| Budget Amount *help |
¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
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| Outline of Final Research Achievements |
Signal transduction pathways in eukaryotic cells are significant to understand cellular phenomena highly related to human life, e.g. cancer and cellular development and differentiation. In the field of computational biology, even though many algorithms have been developed, it is still difficult to simulate the signal transduction pathway at the single-molecule resolution, where only a few of molecules can affect the cellular fate. To overcome this difficulty, we have been developed a novel method named the enhanced Green's Function Reaction Dynamics (GFRD) method, which realizes fast and exact reaction-diffusion simulations in the single-particle level. In this study, we newly developed the parallelization algorithm of the GFRD method. This algorithm scales up simulations in time and space, and enables single-particle simulations of whole signal transduction pathways containing comprehensive structures such as cellular membrane, cell nucleus, and DNA.
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