| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
|---|
| Outline of Final Research Achievements |
The project aimed at analyzing and understanding how extracellular signals of various spatio-temporal complexies are encoded at the level of signal transduction pathways. We employed Dictyostelium cell migration as a test case to quantitatively measure, based on live-cell confocal fluorescence imaging, the relationship between the spatio-temporal profiles of extracellular ligand versus several of the major signaling components that are important in determining their migratory behaviors. We found several key important properties such as fold-change dependency, adaptation, rectification in the input-output relations.
|
