| Budget Amount *help |
¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000)
Fiscal Year 2016: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
Selective types of autophagy, which target and degrade specific components in cells, have recently attracted much attention due to their direct relations to a number of human diseases. In this study, using a budding yeast as a model organism, we analyzed how selective autophagy is controlled, and revealed that multiple selective autophagy pathways are regulated by a uniform mechanism. In addition, we discovered new selective autophagy pathways that target the nucleus and the endoplasmic reticulum, and elucidated their molecular basis. Results obtained in this study will serve as basic information in developing therapeutic methods for related diseases.
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