Sequence-based Cancer-stromal Interactome Analysis for Accessible Therapeutic Targets
Project/Area Number |
25710020
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Partial Multi-year Fund |
Research Field |
Medical genome science
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
SHUMPEI ISHIKAWA 東京医科歯科大学, 難治疾患研究所, 教授 (50418638)
|
Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Masato 東海大学, 医学科基盤診療学系, 教授 (00164335)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2013: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|
Keywords | ゲノム / がん / 治療標的 / 癌 / 病理学 |
Outline of Final Research Achievements |
We established the method of analyzing the entire cancer cell-stromal cell interaction (interactome) from the transcriptome sequence data of cancer xenograft tissues, by accurate separation of human and mouse sequence. Using this method, we analyzes the xenograft established from various type of cancer cells and clinical cancer tissues. We successfully confirmed that the interactome profile well reflects the actual histology of the cancer, and identified the candidate important interactions in a particular cancer subtype. For some of candidate molecules we could confirmed their tumor-specific and stroma-specific localization in actual clinical cancer tissues.
|
Report
(4 results)
Research Products
(13 results)
-
[Journal Article] The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma2015
Author(s)
Shin Saito, Kazue Morishima, Takashi Ui, Hiroko Hoshino, Daisuke Matsubara, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Yoshinori Hosoya, Naohiro Sato, Alan K Lefor, Yoshikazu Yasuda and Toshiro Niki
-
Journal Title
BMC cancer
Volume: 15
Issue: 1
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-