Understanding metabolic systems for human gut microbiome
| Project/Area Number |
25710016
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Genome biology
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Yamada Takuji 東京工業大学, 生命理工学研究科, 講師 (10437262)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2015: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2013: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | バイオインフォマティクス / メタゲノミクス / ヒト腸内細菌 / データベース / 腸内細菌 / メタゲノム / 代謝ネットワーク |
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| Outline of Final Research Achievements |
Human gut harbors millions of microbiome, and their functional ability have wide diversity. Most of related works are based on KEGG database for their functional annotation, however, most of functional modules are not well known.
Here we developed the database for gut microbiome, called as “enteropathway”, allows researchers uncover functionality of gut microbiome more clearly. For example, we suggested few modules have high diversity across 1000 individuals, showing the diverse metabolic potential. In addition, these novel defined modules are under represented in Obesity patients comparing with healthy individuals.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Identification of Enzyme Genes Using Chemical Structure Alignments of Substrate-Product Pairs.2016
Author(s)
Moriya, Y., Yamada, T., Okuda, S., Nakagawa, Z., Kotera, M., Tokimatsu, T., Kanehisa, M. & Goto, S.
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Journal Title
Journal of Chemical Information and Modeling
Volume: 56
Issue: 3
Pages: 510-516
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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