| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2013: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Outline of Final Research Achievements |
We established the method of analyzing the entire cancer cell-stromal cell interaction (interactome) from the transcriptome sequence data of cancer xenograft tissues, by accurate separation of human and mouse sequence. Using this method, we analyzes the xenograft established from various type of cancer cells and clinical cancer tissues. We successfully confirmed that the interactome profile well reflects the actual histology of the cancer, and identified the candidate important interactions in a particular cancer subtype. For some of candidate molecules we could confirmed their tumor-specific and stroma-specific localization in actual clinical cancer tissues.
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