
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[Presentation] Sturucture/biodistribution relationship of multi-arm PEGylated 64Cu-bombesin analogs as tumor imaging PET probes2014
Author(s)
Kazushi Matsumura, Hidefumi Mukai, Maki Zouda, Maiko Takahashi, Emi Hayashinaka, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida, Yasuhiro Wada, Yasuyoshi Watanabe
Organizer
2014 World Molecular Imaging Congress
Place of Presentation
Seoul, Korea, COEX Convention Center
Year and Date
2014-09-19
Related Report
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